Multiple Chondromas (Chondromatosis, Ollier’s Disease) Associated Condition: Maffucci’s Syndrome

Abstract

Multiple chondromas are infrequent, probably at least ten times less than solitary chondroma. The condition is not inherited and prevails in males. Their distribution and spectrum of presentation is variable. Only few chondromas are limited to the hands or one limb with minimal if any symptoms or, in other cases, diffusion is hemisomic, or extended to the entire body with hemisomic prevalence and overall features of diffuse chondrodysplasia, known as Ollier’s disease. The most affected bones are the small tubular bones of the hand and foot, but chondromas may present anywhere in the skeleton. Knobby swelling, bowing deformities, and lower limb length discrepancy (even >10 cm) are the dominant symptoms. Relationship between the polyostotic limited form and the fully expressed diffused chondrodysplasia (Ollier’s disease) remains unknown.