Abstract
1. Stop injection/infusion immediately
2. Get extravasation kit
3. Put on (sterile) gloves
4. Replace infusion lead or syringe with 5 ml disposable syringe and aspirate slowly as much as possible of the extravasated drug; Cave! do not exert pressure on extravasation area
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Original articles
Cabriales S, Bresnahan J, Testa D, et al: Extravasation of liposomal daunorubicin in patients with AIDS-associated Kaposi s sarcoma: a report of four cases. Oncol Nurs Forum 25: 67–70, 1998.
Guaglianone P, Chan K, Hanisch R, et al: Phase I clinical trial of liposomal daunorubicin (Daunoxome) in advanced malignancies. Proc ASCO 11: 135, 1992.
Sharma D, Muggia F, Lucci L, et al: Liposomal daunorubicin (VS103): tolerance and clinical effects in AIDS-related Kaposi’s sarcoma (KS) during a phase I study. Proc ASCO 9: 4, 1990.
Secondary literature
Stanley A: Managing complications of chemotherapy administration. In: Allwood M, Stanley A, Wright P (eds) The Cytotoxics Handbook. Radcliffe Medical Press, 4th edition: 119–193, 2002.
Mullin S, Beckwith MC, Tyler LS: Prevention and management of antineoplastic extravasation injury. Hosp Pharm 35: 57–76, 2000.
van Gemmern R: Gewebstoxizität und Paravasatbehandlung neuer Zytostatika. Krankenhauspharmazie 17: 471–473, 1996.
Bertelli G: Prevention and management of extravasation of cytotoxic drugs. Drug Safety 12: 245–255, 1995.
Schneider G: Paravasate von Zytostatika. Diagnostik und Therapie. Aina S. Schneider Verlag, 6th edition: 1–17, 1999.
Dorr RT: Antidotes to vesicant chemotherapy extravasations. Blood Rev 4: 41–60, 1990.
Summary of product characteristics Daunoxome® (Germany), Gilead Sciences, March 2003.
Krämer I, Stützle M: Zytostatika-Paravasation – Wie ist vorzugehen? Krankenhauspharmazie 23: 261–268, 2002.
Jordan K, Grothe W, Schmoll HJ: Paravasation von Zytostatika: Prävention und Therapie. Dtsch Med Wochenschr 130: 33–37, 2005.
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Mader, I., Fürst-Weger, P., Mader, R., Nogler-Semenitz, E., Wassertheurer, S. (2010). Daunorubicin liposomal. In: Extravasation of Cytotoxic Agents. Springer, Vienna. https://doi.org/10.1007/978-3-211-88893-3_27
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