Abstract
Definition: A soft tissue sarcoma characterized by tumor cells with diffuse pleomorphism in the absence of a specific line of differentiation. The old term malignant fibrous histiocytoma (MFH) is obsolete as immunohistochemistry demonstrated that the phenotype of the neoplastic cells is closely aligned with a fibroblast than a histiocyte. In the 2013 WHO classification, UPS is classified in the group of undifferentiated/unclassified sarcomas that are divided into pleomorphic (UPS), round cell, spindle cells, and epithelioid subsets. Together they account for up to 20 % of all soft tissue sarcomas.
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Gambarotti, M. (2014). Undifferentiated Pleomorphic Sarcoma (UPS). In: Picci, P., Manfrini, M., Fabbri, N., Gambarotti, M., Vanel, D. (eds) Atlas of Musculoskeletal Tumors and Tumorlike Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-01748-8_74
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DOI: https://doi.org/10.1007/978-3-319-01748-8_74
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