Abstract
Addictive substance use is most prevalent in people who are of reproductive-age. In a national prevalence survey performed among pregnant women aged 15–44 years, 10.8 % reported using alcohol, 17 % reported smoking during pregnancy, and 4.4 % reported abusing one or more illicit substances (Fig. 1) (SAMHSA 2011). Substance abuse for a pregnant woman is twice as dangerous as for others, because:
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References
Al-Saleh I, Shinwari N, Mashhour A, Mohamed Gel D, Rabah A (2011) Heavy metals (lead, cadmium and mercury) in maternal, cord blood and placenta of healthy women. Int J Hyg Environ Health 214:79–101
Anderson M, Elk R, Andres RL (1997) Social, ethical and practical aspects of perinatal substance use. J Subst Abuse Treat 14:481–486
Baranowski J, Pochopień G, Baranowska I (1998) Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography. J Chromatogr B 707:317–321
Borgerdinga M, Klusb H (2005) Analysis of complex mixtures: cigarette smoke. Exp Toxicol Pathol 57:43–73
Chen C, Cho SI, Damokosh AI, Chen D, Li G, Wang X, Xu X (2000) Prospective study of exposure to environmental tobacco smoke and dysmenorrhea. Environ Health Perspect 108:1019–1022
Daley M, Argeriou M, McCarty D (1998) Substance abuse treatment for pregnant women: a window of opportunity? Addict Behav 23:239–249
De Castro A, Concheiro M, Shakleya DM, Huestis MA (2009) Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry. J Anal Toxicol 33:243–252
Dejmek J, Solansky I, Podrazilová K, Srám RJ (2002) The exposure of nonsmoking and smoking mothers to environmental tobacco smoke during different gestational phases and fetal growth. Environ Health Perspect 110:601–610
Eskenazi B, Castorina R (1999) Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children. Environ Health Perspect 107:991–1000
Esteban M, Castaño A (2009) Non-invasive matrices in human biomonitoring: a review. Environ Int 35:438–449
Eyler FD, Behnke M, Wobie K, Garvan CW, Tebbett I (2005) Relative ability of biologic specimens and interviews to detect prenatal cocaine use. Neurotoxicol Teratol 27:677–687
Falcon M, Valero F, Pellegrini M, Rotolo MC, Scaravelli G, Joya J, Vall O, García Algar O, Luna A, Pichini S (2010) Exposure to psychoactive substances in women who request voluntary termination of pregnancy assessed by serum and hair testing. Forensic Sci Int 196:22–26
Finnegan LP (1994) Perinatal morbidity and mortality in substance using families: effects and intervention strategies. Bull Narcotics 46:19–43
Gilmour MI, Jaakkola MS, London SL, Nel AE, Rogers CA (2006) How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ Health Perspect 114:627–633
Gray T, Huestis M (2007) Bioanalytical procedures for monitoring in utero drug exposure. Anal Bioanal Chem 388:1455–1465
Gray TR, Eiden RD, Leonar KE, Connors GJ, Shisler S, Huestis MA (2010) Identifying prenatal cannabis exposure and effects of concurrent tobacco exposure on neonatal growth. Clin Chem 56:1442–1450
Gray TR, Shakleya DM, Huestis MA (2008) Quantification of nicotine, cotinine, trans-3′-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry. J Chromatogr B 863:107–114
Hakkola J, Pasanen M, Hukkanen J, Pelkonen O, Mäenpää J, Edwards RJ, Boobis AR, Raunio H (1996) Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol 51:403–411
Huestis MA, Choo RE (2002) Drug abuse’s smallest victims: in utero drug exposure. Forensic Sci Int 128:20–30
Huestis MA, Cone EJ (1998) Alternative testing matrices. In: Karch SB (ed) Drug abuse handbook, 2nd edn. CRC Press, Boca Raton, FL, pp 799–857
Jauniaux E, Burton GJ (2007) Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Hum Dev 83:699–706
Jones J (1974) Nutrition, drugs and their interrelations. PA Health 35:3
Joya X, Pujadas M, Falcón M, Civit E, Garcia-Algar O, Vall O, Pichini S, Luna A, De la Torre R (2010) Gas chromatography–mass spectrometry assay for the simultaneous quantification of drugs of abuse in human placenta at 12th week of gestation. Forensic Sci Int 196:38–42
Kissin WB, Svikis DS, Morgan GD, Haug NA (2001) Characterizing pregnant drug-dependent women in treatment and their children. J Subst Abuse Treat 21:27–34
Kulaga V, Shor S, Koren G (2010) Correlation between drugs of abuse and alcohol by hair analysis: parents at risk for having children with fetal alcohol spectrum disorder. Alcohol 44:615–621
Larkby C, Day N (1997) The effects of prenatal alcohol exposure. Alcohol Health Res World 21:192–198
Leino O, Kiviranta H, Karjalainen AK, Kronberg-Kippilä C, Sinkko H, Larsen EH, Virtanen S, Tuomisto JT (2011) Pollutant concentrations in placenta. Food Chem Toxicol 54:59–69
Loughhead AM, Fisher AD, Newport DJ, Ritchie JC, Owens MJ, DeVane CL, Stowe ZN (2006) Antidepressants in amniotic fluid: another route of fetal exposure. Am J Psychiatry 163:145–147
Lozano J, García-Algar O, Vall O, De la Torre R, Scaravelli G, Pichini S (2007) Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit 29:711–734
López P, Bermejo AM, Tabernero MJ, Fernández P, Alvarez I (2007) Determination of cocaine and heroin with their respective metabolites in meconium by gas chromatography–mass spectrometry. J Appl Toxicol 27:464–471
Marchei E, Escuder D, Pallas CR, Garcia-Algar O, Gómez A, Friguls B, Pellegrini M, Pichini S (2011) Simultaneous analysis of frequently used licit and illicit psychoactive drugs in breast milk by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal 55:309–316
Marx JA, Hockberger RS, Wall RM, Adams J (2002) Rosen’s emergency medicine: concepts and clinical practice, 5th edn. CV Mosby, St. Louis, pp 2396–2400
Miller WH, Hyatt MC (1992) Perinatal substance abuse. Am J Drug Alcohol Abuse 18:247–261
Myllynen P, Pasanen M, Pelkonen O (2005) Human placenta: a human organ for developmental toxicology research and biomonitoring. Placenta 26:361–371
Myren M, Mose T, Mathiesen L, Knudsen LE (2007) The human placenta—an alternative for studying fetal exposure. Toxicol Vitro 21:1332–1340
Narkowicz S, Polkowska Ż, Namieśnik J (2012) Analysis of markers of exposure to constituents of environmental tobacco smoke (ETS). Crit Rev Anal Chem 42:16–37
Niemann RA, Anderson DL (2008) Determination of iodide and thiocyanate in powdered milk and infant formulaby on-line enrichment ion chromatography with photodiode array detection. J Chrom A 1200:193–197
Nikolaou PD, Papoutsis II, Maravelias CP, Spiliopoulou CA, Pistos CM, Calokerinos AC, Atta-Politou J (2008) Development and validation of an EI-GC-MS method for the determination of methadone and its major metabolites (EDDP and EMDP) in human breast milk. J Anal Toxicol 32:478–484
Ostrea EM Jr, Hernandez JD, Bielawski DM, Kan JM, Leonardo GM, Abela MB, Church MW, Hannigan JH, Janisse JJ, Ager JW, Sokol RJ (2006) Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect? Alcohol Clin Exp Res 30:1152–1159
Otero C, Boles S, Young NK, Dennis K (2004) Methamphetamine: addiction, treatment, outcomes and implications. U.S. Department of Health and Human Services, SAMHSA, Rockville, MD
Pellegrini M, Marchei E, Rossi S, Vagnarelli F, Durgbanshi A, Garcĺa-Algar Ó, Vall O, Pichini S (2007) Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk. Rapid Commun Mass Spectrom 21:2693–2703
Phibbs CS, Bateman DA, Schwartz RM (1991) The neonatal costs of maternal cocaine use. J Am Med Assoc 266:1521–1526
Pichini S, Altieri I, Pellegrini M, Pacifici R, Zuccaro P (1997) The analysis of nicotine in infants' hair for measuring exposure to environmental tobacco smoke. Forensic Sci Int 84:253–258
Polkowska Ż, Kozłowska K, Witkowska E, Namieśnik J (2004) Materiały biologiczne pochodzenia ludzkiego jako źródło informacji o narażeniu człowieka na środowiskowe czynniki chemiczne. In: Collective work. Bioanalityka w ocenie zanieczyszczeń środowiska. CEEAM, Gdansk, pp 75–107
Quertemont E, Didone V (2006) Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol. Alcohol Res Helth 29:258–266
Rogers JM (2009) Tobacco and pregnancy. Reprod Toxicol 28:152–160
SAMHSA (2011) Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. NSDUH Series H-41, HHS Publication No. (SMA) 11–4658. Rockville, MD: Substance Abuse and Mental Health Services Administration. http://www.samhsa.gov/data/NSDUH/2k10NSDUH/2k10Results.htm. Accessed 7 June 2012
Scharnberg K (2003) Prosecutors targeting pregnant drug users; some fear women will shun treatment. Chi Trib Nov 23:C1
Schütz H, Paine A, Erdmann F, Weiler G, Verhoff MA (2006) Immunoassays for drug screening in urine. Forensic Sci Med Pathol 2:75–83
Shakleya DM, Dams R, Choo RE, Jones H, Huestis MA (2010) Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and metabolites in opiate-dependent pregnant women in methadone-maintenance treatment. J Anal Toxicol 34:17–25
Van der Aa EM, Peereboom-Stegeman JH, Noordhoek J, Gribnau FW, Russel FG (1998) Mechanisms of drug transfer across the human placenta. Pharm World Sci 20:139–148
Vinner E, Vignau J, Thibault D, Codaccioni X, Brassart C, Humbert L, Lhermitte M (2003) Neonatal hair analysis contribution to establishing a gestational drug exposure profile and predicting a withdrawal syndrome. Ther Drug Monit 25:421–432
Vogel A (1997) Neurodevelopment: cocaine wreaks subtle damage on developing brains. Science 278:38–39
Zuckerman B, Frank DA, Hingson R, Amaro H, Levenson SM (1989) Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med 320:762–768
Acknowledgments
Justyna Płotka and Sylwia Narkowicz express their gratitude for financial support received from the Human Capital Programme (POKL.04.01.01-00-368/09).
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Płotka, J., Narkowicz, S., Polkowska, Ż., Biziuk, M., Namieśnik, J. (2014). Effects of Addictive Substances During Pregnancy and Infancy and Their Analysis in Biological Materials. In: Whitacre, D. (eds) Reviews of Environmental Contamination and Toxicology, Volume 227. Reviews of Environmental Contamination and Toxicology, vol 227. Springer, Cham. https://doi.org/10.1007/978-3-319-01327-5_2
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