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Localized Scleroderma

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Autoimmune Diseases of the Skin

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Summary

Morphea is an uncommon but potentially disabling condition. Abnormalities in immune system parameters, endothelial activation and fibroblast metabolism have been described, but a unifying pathophysiologic model remains to be tested. The clinician is faced with considerable uncertainty when choosing a treatment modality for LS. Given the benign natural progression of plaque type morphea, treatment with topical modalities such as superpotent corticosteroids or calcipotriol is prudent. For more generalized forms of morphea, as well as the linear forms, UVA is currently the best-documented therapeutic modality. In the absence of access to UVA treatment, oral calciferol or systemic immunosuppression may be contemplated. Recent studies support the use of methotrexate with systemic corticosteroids for the management of aggressive disease. The authors have had variable success with PUVA, broadband UVA, and methotrexate in severe disease. Resolution of therapeutic uncertainty must await the organization and completion of controlled trials.

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Authors and Affiliations

  1. Centro Médico San Joaquín, Av. Vicuña Mackenna, 4686, Macul, Chile

    Cristián Vera Kellet MD

  2. Department of Dermatology, The Royal Free Hospital, Pond Street, London, NWS 2QG, UK

    Catherine H. Orteu MD

  3. Division of Dermatology Faculty of Medicine, University of British Columbia, 835 West 10th Avenue, Vancouver BC, V5Z 4E8, Canada

    Jan P. Dutz MD

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  1. Cristián Vera Kellet MD
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  2. Catherine H. Orteu MD
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  3. Jan P. Dutz MD
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Michael Hertl

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Kellet, C.V., Orteu, C.H., Dutz, J.P. (2011). Localized Scleroderma. In: Hertl, M. (eds) Autoimmune Diseases of the Skin. Springer, Vienna. https://doi.org/10.1007/978-3-211-99225-8_7

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