Abstract
The dynamic analysis of a cultured cell using Finite Element Analysis is presented to understand the effect of vibration on a cell structure. The model of a spread cell on a culturing plate has been developed as a continuum model and a cellular tensegrity model. Using Finite Element modal analysis, natural frequencies and mode shapes of both models were obtained and compared with each other. Finite Element harmonic response analysis was carried out to investigate the dynamic response of a spread cell exposed to vibration in the frequency range of 1–60 Hz with 1 G acceleration. Both continuum model and tensegrity model showed that the first three natural frequencies appeared in range of 18 ~ 27 Hz and they were in the effective vibration frequency range for bone cell growth. In mode 1–3 the major oscillation was observed in horizontal direction and the resonance occurred when the base vibration frequency was closed to the calculated natural frequency. It is presumed that the optimal frequency for bone cell growth is closely related the natural frequency of cell structures and associated with the resonance of cellular structures. For better understanding resonance of cell structure future studies will consider the damping capability of cell structures.
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Wee, H., Voloshin, A. (2014). Dynamic Analysis of a Spread Cell Using Finite Element Method. In: Barthelat, F., Zavattieri, P., Korach, C., Prorok, B., Grande-Allen, K. (eds) Mechanics of Biological Systems and Materials, Volume 4. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, Cham. https://doi.org/10.1007/978-3-319-00777-9_19
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DOI: https://doi.org/10.1007/978-3-319-00777-9_19
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