Skip to main content
SpringerLink
Log in
Book cover

Calcium Signaling In Airway Smooth Muscle Cells pp 147–175Cite as

Temporal Aspects of Ca2+ Signaling in Airway Myocytes

  • Chapter
  • First Online:

  • 1004 Accesses

Abstract

This chapter discusses how variation in intracytoplasmic Ca2+ concentration ([Ca2+]i) over time can be considered as a signal for the contractile machinery. It presents an overview of the literature that describes the Ca2+ response pattern to different contractile or relaxant agonists in several types of airway smooth muscle cells (ASMCs) depending on the species and location in the airway tree and recording methods, insisting on the temporal aspects of this response. Since the dynamics of the Ca2+ signal depends on the dynamics of the mechanisms responsible for this signal, the chapter presents an overview of the main mechanisms responsible for Ca2+ homeodynamics in ASMCs. By analyzing some examples, it shows how the kinetics of these mechanisms determine the pattern of the Ca2+ signal. The consequence of cell-to-cell variations in the Ca2+ signal is also discussed, with special attention to oscillatory versus nonoscillatory responses. The last part of the chapter presents the relationship between the parameter of the Ca2+ signal and the pattern of the contractile response. The mechanisms of the contractile apparatus itself will not be detailed, this question being beyond the scope of the chapter, but the temporal relationship between the Ca2+ signal and the subsequent contraction is analyzed.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Ikeda, M., K. Kurokawa, and Y. Maruyama, Cyclic nucleotide-dependent regulation of agonist-induced calcium increases in mouse megakaryocytes. J Physiol, 1992. 447: p. 711–28.

    PubMed  CAS  Google Scholar 

  2. Roux, E. and M. Marhl, Role of sarcoplasmic reticulum and mitochondria in ca(2+) removal in airway myocytes. Biophys J, 2004. 86(4): p. 2583–95.

    Article  PubMed  CAS  Google Scholar 

  3. Csete, M. and J. Doyle, Bow ties, metabolism and disease. Trends in Biotechnology, 2004. 22(9): p. 446–450.

    Article  PubMed  CAS  Google Scholar 

  4. Ma, H.W. and A.P. Zeng, The connectivity structure, giant strong component and centrality of metabolic networks. Bioinformatics, 2003. 19(11): p. 1423–1430.

    Article  PubMed  CAS  Google Scholar 

  5. Marhl, M., M. Perc, and S. Schuster, Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations. FEBS Lett., 2005. 579(25): p. 5461–5465.

    Article  PubMed  CAS  Google Scholar 

  6. Schuster, S., B. Knoke, and M. Marhl, Differential regulation of proteins by bursting calcium oscillations - a theoretical study. Biosystems, 2005. 81(1): p. 49–63.

    Article  PubMed  CAS  Google Scholar 

  7. Bai, Y., M. Edelmann, and M.J. Sanderson, The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol, 2009. 297(2): p. L347–61.

    Article  PubMed  CAS  Google Scholar 

  8. Hyvelin, J.M., et al., Cellular mechanisms of acrolein-induced alteration in calcium signaling in airway smooth muscle. Toxicol Appl Pharmacol, 2000. 164(2): p. 176–83.

    Article  PubMed  CAS  Google Scholar 

  9. Roux, E., et al., [Ca 2+ ] i oscillations induced by muscarinic stimulation in airway smooth muscle cells: receptor subtypes and correlation with the mechanical activity. Br J Pharmacol, 1997. 120: p. 1294–1301.

    Article  PubMed  CAS  Google Scholar 

  10. Roux, E., et al., Muscarinic stimulation of airway smooth muscle cells. Gen Pharmacol, 1998. 31(3): p. 349–56.

    Article  PubMed  CAS  Google Scholar 

  11. Liu, X. and J.M. Farley, Frequency modulation of acetylcholine-induced Ca(++)-dependent Cl- current oscillations are mediated by 1, 4, 5-trisphosphate in tracheal myocytes. J Pharmacol Exp Ther, 1996. 277: p. 796–804.

    PubMed  CAS  Google Scholar 

  12. Kannan, M.S., et al., Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol, 1997. 272(4 Pt 1): p. L659–64.

    PubMed  CAS  Google Scholar 

  13. Prakash, Y.S., M.S. Kannan, and G.C. Sieck, Regulation of intracellular calcium oscillations in porcine tracheal smooth muscle cells. Am J Physiol, 1997. 272(3 Pt 1): p. C966–75.

    PubMed  CAS  Google Scholar 

  14. Prakash, Y.S., et al., Role of cyclic ADP-ribose in the regulation of [Ca2+]i in porcine tracheal smooth muscle. Am J Physiol, 1998. 274(6 Pt 1): p. C1653–60.

    PubMed  CAS  Google Scholar 

  15. Marthan, R., et al., Calcium channel currents in isolated smooth muscle cells from human bronchus. J Appl Physiol, 1989. 66: p. 1706–1714.

    PubMed  CAS  Google Scholar 

  16. Kotlikoff, L., Calcium currents in isolated canine airway smooth muscle cells. Am J Physiol, 1988. 254: p. C793–C801.

    PubMed  CAS  Google Scholar 

  17. Rodger, I.W., Voltage-dependent and receptor-operated calcium channels, in Airways smooth muscle: biochemical control of contraction and relaxation, D. Raeburn and M.A. Giembycz, Editors. 1994, Birkhäuser Verlag: Basel. p. 155–168.

    Google Scholar 

  18. McFadzean, I. and A. Gibson, The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br J Pharmacol, 2002. 135(1): p. 1–13.

    Article  PubMed  CAS  Google Scholar 

  19. Mounkaila, B., R. Marthan, and E. Roux, Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation. Respir Res, 2005. 6(1): p. 143.

    Article  PubMed  Google Scholar 

  20. Sanders, K.M., Invited review: mechanisms of calcium handling in smooth muscles. J Appl Physiol, 2001. 91(3): p. 1438–49.

    PubMed  CAS  Google Scholar 

  21. Helli, P.B., E. Pertens, and L.J. Janssen, Cyclopiazonic acid activates a Ca2+−permeable, nonselective cation conductance in porcine and bovine tracheal smooth muscle. J Appl Physiol, 2005. 99(5): p. 1759–68.

    Article  PubMed  CAS  Google Scholar 

  22. Ay, B., et al., Store-operated Ca2+ entry in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 2004. 286(5): p. L909–17.

    Article  PubMed  CAS  Google Scholar 

  23. Marthan, R., Store-operated calcium entry and intracellular calcium release channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol, 2004. 286(5): p. L907–8.

    Article  PubMed  CAS  Google Scholar 

  24. Janssen, L.J., D.K. Walters, and J. Wattie, Regulation of [Ca2+]i in canine airway smooth muscle by Ca(2+)-ATPase and Na+/Ca2+ exchange mechanisms. Am J Physiol, 1997. 273(2 Pt 1): p. L322–30.

    PubMed  CAS  Google Scholar 

  25. Flores-Soto, E., et al., In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors. Pflugers Arch, 2011. 461(2): p. 261–75.

    Article  PubMed  CAS  Google Scholar 

  26. Liu, B., et al., Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation. Respir Res, 2010. 11: p. 168.

    Article  PubMed  CAS  Google Scholar 

  27. Iwamoto, T. and M. Shigekawa, Differential inhibition of Na+/Ca2+ exchanger isoforms by divalent cations and isothiourea derivative. Am J Physiol, 1998. 275(2 Pt 1): p. C423–30.

    PubMed  CAS  Google Scholar 

  28. Pitt, A. and A.J. Knox, Molecular characterization of the human airway smooth muscle Na+/Ca2+ exchanger. Am J Respir Cell Mol Biol, 1996. 15(6): p. 726–30.

    Article  PubMed  CAS  Google Scholar 

  29. Sims, S.M., Y. Jiao, and Z.G. Zheng, Intracellular calcium stores in isolated tracheal smooth muscle cells. Am J Physiol, 1996. 271(2 Pt 1): p. L300–9.

    PubMed  CAS  Google Scholar 

  30. Roux, E., J.-P. Mazat, and M. Marhl, Role of mitochondria in calcium homeostasis and contraction of smooth muscle cells, in Mitochondria: Structure, Functions and Dysfunctions, O.L. Svensson, Editor. 2009, Nova Publisher: Hauppauge NY.

    Google Scholar 

  31. Roux, E., et al., Modelling of calcium handling in airway myocytes. Prog Biophys Mol Biol, 2006. 90(1–3): p. 64–87.

    Article  PubMed  CAS  Google Scholar 

  32. Marhl, M., et al., Modelling oscillations of calcium and endoplasmic reticulum transmembrane potential; role of the signalling and buffering proteins and of the size of the Ca2+ sequestering ER subcompartments. Bioelectrochem Bioenerg, 1998. 46: p. 79–90.

    Article  CAS  Google Scholar 

  33. Bai, Y. and M.J. Sanderson, The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice. Am J Physiol Lung Cell Mol Physiol, 2009. 296(6): p. L947–58.

    Article  PubMed  CAS  Google Scholar 

  34. Mbikou, P., et al., Theoretical and experimental investigation of calcium-contraction coupling in airway smooth muscle. Cell Biochem Biophys, 2006. 46(3): p. 233–52.

    Article  PubMed  CAS  Google Scholar 

  35. Roux, E., M. Duvert, and R. Marthan, Combined effect of chronic hypoxia and in vitro exposure to gas pollutants on airway reactivity. Am J Physiol Lung Cell Mol Physiol, 2002. 283(3): p. L628–35.

    PubMed  CAS  Google Scholar 

  36. Roux, E., et al., Calcium signaling in airway smooth muscle cells is altered by in vitro exposure to the aldehyde acrolein. Am J Respir Cell Mol Biol, 1998. 19(3): p. 437–44.

    Article  PubMed  CAS  Google Scholar 

  37. Perez-Zoghbi, J.F., Y. Bai, and M.J. Sanderson, Nitric oxide induces airway smooth muscle cell relaxation by decreasing the frequency of agonist-induced Ca2+ oscillations. J Gen Physiol, 2010. 135(3): p. 247–59.

    Article  PubMed  CAS  Google Scholar 

  38. Jiang, H., et al., Phosphoinositide 3-kinase gamma regulates airway smooth muscle contraction by modulating calcium oscillations. J Pharmacol Exp Ther, 2010. 334(3): p. 703–9.

    Article  PubMed  CAS  Google Scholar 

  39. Delmotte, P. and M.J. Sanderson, Effects of formoterol on contraction and Ca2+ signaling of mouse airway smooth muscle cells. Am J Respir Cell Mol Biol, 2010. 42(3): p. 373–81.

    Article  PubMed  CAS  Google Scholar 

  40. Bai, Y., M. Zhang, and M.J. Sanderson, Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol, 2007. 36(1): p. 122–30.

    Article  PubMed  CAS  Google Scholar 

  41. Bergner, A., et al., Ca2+−signaling in airway smooth muscle cells is altered in T-bet knock-out mice. Respir Res, 2006. 7: p. 33.

    Article  PubMed  Google Scholar 

  42. Perez, J.F. and M.J. Sanderson, The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol, 2005. 125(6): p. 535–53.

    Article  PubMed  CAS  Google Scholar 

  43. Bergner, A. and M.J. Sanderson, Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices. J Gen Physiol, 2002. 119(2): p. 187–98.

    Article  PubMed  CAS  Google Scholar 

  44. Campos-Bedolla, P., et al., Airway smooth muscle relaxation induced by 5-HT(2A) receptors: role of Na(+)/K(+)-ATPase pump and Ca(2+)-activated K(+) channels. Life Sci, 2008. 83(11–12): p. 438–46.

    Article  PubMed  CAS  Google Scholar 

  45. Oguma, T., et al., Roles of P2X receptors and Ca2+ sensitization in extracellular adenosine triphosphate-induced hyperresponsiveness in airway smooth muscle. Clin Exp Allergy, 2007. 37(6): p. 893–900.

    Article  PubMed  CAS  Google Scholar 

  46. Janssen, L.J., T. Tazzeo, and J. Zuo, Enhanced myosin phosphatase and Ca(2+)-uptake mediate adrenergic relaxation of airway smooth muscle. Am J Respir Cell Mol Biol, 2004. 30(4): p. 548–54.

    Article  PubMed  CAS  Google Scholar 

  47. Prakash, Y.S., et al., Spatial and temporal aspects of ACh-induced [Ca2+]i oscillations in porcine tracheal smooth muscle. Cell Calcium, 2000. 27(3): p. 153–62.

    Article  PubMed  CAS  Google Scholar 

  48. Fleischmann, B.K., Y.X. Wang, and M.I. Kotlikoff, Muscarinic activation and calcium permeation of nonselective cation currents in airway myocytes. Am J Physiol, 1997. 272(1 Pt 1): p. C341-9.

    PubMed  CAS  Google Scholar 

  49. Wang, Y.X., B.K. Fleischmann, and M.I. Kotlikoff, M2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/G(o) requirements. Am J Physiol, 1997. 273(2 Pt 1): p. C500–8.

    PubMed  CAS  Google Scholar 

  50. Kajita, J. and H. Yamaguchi, Calcium mobilization by muscarinic cholinergic stimulation in bovine single airway smooth muscle. Am J Physiol, 1993. 264: p. L496–L503.

    PubMed  CAS  Google Scholar 

  51. Schaafsma, D., et al., Differential Rho-kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction. Br J Pharmacol, 2006. 147(7): p. 737–43.

    Article  PubMed  CAS  Google Scholar 

  52. Janssen, L.J. and S.M. Sims, Ca(2+)-dependent Cl- current in canine tracheal smooth muscle cells. Am J Physiol, 1995. 269(1 Pt 1): p. C163–9.

    PubMed  CAS  Google Scholar 

  53. McCann, J.D. and M.J. Welsh, Calcium-activated potassium channels in canine airway smooth muscle. J Physiol, 1986. 372: p. 113–27.

    PubMed  CAS  Google Scholar 

  54. Wade, G.R. and S.M. Sims, Muscarinic stimulation of tracheal smooth muscle cells activates large-conductance Ca(2+)-dependent K+ channel. Am J Physiol, 1993. 265(3 Pt 1): p. C658–65.

    PubMed  CAS  Google Scholar 

  55. Amrani, Y., et al., Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform. Br J Pharmacol, 1995. 115(7): p. 1204–10.

    Article  PubMed  CAS  Google Scholar 

  56. Govindaraju, V., et al., The effects of extracellular purines and pyrimidines on human airway smooth muscle cells. J Pharmacol Exp Ther, 2005. 315(2): p. 941–8.

    Article  PubMed  CAS  Google Scholar 

  57. Hyvelin, J.M., et al., Human isolated bronchial smooth muscle contains functional ryanodine/caffeine-sensitive Ca-release channels. Am J Respir Crit Care Med, 2000. 162(2 Pt 1): p. 687–94.

    Article  PubMed  CAS  Google Scholar 

  58. Ressmeyer, A.R., et al., Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity. Am J Respir Cell Mol Biol, 2010. 43(2): p. 179–91.

    Article  PubMed  CAS  Google Scholar 

  59. Liu, X. and J.M. Farley, Acetylcholine-induced Ca++−dependent chloride current oscillations are mediated by inositol 1,4,5-trisphosphate in tracheal myocytes. J Pharmacol Exp Ther, 1996. 277(2): p. 796–804.

    PubMed  CAS  Google Scholar 

  60. Roux, E., et al., Modelling of Ca2+−activated chloride current in tracheal smooth muscle cells. Acta Biotheoretica, 2001. 49(4): p. 291–300.

    Article  PubMed  CAS  Google Scholar 

  61. Marhl, M., et al., Complex calcium oscillations and the role of mitochondria and cytosolic proteins. Biosystems, 2000. 57(2): p. 75–86.

    Article  PubMed  CAS  Google Scholar 

  62. Liu, X. and J.M. Farley, Acetylcholine-induced chloride current oscillations in swine tracheal smooth muscle cells. J Pharmacol Exp Ther, 1996. 276(1): p. 178–86.

    PubMed  CAS  Google Scholar 

  63. Bai, Y. and M.J. Sanderson, Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor. Respir Res, 2006. 7: p. 34.

    Article  PubMed  Google Scholar 

  64. Ouedraogo, N., et al., Effects of intravenous anesthetics on normal and passively sensitized human isolated airway smooth muscle. Anesthesiology, 1998. 88(2): p. 317–26.

    Article  PubMed  CAS  Google Scholar 

  65. Haberichter, T., et al., The influence of different InsP(3) receptor isoforms on Ca(2+) signaling in tracheal smooth muscle cells. Bioelectrochemistry, 2002. 57(2): p. 129.

    Article  PubMed  CAS  Google Scholar 

  66. Marhl, M., D. Noble, and E. Roux, Modeling of molecular and cellular mechanisms involved in Ca2+ signal encoding in airway myocytes. Cell Biochem Biophys, 2006. 46(3): p. 285–302.

    Article  PubMed  CAS  Google Scholar 

  67. Berridge, M.J., P. Lipp, and M.D. Bootman, The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol, 2000. 1(1): p. 11–21.

    Article  PubMed  CAS  Google Scholar 

  68. Babcock, D.F., et al., Mitochondrial participation in the intracellular Ca2+ network. J Cell Biol, 1997. 136(4): p. 833–44.

    Article  PubMed  CAS  Google Scholar 

  69. Drummond, R.M. and F.S. Fay, Mitochondria contribute to Ca2+ removal in smooth muscle cells. Pflugers Arch, 1996. 431(4): p. 473–82.

    Article  PubMed  CAS  Google Scholar 

  70. Fall, C.P. and J.E. Keizer, Mitochondrial modulation of intracellular Ca(2+) signaling. J Theor Biol, 2001. 210(2): p. 151–65.

    Article  PubMed  CAS  Google Scholar 

  71. Wylam, M.E., A. Xue, and G.C. Sieck, Mechanisms of intrinsic force in small human airways. Respir Physiol Neurobiol, 2012. 181(1): p. 99–108.

    Article  PubMed  Google Scholar 

  72. Wang, I.Y., et al., A mathematical analysis of agonist- and KCl-induced Ca(2+) oscillations in mouse airway smooth muscle cells. Biophys J, 2010. 98(7): p. 1170–81.

    Article  PubMed  CAS  Google Scholar 

  73. Bergner, A. and M.J. Sanderson, ATP stimulates Ca2+ oscillations and contraction in airway smooth muscle cells of mouse lung slices. Am J Physiol Lung Cell Mol Physiol, 2002. 283(6): p. L1271–9.

    PubMed  CAS  Google Scholar 

  74. Hagar, R.E. and B.E. Ehrlich, Regulation of the type III InsP(3) receptor by InsP(3) and ATP. Biophysical Journal, 2000. 79(1): p. 271–278.

    Article  PubMed  CAS  Google Scholar 

  75. Moraru, II, et al., Regulation of type 1 inositol 1,4,5-trisphosphate-gated calcium channels by InsP3 and calcium: Simulation of single channel kinetics based on ligand binding and electrophysiological analysis. J Gen Physiol, 1999. 113(6): p. 837–49.

    Article  PubMed  CAS  Google Scholar 

  76. Ramos-Franco, J., et al., Single channel function of recombinant type-1 inositol 1,4,5-trisphosphate receptor ligand binding domain splice variants. Biophys J, 1998. 75(6): p. 2783–93.

    Article  PubMed  CAS  Google Scholar 

  77. Ramos-Franco, J., M. Fill, and G.A. Mignery, Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels. Biophys J, 1998. 75(2): p. 834–9.

    Article  PubMed  CAS  Google Scholar 

  78. Dupont, G. and A. Goldbeter, One-pool model for Ca2+ oscillations involving Ca2+ and inositol 1,4,5-trisphosphate as co-agonists for Ca2+ release. Cell Calcium, 1993. 14(4): p. 311–22.

    Article  PubMed  CAS  Google Scholar 

  79. Morel, J.L., et al., Crucial role of type 2 inositol 1,4,5-trisphosphate receptors for acetylcholine-induced Ca2+ oscillations in vascular myocytes. Arterioscler Thromb Vasc Biol, 2003. 23(9): p. 1567–75.

    Article  PubMed  CAS  Google Scholar 

  80. Parthimos, D., D.H. Edwards, and T.M. Griffith, Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators. Am J Physiol, 1999. 277(3 Pt 2): p. H1119–44.

    PubMed  CAS  Google Scholar 

  81. Roux, E., P. Mbikou, and A. Fajmut, Role of Protein Kinase Network in Excitation-Contraction Coupling in Smooth Muscle Cell, in Protein Kinases, G. Da Silva Xavier, Editor. 2012, InTech: Rijeka. p. 287–320.

    Google Scholar 

  82. Mbikou, P., E. Roux, and A. Fajmut, Couplage excitation-contraction du muscle lisse des voies aeriennes. 2010, Sarrebruck: Éditions universitaires européennes. 144.

    Google Scholar 

  83. Mbikou, P., et al., Contribution of Rho kinase to the early phase of the calcium-contraction coupling in airway smooth muscle. Exp Physiol, 2011. 96(2): p. 240–58.

    Article  PubMed  CAS  Google Scholar 

  84. Hai, C.M. and B. Szeto, Agonist-induced myosin phosphorylation during isometric contraction and unloaded shortening in airway smooth muscle. Am J Physiol, 1992. 262(1 Pt 1): p. L53–62.

    PubMed  CAS  Google Scholar 

  85. Ouedraogo, N., R. Marthan, and E. Roux, The effects of propofol and etomidate on airway contractility in chronically hypoxic rats. Anesth Analg, 2003. 96(4): p. 1035–41.

    Article  PubMed  CAS  Google Scholar 

  86. Hai, C.M. and R.A. Murphy, Regulation of shortening velocity by cross-bridge phosphorylation in smooth muscle. Am J Physiol Cell Physiol, 1988. 255(1): p. C86–94.

    CAS  Google Scholar 

  87. Hai, C.-M. and H.R. Kim, An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction. J Appl Physiol, 2005. 98(4): p. 1356–1365.

    Article  PubMed  CAS  Google Scholar 

  88. Hai, C.M. and R.A. Murphy, Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am. J. Physiol. Cell Physiol., 1988. 254(1): p. C99–106.

    CAS  Google Scholar 

  89. Lauzon, A.M., et al., A multi-scale approach to airway hyperresponsiveness: from molecule to organ. Front Physiol, 2012. 3: p. 191.

    Article  PubMed  Google Scholar 

  90. Berridge, M.J., P.H. Cobbold, and K.S. Cuthbertson, Spatial and temporal aspects of cell signalling. Philos Trans R Soc Lond B Biol Sci, 1988. 320(1199): p. 325–43.

    Article  PubMed  CAS  Google Scholar 

  91. Marhl, M., et al., Importance of cell variability for calcium signaling in rat airway myocytes. Biophys Chem, 2010. 148: p. 42–50.

    Article  PubMed  CAS  Google Scholar 

  92. Burdakov, D. and A. Verkhratsky, Biophysical re-equilibration of Ca2+ fluxes as a simple biologically plausible explanation for complex intracellular Ca2+ release patterns. FEBS Lett, 2006. 580(2): p. 463–8.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Adaptation cardiovasculaire à l’ischémie INSERM U 1034, University of Bordeaux, 1, avenue Magellan U1034, F-33600, Pessac, France

    Etienne Roux

Authors
  1. Etienne Roux
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Etienne Roux .

Editor information

Editors and Affiliations

  1. Albany Medical College Center for Cardiovascular Sciences, Albany, New York, USA

    Yong-Xiao Wang

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Roux, E. (2014). Temporal Aspects of Ca2+ Signaling in Airway Myocytes. In: Wang, YX. (eds) Calcium Signaling In Airway Smooth Muscle Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-01312-1_8

Download citation

Publish with us

Policies and ethics

Search

Navigation