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Fluid Mixing Chaotic Advection and Microarray Analysis

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Analysis and Control of Mixing with an Application to Micro and Macro Flow Processes

Part of the book series: CISM International Centre for Mechanical Sciences ((CISM,volume 510))

Abstract

Chaotic advection has developed into one of the primary tools for analyzing stirring and estimating mixing in laminar flows. Much of the current interest in laminar mixing is focused on smallscale systems, and many of the key applications are in biomedical systems. Here I discuss the use of chaotic advection in designing a mixing protocol to improve DNA microarray analysis. The accuracy and sensitivity of the results can be improved by mixing the solution of unknown DNA across the microarray surface by periodically operating an arrangments of sources and sinks. Optimal operating parameters are predicted using an investigation of chaotic advection in a mathematical model of the system. The ndings of the chaos analysis are consistent with experimental mixing results, supporting the use of chaotic advection for predicting and optimizing mixing when designing fluid-based biomedical devices.

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Author information

Authors and Affiliations

  1. Department of Engineering Science and Mechanics, Virginia Polytechnic and State University, Blacksburg, VA, 24061, USA

    Mark A. Stremler

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  1. Mark A. Stremler
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Editor information

Editors and Affiliations

  1. McGill University, Montreal, Canada

    Luca Cortelezzi

  2. University of California, Santa Barbara

    Igor Mezić

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Stremler, M.A. (2009). Fluid Mixing Chaotic Advection and Microarray Analysis. In: Cortelezzi, L., Mezić, I. (eds) Analysis and Control of Mixing with an Application to Micro and Macro Flow Processes. CISM International Centre for Mechanical Sciences, vol 510. Springer, Vienna. https://doi.org/10.1007/978-3-211-99346-0_9

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  • DOI: https://doi.org/10.1007/978-3-211-99346-0_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-99345-3

  • Online ISBN: 978-3-211-99346-0

  • eBook Packages: EngineeringEngineering (R0)

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