Abstract
The nuclear envelope(NE) consists of an inner and an outer membrane enclosing the perinuclear cisterna or perinuclear space. The outer nuclear membrane is studded with ribosomes and continuous with the membrane of the rough endoplasmic reticulum (RER). Therefore, direct continuity exists between the lumen of the nuclear envelope and the rough endoplasmic reticulum, as marked by the lines in panel A. Evidence is ample that the outer nuclear membrane is engaged in protein synthesis and that de novo synthesized proteins are translocated in the perinuclear space. Post-translational modifications on proteins may occur here because of the presence of oligosaccharide-trimming glycosidases (cf. Fig. 18).
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Pavelka, M., Roth, J. (2010). Nuclear Envelope and Rough Endoplasmic Reticulum. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_17
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DOI: https://doi.org/10.1007/978-3-211-99390-3_17
Publisher Name: Springer, Vienna
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