Zusammenfassung
Im Rahmen der Pharmakotherapie von Hörstörungen beobachten wir in den letzten Jahren eine wachsende Differenz zwischen den Erfolgen präklinischer tierexperimenteller Studien und der Pharmakotherapie in der klinischen Praxis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Alexiou C, Arnold W, Fauser C, Schratzenstaller B, Gloddek B, Fuhrmann S, Lamm K (2001) Sudden sensorineural hearing loss: does application of glucocorticoids make sense? Arch Otolaryngol Head Neck Surg. 127: 253–258
Arnold W, Senn P, Hennig M, Michaelis C, Deingruber K, Scheler R, Steinhoff HJ, Riphagen F, Lamm K (2005) Novel slow-and fast-type drug release round-window micro-implants for local drug application to the cochlea: an experimental study in guinea pigs. Audiol Neurootol. 10: 53–63
Bachmann G, Su J, Zumegen C, Wittekindt C, Michel O (2001) [Permeability of the round window membrane for prednisolone-21-hydrogen succinate. Prednisolone content of the perilymph after local administration vs. systemic injection] HNO 49(7): 538–542
Battaglia A, Burchette R, Cueva R (2008) Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 29(4): 453–60
Bird PA, Begg EJ, Zhang M, Keast AT, Murray DP, Balkany TJ (2007) Intratympanic versus intravenous delivery of methylprednisolone to cochlear peri lymph. Otol Neurotol. 28(8): 1124–1130
Canlon B, Meltser I, Johansson P, Tahera Y (2007) Glucocorticoid receptors modulate auditory sensitivity to acoustic trauma. Hear Res. 226(1–2): 61–69
Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE Leary, Sewell WF (2005) Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release 110(1): 1–19
Conlin AE, Parnes LS (2007) Treatment of sudden sensorineural hearing loss: II. A Meta-analysis. Arch Otolaryngol Head Neck Surg. 133(6): 582–586
Desloovere C, Meyer-Breiting E, von Ilberg C (1988) [Randomized double-blind study of therapy of sudden deafness: initial results] HNO. 36(10): 417–422
Eshraghi AA, Adil E, He J, Graves R, Balkany TJ, Van De Water TR (2007) Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss. Otol Neurotol. 28(6): 842–849
Fiering J, Mescher MJ, Leary Swan EE, Holmboe ME, Murphy BA, Chen Z, Peppi M, Sewell WF, McKenna MJ, Kujawa SG, Borenstein JT (2008) Local drug delivery with a self-contained, programmable, microfuidic system. Biomed Microdevices. [Epub ahead of print]
James D P, Eastwood H, Richardson RT, O’Leary SJ (2008) Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation. Audiol Neurootol. 13(2): 86–96
Himeno C, Komeda M, Izumikawa M, Takemura K, Yagi M, Weiping Y, Doi T, Kuriyama H, Miller JM, Yamashita T (2002) Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig. Hear Res. 167(1–2): 61–70
Ho HG, Lin HC, Shu MT, Yang CC, Tsai HT (2004) Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment. Laryngoscope. 114(7): 1184–1189. PMID: 15235345 [Pub Med — indexed for MEDLINE]
Kawamoto K, Ishimoto S, Minoda R, Brough DE, Raphael Y (2003) Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J Neurosci. 23(11): 4395–4400
Kim HH, Addison J, Suh E, Trune DR, Richter CP (2007) Otoprotective effects of dexa methasone in the management of pneumococcal meningitis: an animal study. Laryngoscope. 2007 Jul; 117(7): 1209–1215
Klemm E, Bepperling F, Burschka MA, Mösges R; Study Group (2007) Hemodilution therapy with hydroxyethyl starch solution (130/0.4) in unilateral idiopathic sudden sensorineural hearing loss: a dose-fnding, double-blind, placebo-controlled, international multicenter trial with 210 patients. Otol Neurotol. 28(2): 157–170
Le Prell CG, Hughes LF, Miller JM (2007) Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma. Free Radic Biol Med. 42(9): 1454–1463
Lin HC, Chao PZ, Lee HC (2008) Sudden sensorineural hearing loss increases the risk of stroke: a 5-year follow-up study. Stroke. 39(10): 2744–2748
Martinez-Monedero R, Edge AS (2007) Stem cells for the replacement of inner ear neurons and hair cells. Int J Dev Biol. 51(6&27): 655–661
Merchant SN, Adams JC, Nadol JB Jr (2005) Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 26(2): 151–160
Mynatt R, Hale SA, Gill RM, Plontke SK, Salt AN (2006) Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex. J Assoc Res Otolaryngol. 7(2): 182–193
Parnes LS, Sun AH, Freeman DJ (1999) Corticosteroid pharmacokinetics in the inner ear fuids: an animal study followed by clinical application. Laryngoscope. 109(7 Pt 2): 1–17
Plontke S (2005) Wiederherstellende Verfahren bei gestörtem Hören: konservative Verfahren. Laryngo-Rhino-Otologie 84Suppl 1: 1–42
Plontke S (2009) Innenohrtherapie. In: Reiss (Hrsg.) Facharztwissen HNO-Heilkunde. Springer, Heidelberg, New York
Plontke SK, Salt AN (2006) Simulation of application strategies for local drug delivery to the inner ear. ORL J Otorhinolaryngol Relat Spec. 68(6): 386–392
Plontke S, Zenner HP (2004) Aktuelle Gesichts punkte zu Gehörschäden durch Berufsund Frei zeitlärm. Laryngo-Rhino-Otologie. 83Suppl 1: 122–164
Plontke SK, Plinkert PK, Plinkert B, Koitschev A, Zenner HP, Lowenheim H (2002) Transtympanic endoscopy for drug delivery to the inner ear using a new microendoscope. Adv Otorhinolaryngol. 59: 149–155
Plontke SK, Wood AW, Salt AN (2002) Analysis of gentamicin kinetics in fuids of the inner ear with round window administration. Otol Neurotol. 23(6): 967–974
Plontke SK, Mynatt R, Gill RM, Borgmann S, Salt AN (2007) Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane. Laryngoscope. 2007 Jul; 117(7): 1191–1198
Plontke SK, Biegner T, Kammerer B, Delabar U, Salt AN (2008a) Dexamethasone concentration gradients along scala tympani after application to the round window membrane. Otol Neurotol. 29(3): 401–406
Plontke SK, Mikulec AA, Salt AN (2008b) Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007; 28: 1124–1130. Otol Neurotol. 29 (5): 732–733; author reply 733
Plontke SK, Löwenheim H, Mertens J, Engel C, Meisner C, Weidner A, Zimmermann R, Preyer S, Koitschev A, Zenner HP (2009) Randomized, double blind, placebo controlled trial on the safety and effcacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope. 119(2): 359–369
Probst R, Tschopp K, Lüdin E, Kellerhals B, Podvinec M, Pfaltz CR (1992) A randomized, double-blind, placebo-controlled study of dextran/pentoxifylline medication in acute acoustic trauma and sudden hearing loss. Acta Otolaryngol. 1992; 112(3): 435–443
Rauch SD, Reda DJ (2009) Combined therapy (intratympanic dexamethasone + highdose prednisone taper) for idiopathic sudden sensorineural hearing loss. Otol Neurotol. 30(2): 254–255; author reply 255–256
Salt AN, Gill RM, Plontke SK (2008) Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope. 118(10): 1793–1800
Schwab B, Lenarz T, Heermann R (2004) [Use of the round window micro cath for inner ear therapy — results of a placebo-controlled, prospective study on chronic tinnitus] Laryngorhinootologie. 83: 164–172
Sendowski I, Abaamrane L, Raffn F, Cros A, Clarençon D (2006) Therapeutic effcacy of intra-cochlear administration of methylprednisolone after acoustic trauma caused by gunshot noise in guinea pigs. Hear Res. 221(1–2): 119–127
Sha SH, Qiu JH, Schacht J (2006) Aspirin to prevent gentamicin-induced hearing loss. N Engl J Med. 354(17): 1856–1857
Silverstein H (1999) Use of a new device, the MicroWick, to deliver medication to the inner ear. Ear Nose Throat J. 78(8): 595–598, 600
Stöver T, Yagi M, Raphael Y (1999) Cochlear gene transfer: round window versus cochleostomy inoculation. Hear Res. 136(1–2): 124–130
Suckfuell M, Canis M, Strieth S, Scherer H, Haisch A (2007) Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study. Acta Otolaryngol. 127: 938–942
Takemura K, Komeda M, Yagi M, Himeno C, Izumikawa M, Doi T, Kuriyama H, Miller JM, Yamashita T (2004) Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res. 196(1–2): 58–68
Trune DR (2006) Ion homeostasis and inner ear disease. In: Hamid M, Sismanis A (Hrsg.) Medical Otology and Neurotology: A Clinical Guide to Auditory and vestibular Disorders. Thieme Medical Publishers
Trune DR, Wobig RJ, Kempton JB, Hefeneider SH. (1999) Steroid treatment in young MRL. MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction. Hear Res. 1999 Nov; 137(1–2): 167–173
Van Wijk F, Staecker H, Keithley E, Lefebvre PP (2006) Local perfusion of the tumor necrosis factor alpha blocker infiximab to the inner ear improves autoimmune neurosensory hearing loss. Audiol Neurootol. 11: 357–365
Wang Y, Liberman MC (2002) Restraint stress and protection from acoustic injury in mice. Hear Res. 165(1–2): 96–102
Wei BP, Mubiru S, O’Leary S. (2006) Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev. CD003998
Xenellis J, Papadimitriou N, Nikolopoulos T, Maragoudakis P, Segas J, Tzagaroulakis A, Ferekidis E (2006) Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg. 134(6): 940–945
Ye Q, Tillein J, Hartmann R, Gstoettner W, Kiefer J. (2007) Application of a corticosteroid (Triamcinolon) protects inner ear function after surgical intervention. Ear Hear. 28(3): 361–369
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag/Wien
About this paper
Cite this paper
Plontke, S.K. (2010). Pharmakotherapie bei Hörstörungen — Gegenwärtiger Stand und aktuelle Entwicklungen. In: Plinkert, P.K., Klingmann, C. (eds) Hören und Gleichgewicht. Springer, Vienna. https://doi.org/10.1007/978-3-211-99270-8_3
Download citation
DOI: https://doi.org/10.1007/978-3-211-99270-8_3
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99269-2
Online ISBN: 978-3-211-99270-8
eBook Packages: Medicine (German Language)