Abstract
In order to characterize the mechanical properties of bioartificial microcapsules, we have designed an inverse analysis technique that combines microfluidic experiments with a multi-physical numerical model. The experiments consist of flowing a suspension of capsules in a channel with cross section similar to the particle size. The mechanical properties of the capsule membrane are deduced from the deformed shape by means of a fluid-structure interaction model of the problem. The model couples a boundary integral method to solve for the inner and outer fluid motion with a collocation method to solve for the membrane deformation. An optimization technique is used to find the parameters that provide the same deformation as measured experimentally and deduce an estimation of the membrane properties. The technique is applied on capsules with reticulated protein membranes.We show that it is possible to discriminate the influence of the physico-chemical conditions of fabrication.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barthès-Biesel, D.: Modeling the motion of capsules in flow. Current Opinion in Colloid and Interface Science 16, 3–12 (2011)
Lefebvre, Y., Leclerc, E., Barthès-Biesel, D., Walter, J., Edwards-Lévy, F.: Flow of artificial microcapsules in microfluidic channels: A method for determining the elastic properties of the membrane. Phys. Fluids 20, 123102 (2008)
Chu, T.X., Salsac, A.-V., Leclerc, E., Barthès-Biesel, D., Wurtz, H., Edwards-Lévy, F.: Comparison between measurements of elasticity and free amino group content of ovalbumin microcapsule membranes: discrimination of the cross-linking degree. Int. J. Coll. Interf. Sci. 355, 81–88 (2011)
Edwards-Lévy, F., Andry, M.C., Lévy, M.C.: Determination of free amino group content of serum albumin microcapsules using trinitrobenzenesulfonic acid: effect of variations in polycondensation pH. Int. J. Pharm. 96, 85–90 (1993)
Diaz, A., Barthès-Biesel, D.: Entrance of a Bioartificial Capsule in a Pore. CMES 3, 321–337 (2002)
Quéguiner, C., Barthès-Biesel, D.: Axisymmetric motion of the capsules through cylindrical channels. J. Fluid Mech. 348, 349–376 (1997)
Lefebvre, Y., Barthès-Biesel, D.: Motion of a capsule in a cylindrical tube: Effect of membrane pre-stress. J. Fluid Mech. 589, 157–181 (2007)
Barthès-Biesel, D., Diaz, A., Dhenin, E.: Effect of constitutive laws for two dimensional membranes on flow-induced capsule deformation. J. Fluid Mech. 460, 211–222 (2002)
Lac, E., Barthès-Biesel, D.: Deformation of a capsule in simple shear flow: Effect of membrane prestress. Phys. Fluids 17, 072105 (2005)
Sherwood, J.D., Risso, F., Collé-Paillot, F., Edwards-Lévy, F., Lévy, M.-C.: Rates of transport through a capsule membrane to attain Donnan equilibrium. Int. J. Coll. Interf. Sci. 263, 202–212 (2003)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this paper
Cite this paper
Chu, TX., Salsac, AV., Leclerc, E., Barthès-Biesel, D. (2014). Automatic Evaluation of the Elastic Modulus of a Capsule Membrane. In: Huynh, V., Denoeux, T., Tran, D., Le, A., Pham, S. (eds) Knowledge and Systems Engineering. Advances in Intelligent Systems and Computing, vol 245. Springer, Cham. https://doi.org/10.1007/978-3-319-02821-7_34
Download citation
DOI: https://doi.org/10.1007/978-3-319-02821-7_34
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-02820-0
Online ISBN: 978-3-319-02821-7
eBook Packages: EngineeringEngineering (R0)