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Coarse-Grained Models of the Proteins Backbone Conformational Dynamics

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Protein Conformational Dynamics

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 805))

Abstract

Coarse-grained models are more and more frequently used in the studies of the proteins structural and dynamic properties, since the reduced number of degrees of freedom allows to enhance the conformational space exploration. This chapter attemps to provide an overview of the various coarse-grained models that were applied to study the functional conformational changes of the polypeptides main chain around their native state. It will more specifically discuss the methods used to represent the protein backbone flexibility and to account for the physico-chemical interactions that stabilize the secondary structure elements.

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Authors and Affiliations

  1. BIOCIS – UMR CNRS 8076, Faculté de Pharmacie – Université Paris Sud, 5 rue Jean-Baptiste Clément, 92296, Châtenay-Malabry, France

    Tap Ha-Duong

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  1. Tap Ha-Duong
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Correspondence to Tap Ha-Duong .

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  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China

    Ke-li Han

  2. The Scripps Research Institute, La Jolla, California, USA

    Xin Zhang

  3. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People's Republic of China

    Ming-jun Yang

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Ha-Duong, T. (2014). Coarse-Grained Models of the Proteins Backbone Conformational Dynamics. In: Han, Kl., Zhang, X., Yang, Mj. (eds) Protein Conformational Dynamics. Advances in Experimental Medicine and Biology, vol 805. Springer, Cham. https://doi.org/10.1007/978-3-319-02970-2_7

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