Abstract
The study of the In Vitro biotransformation of ethylhexyl dimethyl PABA (EDP) allowed the identification of two phase I metabolites by gas and liquid chromatography mass spectrometry (GC-MS, LC-MS) analysis, named acid 4-(N,N-dimethylamino) benzoic acid (DMP) and 4-(N-methylamino) benzoic acid (MMP).
Some content of this Chapter has been published in J Chromatogr A (2011) 1218:3013–3021.
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Notes
- 1.
Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products Text with EEA relevance.
- 2.
Prospeckt Technical Note 6 (1996) Strategy for Accelerated On-line Solid Phase Extraction Method Development; Serial Extraction. B. V. Spark Holland.
- 3.
ICH validation of analytical procedures methodology: text and methodology Q2(R1), ICH harmonised tripartite guidelines, Adopted November (2005).
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León González, Z. (2014). Elucidation of the In Vivo Biotransformation Products of Ethylhexyl Dimethyl PABA by Liquid Chromatographic Techniques with Mass Spectrometry Detectors. In: Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-01189-9_7
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