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New Solutions for the Heart pp 145–166Cite as

The Endothelium As Target for Interventions

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Abstract

Cardiovascular research has recognized rather late that the endothelium of the heart is an important organ that locally regulates coronary perfusion and cardiac function by paracrine secretion of NO and vasoactive peptides (Linz et al.1992). Therefore, cardioplegic solutions in general and storage solutions in cardiac transplantation in particular, are now critically discussed with respect to preservation of both the integrity and function of myocytes and endothelial cells.

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Abbreviations

ACE:

angiotensin converting enzyme

BH4 :

(6R)-5,6,7,8-tetrahydrobiopterin

eNOS:

endothelial nitric oxide synthase

I/R:

ischemia/reperfusion

iNOS:

inducible NO synthase

nNOS:

neuronal NO synthase

NO:

nitric oxide

O −2 :

superoxide

SOD:

superoxide dismutase.

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Acknowledgement

The authors thank the Ludwig Boltzmann Gesellschaft, 1010 Vienna, for the continuous support. The authors have reproduced parts and Fig. 1 of their contribution to British Journal of Pharmacology (Podesser and Hallström 2007 and panel parts of Figs. 2, 3, and 4 of the contribution to Cardiovascular Research (Hallström et al. 2008)

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Authors and Affiliations

  1. Institute of Physiological Chemistry, Center of Physiological Medicine, Medical University of Graz, Graz, Austria

    Seth Hallström

  2. The Ludwig Boltzmann Cluster for Cardiovascular Research, Medical University of Vienna, Vienna, Austria

    Bruno K. Podesser

  3. Department of Cardiac Surgery, Landesklinikum St. Pölten, Propst Führerstr. 4, 3100, St. Pölten, Austria

    Bruno K. Podesser

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  1. Seth Hallström
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  2. Bruno K. Podesser
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Correspondence to Bruno K. Podesser .

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Editors and Affiliations

  1. , Department of Cardiac Surgery, Landesklinikum St. Pölten, Propst Führerstraße 4, St. Pölten, 3100, Austria

    Bruno K. Podesser

  2. St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, United Kingdom

    David J. Chambers

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Hallström, S., Podesser, B.K. (2011). The Endothelium As Target for Interventions. In: Podesser, B., Chambers, D. (eds) New Solutions for the Heart. Springer, Vienna. https://doi.org/10.1007/978-3-211-85548-5_9

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  • DOI: https://doi.org/10.1007/978-3-211-85548-5_9

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