Background Cerebral edema is a common sequelum post traumatic brain injury (TBI). Quantification of the apparent diffusion coefficient (ADC) using diffusion tensor imaging (DTI) may help to characterize the pathophysiology of brain swelling.
Methods Twenty-two patients with moderate-to-severe TBI underwent magnetic resonance (MR) imaging, including DTI, within five days of injury. The mean ADCs in whole brain white matter, whole brain grey matter and entire brain were calculated and compared to twenty-five controls.
Findings A significant decrease in the grey matter ADC (p< 0.001), significant increase in the white matter ADC (p< 0.001) and no significant change in the whole brain ADC (p=0.771) was observed. No significant correlation was found between DTI parameters in any of the three regions of interest (ROI) and GCS, time to scan, intracranial pressure (ICP) before and during the time of the scan, cerebral perfusion pressure at time of scan, or Glasgow Outcome Score (GCS). Conclusions; The decrease in ADC seen in the grey matter is consistent with cytotoxic edema. The increase in ADC in the white matter indicates damage that has led to an overall less restricted diffusion. This study assists in the interpretation of the ADC by showing that the acute changes are different in the whole brain white and grey matter ROIs post TBI.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Albensi BC, Knoblach SM, Chew BG, O’Reilly MP, Faden AI, Pekar JJ (2000) Diffusion and high resolution MRI of traumatic brain injury in rats: time course and correlation with histology. Exp Neurol 162:61–72
Amorini AM, Dunbar JG, Marmarou A (2003) Modulation of aquaporin-4 water transport in a model of TBI. Acta Neurochir Suppl 86:261–263
Barzo P, Marmarou A, Fatouros P, Hayasaki K, Corwin F (1997) Contribution of vasogenic and cellular edema to traumatic brain swelling measured by diffusion-weighted imaging. J Neurosurg 87:900–907
Basser PJ, Pierpaoli C (1996) Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B 111:209–219
Buki A, Povlishock JT (2006) All roads lead to disconnection?– Traumatic axonal injury revisited. Acta Neurochir (Wien) 148:181–193 discussion 193–184
Goetz P, Blamire A, Rajagopalan B, Cadoux-Hudson T, Young D, Styles P (2004) Increase in apparent diffusion coefficient in normal appearing white matter following human traumatic brain injury correlates with injury severity. J Neurotrauma 21:645–654
Huisman TA, Sorensen AG, Hergan K, Gonzalez RG, Schaefer PW (2003) Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury. J Comput Assist Tomogr 27:5–11
Inglese M, Makani S, Johnson G, Cohen BA, Silver JA, Gonen O, Grossman RI (2005) Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study. J Neurosurg 103:298–303
Ke C, Poon WS, Ng HK, Lai FM, Tang NL, Pang JC (2002) Impact of experimental acute hyponatremia on severe traumatic brain injury in rats: influences on injuries, permeability of blood-brain barrier, ultrastructural features, and aquaporin-4 expression. Exp Neurol 178:194–206
Le Bihan D (2003) Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 4:469–480
Le Bihan D (2007) The ‘wet mind’: water and functional neuroimaging. Phys Med Biol 52:R57–R90
Mac Donald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL (2007) Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic braininjury. Exp Neurol 205:116–131
Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6:159–163
Marmarou A (2007) A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22:E1
Marmarou A, Signoretti S, Aygok G, Fatouros P, Portella G (2006) Traumatic brain edema in diffuse and focal injury: cellular or vasogenic? Acta Neurochir Suppl 96:24–29
Marmarou A, Signoretti S, Fatouros PP, Portella G, Aygok GA, Bullock MR (2006) Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries. J Neurosurg 104:720–730
Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007) Analysis of acute traumatic axonal injury using diffusion tensor imaging. Br J Neurosurg 21:340–348
Obenaus A, Robbins M, Blanco G, Galloway NR, Snissarenko E, Gillard E, Lee S, Curras-Collazo M (2007) Multi-modal magnetic resonance imaging alterations in two rat models of mild neurotrauma. J Neurotrauma 24:1147–1160
Povlishock JT, Katz DI (2005) Update of neuropathology and neurological recovery after traumatic brain injury. J Head Trauma Rehabil 20:76–94
Smith SM (2002) Fast robust automated brain extraction. Hum Brain Mapp 17:143–155
Van Putten HP, Bouwhuis MG, Muizelaar JP, Lyeth BG, Berman RF (2005) Diffusion-weighted imaging of edema following traumatic brain injury in rats: effects of secondary hypoxia. J Neurotrauma 22:857–872
Vizuete ML, Venero JL, Vargas C, Ilundain AA, Echevarria M, Machado A, Cano J (1999) Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. Neurobiol Dis 6:245–258
vtkCISG Version www.image-registration.com
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2008 Springer-Verlag/Wien
About this paper
Cite this paper
Newcombe, V.F.J. et al. (2008). Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma. In: Steiger, H.J. (eds) Acta Neurochirurgica Supplements. Acta Neurochirurgica Supplementum, vol 102. Springer, Vienna. https://doi.org/10.1007/978-3-211-85578-2_47
Download citation
DOI: https://doi.org/10.1007/978-3-211-85578-2_47
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-85577-5
Online ISBN: 978-3-211-85578-2
eBook Packages: MedicineMedicine (R0)