Abstract
Dynamic PET imaging can provide information regarding metabolism, blood flow or other physiological properties of biological tissues beyond what static imaging may offer. A common technique for analyzing these images is compartmental modeling, whose mathematical resolution generally involves solving a set of differential equations using a non-linear least squares algorithm. This paper presents a guide that shows how the R programming language can be used to perform this analysis. To test the suitability of the proposed implementations, a comparison with the PMOD software package has been carried out. We show that the R programming language provides easy to use libraries that can be combined to implement solutions for different compartmental models whose results match those obtained using a commercial tool.
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© 2014 Springer International Publishing Switzerland
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Mateos-Pérez, J.M., Desco, M., Vaquero, J.J. (2014). Tracer Kinetic Modeling with R for Batch Processing of Dynamic PET Studies. In: Roa Romero, L. (eds) XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013. IFMBE Proceedings, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-319-00846-2_75
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DOI: https://doi.org/10.1007/978-3-319-00846-2_75
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-00845-5
Online ISBN: 978-3-319-00846-2
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