Abstract
High rates of comorbidities with ADHD have been reported in both clinical samples and epidemiological studies. Authors such as Barkley (2002), indicated that comorbidity is generally high in ADHD in both children and adults. Several competing hypothesis are proposed to account for the patterns of comorbidity. Some suggested that maybe one disorder is an early manifestation of the other, development of one disorder increases the risk for the other, one disorder is a subtype of the other (conduct disorder and ADHD may be a subtype of ADHD), the comorbid disorders share common vulnerability factors or genetic and psychosocial factors, each disorder is an expression of phenotypic variability, or finally, each disorder is a separate entity.
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References
A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD (1999) Arch Gen Psychiatry 56(12):1073–1086
Angold A et al (1999) Comorbidity. J Child Psychol Psychiatry 49:57–88
Asherson P (2005) Clinical assessment and treatment of attention deficit hyperactivity disorder in adults. Expert Rev Neurother 5(4):525–539
Astill RG, Astill RG, Van der Heijden KB et al (2012) Sleep, cognition, and behavioral problems in school-age children. Psychol Bull 138:1109–1138
Barkley RA (2002) Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry 63:10–15
Barkley RA (1997) Attention deficit/hyperactivty. Disorder, self-regulation and time: toward a more comprehensive theory. J Dev Behav Paediatr 18:271–279
Barkley RA et al (2008) ADHD in adults: what the science says. Guilford Press, New York
Barkley RA et al (2004) Young adult follow up of hyperactive children: antisocial activities and drug use. J Child Psychol Psychiatry 45(2):195–211
Barkley RA, Biederman J (1997) Toward a broader definition of the age-of-onset criterion for attention-deficity hyperactity disorder. J Am Acad Child Adolesc Psychiatry 36(9):1204–1210
Barkley RA, DuPaul GJ, McMurray MB (1990) Comprehensive evaluation of attention deficit disorder with and without hyperactivity as defined by research criteria. J Consult Clin Psychol 58(6):775–789
Biederman J (2004) Impact of comorbidity in adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry 65(3):3–7
Biederman J et al (2007) Are girls with ADHD at risk of eating disorders? Results from a controlled, five year prospective study. J Dev Behav Pediatr 28(4):302–307
Biederman J et al (1996) Is childhood oppositional defiant disorder a precursor to adolescent conduct disorder? Findings from a four year follow up study of children with ADHD. J Am Acad Child Adolesc Psychiatry 35(9):1193–1204
Biederman J et al (1995) Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152(11):1652–1658
Birmaher B et al (2010) Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Offspring Study (BIOS). Am J Psychiatry 167(3):321–330
Bolton D, Luckie M, Steinberg D (1995) Long-term course of obsessive-compulsive disorder treated in adolescence. J Am Acad Child Adolesc Psychiatry 34(11):1441–1450
Brown TE (2009) ADHD comorbidities, 1st edn. American Psychiatric publishing, Washington, DC
Burns GL, Walsh JA (2002) The influence of ADHD on the development of ODD. J Abnorm Child Psychol 30(3):245–256
CADDRA is Candian ADHD Alliance network (2011). www.caddra.ca
Caron C, Ruiter M (1991) Comorbidity in child psychopathology: concepts, issues and research strategies. J Child Psychol Psychiatry 32(7):1063–1080
Capano L, Minden D, Chen SX, Schacher RJ, Ickowicz A (2008) Mathematical learning disorder in school-age children with attention-deficit hyperactivity disorder. Can J Psychiatry 53(6):392–399
Chervin RD, Archbold KH (2001) Hyperactivity and polysomnographic findings in children evaluated for sleep-disordered breathing. Sleep 24(3):313–320
Connor DF et al (2003) Correlates of comorbid psychopathology in children with ADHD. J Am Acad Child Adolesc Psychiatry 42(2):193–200
Connor DR et al (2002) Psychopharmacology and aggression. A meta-analysis of stimulant effects on over/covert aggression-related behaviors in ADHD. J Am Acad Child Adolesc Psychiatry 41(3):253–261
Consoli A et al (2007) Comorbidity with ADHD decreases response to pharmacotherapy in children and adolescents with acute mania: evidence from meta-analysis. Can J Psychiatry 52(5):3223–3328
Davids E, Gastpar M (2005) Attention deficit hyperactivity disorder and borderline personality disorder. Prog Neuropsychopharmacol Biol Psychiatry 29(6):865–877
Davis C (2010) Attention deficit/hyperactivity disorder: associations with overeating and obesity. Curr Psychiatry Rep 12(5):389–395
Davis SM et al (2010) Epilepsy in children with attention deficit/hyperactivity disorder. Pediatr Neurol 42(5):325–330
Ehlers S, Gillber C (1993) The epidemiology of Asperger syndrome. A total population study. J Child Psychol Psychiatry 34(8):1327–1350
Erhardt and Hinshaw SP (1994) Conduct disorder in childhood: conceptualization, diagnosis, comorbidity, and risk status for antisocial functioning in adulthood. Prog Exp Pers Psychopathol Res pp. 3–44
Faraone S, Wilens TE (2007) Effect of stimulant medications for attention-deficit/hyperactivity disorder on later substance use and the potential for stimulant misuse, abuse and diversion. J Clin Psychiatry 11:15–22
Fischer A et al (2007) The role of comorbid major depressive disorder in the clinical presentation of adult ADHD. J Psychiatr Res 41:991–996
Gadow KD et al (1999) Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Arch Gen Psychiatry 56(4):330–336
Gaffney GR et al (2002) Risperidone versus clonidine in the treatment of children and adolescents with Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry 41(3):330–336
Geller DA (2006) Obsessive-compulsive and spectrum disorders in children and adolescents. Psychiatr Clin N Am 29(2):353–370
Gonzales-Hydrich J et al (2010) Adaptive phase I study of OROS methylphenidate treatment of attention deficit hyperactivity disorder with epilepsy. Epilepsy Behav 18(3):229–237
Greenhill LL et al (2002) Practice parameter for the use of stimulant medications in the treatment of children, adolescents and adults. J Am Acad Child Adolesc Psychiatry 41(2):26S–49S
Guilleminault C et al (1982) Children and nocturnal snoring: evaluation of the effects of sleep related respiratory resistive load and daytime functioning. Eur J Pediatr 139(3):165–171
Hazell P (2010) Review of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder. Austr Psychiatry 18(6):556–559
Hechtman L (2009) Comorbidity and neuroimaging in attention-deficit hyperactivity disorder. Can J Psychiatry 54(10):649
Hofvander B, Ossowski D, Lundström S, Anckarsäter H (2009) Continuity of aggressive antisocial behavior from childhood to adulthood: the question of phenotype definition. Int J Law Psychiatry 32(4):224–234
Hughes CW et al (1999) The Texas Children’s Medication Algorithm Project: report of the Texas Consensus Conference Panel on Medication Treatment of Childhood Major Depressive Disorder. J Am Acad Child Adolesc Psychiatry 38(11):1442–1454
Keen D, Ward S (2004) Autistic spectrum disorder: a child population profile. Autism 8(1):39–48
Koneski JA, Casella EB (2010) Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to treatment. Arq Neuorpsiquiatr 68(1):107–114
Kooij ET et al (2004) Safety of methylphenidate in 45 adults with attention deficit/hyperactivity disorder. A randomized placebo-controlled double blind cross over trial. Psychol Med 34(6):973–982
Loeber R, Burke JD, Lahey BB (2002) What are adolescent antecedents to antisocial personality disorder? Crim Behav Ment Health 12(1):24–36
Luteijn EF et al (2000) How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD NOS and ADHD. Eur Child Adolesc Psychiatry 9(3):168–179
Mannuzza S et al (2004) Significance of childhood conduct problems to later development of conduct disorder among children with ADHD: a prospective follow up study. J Abnorm Child Psychol 32(5):565–573
Mayes S et al (2008) Non significance of sleep relative to IQ and neuropsychological scores. J Dev Behav Pediatr 29:206–212
McGillivray JA, Baker KL (2009) Effects of comorbid ADHD with learning disabilities on anxiety, depression, and aggression in adults. J Atten Disord 12(6):525–531
McKay KE, Halperin JM (2001) ADHD, aggression, and antisocial behavior across the lifespan. Interactions with neurochemical and cognitive function. Ann New York Acad Sci 931:84–96
Molina BS, Pelham WE Jr (2003) Childhood predictors of adolescent substance use in the longitudinal study of children with ADHD. J Abnorm Psychol 112(3):497–507
Murray MJ (2010) ADHD in the context of autism spectrum disorder. Curr Psychol Rep 12(5):382–388
MTA Cooperative Group (2004) National institute of Mental Health Multimodal Treatment Study of ADHD follow up: changes in effectiveness and growth after the end of treatment. Pediatrics 113(4):762–769
Parisi P et al (2010) Attention deficit hyperactivity disorder in children with epilepsy. Brain Dev 32(1):10–16
Philipsen A (2008) Differential diagnosis and comorbidity of attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) in adults. Eur Arch Psychiatry Clin Neurosci 258(3):192–193
Richardson AJ et al (2005) The Oxford-Durham study. Paediatrics 115:1360
Seindenberg M, Pulsipher DT, Hermann B (2009) Association of epilepsy and comorbid conditions. Future Neurol 4(5):663–668
Sobanski E et al (2007) Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci 257(7):371–377
Sowell ER et al (2003) Cortical abnormalities in children and adolescents with attention deficit hyperactivity disorder. Lancet 362(9397):1699–1707
Spencer TJ et al (2006) Efficacy and safety of mixed amphetamine salts extended release (AdderallXR) in the management of oppositional defiant disorder with or without comorbid attention deficit/hyperactivity disorder in school-aged children and adolescents: a 4-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled, forced-dose-escalation study. Clin Ther 28(3):402–418
Spencer T et al (1998) Disentangling the overlap between Tourette’s disorder and ADHD. J Child Psychol Psychiatry 39(7):1037–1044
Stein DJ, Lochner C (2006) Obsessive-compulsive spectrum disorders: a multidimensional approach. Psychiatr Clin N Am 29(2):343–351
Storch EA et al (2008) Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 47(5):583–592
Sukhodolsky DG et al (2003) Disruptive behavior in children with Tourette’s syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry 42(1):98–105
Turgay A (2005) Treatment of comorbidity in conduct disorder with attention deficit hyperactivity disorder (ADHD). Essent Psychopharmacol 6(5):277–290
Van der Heijden KB, Smits MG et al (2007) Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic insomnia. J Am Acad Child Adolesc Psychiatry 46:233–241
Vidair HB et al (2011) Screening parents during child evaluation. J Am Acad Child Adolesc Psychiatry 50(5):441–450
Wozniak J (2005) Recognizing and managing bipolar disorder in children. J Clin Psychiatry 66(1):18–23
Wentz E, Lacey JH et al (2005) Neuropsychiatric disorders in adult eating disorder patients. A pilot study. Eur Child Adolesc Psychiatry 14(8):431–437
Wilens TE (2007) The nature of the relationship between attention-deficit/hyperactivity disorder and substance use. J Clin Psychiatry 68(11):4–8
Wilens TE, Morrison NR (2011) The intersection of ADHD and substance abuse. Curr Opin Psychiatry 24(4):280–285, Review
Wilens TE et al (2008) The misuse and diversion of stimulants prescribed for ADHD. J Am Acad Child Adolesc Psychiatry 47:21–31
Wilens TE, Upadhyaya HP (2007) Impact of substance use disorder on ADHD and its treatment. J Clin Psychiatry 68(8):e20
Willoughby MT, Angold A et al (2008) Parent reported ADHD symptomatology and sleep problems in preschool children. J Am Acad Child Adolesc Psychiatry 47:186–194
Yoshida Y, Uchiyama T (2004) The clinical necessity for assessing Attention Deficit/Hyperactivity Disorder (AD/HD) symptoms in children with high-functioning Pervasive Developmental Disorder (PDD). Eur Child Adolesc Psychiatry 13(5):307–314
Young S, Thome J (2011) ADHD and offenders. World J Biol Psychiatry 12(1):124–128
Youssef NA, Ege M et al (2011) Is obstructive sleep apnea associated with ADHD? Ann Clin Psychiatry 23(3):213–224, Review
ADHD Guidelines Available on the Internet
American Psychological Association. http://www.apa.org/topics/adhd/index.aspx
Australian ADHD Draft Guidelines. http://www.nhmrc.gov.au/guidelines/publications/ch54
Canadian ADHD Guidelines. http://www.caddra.ca/cms4/
National Institute for Health and Clinical Excellence (NICE). http://publications.nice.org.uk/attention-deficit-hyperactivity-disorder-cg72
Scottish ADHD Guidelines. http://www.sign.ac.uk/guidelines/fulltext/112/index.html
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Sadek, J. (2014). ADHD Comorbidities. In: A Clinician’s Guide to ADHD. Springer, Cham. https://doi.org/10.1007/978-3-319-02359-5_8
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