Abstract
Central and peripheral chondrosarcomas (CHS) present complex karyotypes and a genetic instability that results from early specific gene mutations followed by secondary genetic changes such as TP53 mutation and CDKN2 deletions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Bovée JV, Cleton-Jansen AM, Taminiau AH, Hogendoorn PC (2005) Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment. Lancet Oncol 6:599–607
Bovée JV, Hogendoorn PC, Wunder JS, Alman BA (2010) Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer 10:481–488
Grignani G, Palmerini E, Stacchiotti S, Boglione A, Ferraresi V, Frustaci S, Comandone A, Casali PG, Ferrari S, Aglietta M (2011) A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-alpha or -beta: an Italian Sarcoma Group study. Cancer 117:826–831
Reijnders CM, Waaijer CJ, Hamilton A, Buddingh EP, Dijkstra SP, Ham J, Bakker E, Szuhai K, Karperien M, Hogendoorn PC, Stringer SE, Bovée JV (2010) No haploinsufficiency but loss of heterozygosity for EXT in multiple osteochondromas. Am J Pathol 177:1946–1957
Ropero S, Setien F, Espada J, Fraga MF, Herranz M, Asp J, Benassi MS, Franchi A, Patino A, Ward LS, Bovee J, Cigudosa JC, Wim W, Esteller M (2004) Epigenetic loss of the familial tumor-suppressor gene exostosin-1(EXT-1) disrupts heparan sulfate synthesis in cancer cells. Hum Mol Genet 13:2753–2765
Schrage YM, Briaire-de Bruijn IH, de Miranda NFCC et al (2009) Kinome profiling of chondrosarcoma reveals Src-pathway activity and dasatinib as option for treatment. Cancer Res 69:6216–6222
Schrage YM, Machado I, Meijer D, Briaire-de Bruijn I, van den Akker BE, Taminiau AH, Kalinski T, Llombart-Bosch A, Bovée JV (2010) COX-2 expression in chondrosarcoma: a role for celecoxib treatment? Eur J Cancer 46:616–624
Stacchiotti S, Dagrada GP, Carlo Morosi C, Negri T, Romanini A, Silvana Pilotti S, Gronchi A, Casali PG (2012) Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib. Clin Sarcoma Res 2:22
Szuhai K, Jennes I, de Jong D, Bovée JV, Wiweger M, Wuyts W, Hogendoorn PC (2011) Tiling resolution array-CGH shows that somatic mosaic deletion of the EXT gene is causative in EXT gene mutation negative multiple osteochondromas patients. Hum Mutat 32:E2036–E2049
Szuhai K, Cleton-Jansen AM, Hogendoorn PC, Bovée JV (2012) Molecular pathology and its diagnostic use in bone tumors. Cancer Genet 205:193–204
Tiet TD, Hopyan S, Nadesan P, Gokgoz N, Poon R, Lin AC, Yan T, Andrulis IL, Alman BA, Wunder JS (2006) Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am J Pathol 168:321–330
van Oosterwijk JG, Herpers B, Meijer D, Briaire-de Bruijn IH, Cleton-Jansen AM, Gelderblom H, van de Water B, Bovée JV (2012) Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. Ann Oncol 23:1617–1626
van Oosterwijk JG, Meijer D, van Ruler MA, van den Akker BE, Oosting J, Krenács T, Picci P, Flanagan AM, Liegl-Atzwanger B, Leithner A, Athanasou N, Daugaard S, Hogendoorn PC, Bovée JV (2013) Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFβ as potential targets. Am J Pathol 182:1347–1356
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Benassi, M.S. (2014). Biology of Central and Peripheral Chondrosarcoma. In: Picci, P., Manfrini, M., Fabbri, N., Gambarotti, M., Vanel, D. (eds) Atlas of Musculoskeletal Tumors and Tumorlike Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-01748-8_32
Download citation
DOI: https://doi.org/10.1007/978-3-319-01748-8_32
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-01747-1
Online ISBN: 978-3-319-01748-8
eBook Packages: MedicineMedicine (R0)