Abstract
Definition: Hemangiomas are benign tumors that closely resemble normal vessels. It is difficult to distinguish clearly among neoplasm, hamartoma, and malformations. Epithelioid hemangioma is a benign vascular tumor with well-formed but often immature vessels, lined by plump, epithelioid/histiocytoid endothelial cells. Epithelioid hemangioendothelioma is an angiocentric low-grade malignant vascular tumor, composed of epithelioid endothelial cells arranged in short cords and nests set in a distinctive myxohyaline stroma. Angiosarcoma is a malignant tumor composed of cells that variably recapitulate the morphologic features of normal endothelium.
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Arbiser JL, Bonner MY, Berrios RL (2009) Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med 9(8):929–934. Review
Errani C, Sung YS, Zhang L, Healey JH, Antonescu CR (2012) Monoclonality of multifocal epithelioid hemangioendothelioma of the liver by analysis of WWTR1-CAMTA1 breakpoints. Cancer Genet 205:12–17
Ganjoo K, Jacobs C (2010) Antiangiogenesis agents in the treatment of soft tissue sarcomas. Cancer 116(5):1177–1183. Review
Moukaddam H, Pollak J, Haims AH (2009) MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol 38(6):535–547. Review
Penel N, Marréaud S, Robin YM, Hohenberger P (2011) Angiosarcoma: state of the art and perspectives. Crit Rev Oncol Hematol 80:257–263
Rosai J (2010) Morphologic clues in vascular tumors. Int J Surg Pathol 18(3 Suppl):66S–70S. Review
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Gambarotti, M. (2014). Vascular Tumors: Hemangioma, Epithelioid Hemangioendothelioma, and Angiosarcoma. In: Picci, P., Manfrini, M., Fabbri, N., Gambarotti, M., Vanel, D. (eds) Atlas of Musculoskeletal Tumors and Tumorlike Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-01748-8_68
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DOI: https://doi.org/10.1007/978-3-319-01748-8_68
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