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Volume of Tissue Activated in Patients with Parkinson’s Disease from West-Center Region of Colombia Treated with Deep Brain Stimulation

  • Hernán Darío Vargas Cardona
  • Mauricio A. Álvarez
  • Genaro Daza
  • Enrique Guijarro
  • Álvaro Orozco
Conference paper
  • 137 Downloads
Part of the IFMBE Proceedings book series (IFMBE, volume 41)

Abstract

Parkinson’s Disease (PD) is a group of neurological disorders caused by a deficiency of dopamine in a brain structure called Substantia Nigra Reticulata (SNR). The neurosurgical procedure known as Deep Brain Stimulation (DBS) of Subthalamic Nucleus (STN) has proved to be an effective treatment for this disease. DBS modulates neural activity with electric fields. However, the mechanisms regulating the therapeutic effects of DBS are not clear, in fact there is not a full knowledge about the voltage distribution generated in the brain by the stimulating electrodes, what is usually named as Volume of Tissue Activated (VTA). VTA is useful to find the optimal parameters of stimulation, that allow the neurosurgeons to get the best clinical outcomes and minimal side effects. In this work, we applied a methodology to estimate the VTA, based on analysis of diffusion tensor images (DTI) of PD patients from the west-center region of Colombia. DTI are used to characterize the conductivity of brain structures relevant in DBS. The results are consistent to similar studies in other populations.

Keywords

Volume of Tissue Activated (VTA) Parkinson’s Disease (PD) Deep Brain Stimulation (DBS) Subthalamic Nucleus( STN) Diffusion Tensor Images (DTI) 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Hernán Darío Vargas Cardona
    • 1
  • Mauricio A. Álvarez
    • 1
  • Genaro Daza
    • 2
  • Enrique Guijarro
    • 3
  • Álvaro Orozco
    • 1
  1. 1.Department of Electrical EngineeringUniversidad Tecnológica de PereiraPereiraColombia
  2. 2.Instituto de Epilepsia y Parkinson del Eje CafeteroPereiraColombia
  3. 3.I3BHUniversitat Politécnica de ValenciaValenciaSpain

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