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Eosinophils in Autoimmune Bullous Diseases

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Book cover Autoimmune Diseases of the Skin

Summary

Eosinophils may be present in most of the autoimmune bullous diseases, in particular in BP. In BP, the number of eosinophils as well the levels of eosinophil derived products in the peripheral blood correlate with disease severity. However, the exact mechanisms how eosinophils are recruited and activated as well as their pathogenic role is not fully understood. The detectable eosinophil granule proteins and cytokines point to the possibility that eosinophils play a role in tissue damage, immunomodulation and/or remodeling. It should be noted, however, that the pathogenic role of eosinophils in autoimmune bullous diseases remains unclear. Clinical trials with novel drugs that specifically target eosinophils, cytokines or their receptors may provide new insights into the pathogenesis of these diseases, besides the analysis of clinical efficacy.

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  1. Department of Dermatology, University of Bern, Freiburgstrasse Eingang 14 A-D, CH-3010, Bern, Switzerland

    Dagmar Simon MD

  2. Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010, Bern, Switzerland

    Hans-Uwe Simon MD

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Simon, D., Simon, HU. (2011). Eosinophils in Autoimmune Bullous Diseases. In: Hertl, M. (eds) Autoimmune Diseases of the Skin. Springer, Vienna. https://doi.org/10.1007/978-3-211-99225-8_22

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