Abstract
Heart transplantation is now the best treatment for patients with severe and refractory end-stage cardiac failure (American Heart Association stage D) (Hunt et al. 2005). It improves both patient survival and quality of life. However, this therapy is threatened by the increasing scarcity of suitable human donor hearts. In 1995, 4,399 heart transplants were reported worldwide to ISHLT (Taylor et al.) Over a 10-year period, this number has fallen by 30% to 3,095. The fall in the UK has been more dramatic, reducing by 74% in the last 10 years (393 in 1997 to 101 on 2007) (UK Transplant activity report), and numbers are expected to continue to decrease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baroldi, G., Di Pasquale, G., Silver, M. D., Pinelli, G., Lusa, A. M., & Fineschi, V. (1997). Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: a morphometric study. J Heart Lung Transplant, 16(10), 994–1000.
Collins, J.M., Moainie, L.S., Griffith, P.B., & Poston, S.R. (2008). Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool. Eur J Cardiothorac Surg, 34(2), 318–325.
Galinanes, M., & Hearse, J.D. (1994). Brain-death-induced cardiac contractile dysfunction: studies of possible neurohormonal and blood-borne mediators. J Mol Cell Cardiol, 26(4), 481–498.
Halejcio-Delophont, P., Siaghy, M.E., Devaux, Y., Ungureanu-Longrois, D., Richoux, P.J., Beck, B., et al. (1998). Increase in myocardial interstitial adenosine and net lactate production in brain-dead pigs: an in vivo microdialysis study. Transplantation, 66(10), 1278–1284.
Hunt A.S., W.A., Chin H.M.,Feldman M.A., Francis G.S., Ganiats T.G., Jessup M., Konstam M.A., Mancini D.M., Michl K.,Oates J.A., Rahko P.S., Silver M.A., Stevenson L.W., Yancy C.W., Antman E.M., Smith S.C. Jr, Adams C.D., Anderson J.L., Faxon D.P., Fuster V., Halperin J.L., Hiratzka L.F. ,Jacobs A.K., Nishimura R,Ornato JP,Page RL,Riegel B (2005). ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society.,American College of Cardiology,American Heart Association Task Force on Practice Guidelines,American College of Chest Physicians,International Society for Heart and Lung Transplantation,Heart Rhythm [Journal Article, Practice Guideline,Research Support, N.I.H., Extramural,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov’t, P.H.S.]. Circulation, Sep 2005, is. 112/,(12(e154-235)), 1524–4539.
Kharbanda, K.R., Mortensen, M.U., White, A.P., Kristiansen, B.S., Schmidt, R.M., Hoschtitzky, A.J., et al. (2002). Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation, 106(23), 2881–2883.
Kloner, A.R., Speakman, T.M., & Przyklenk, K. (2002). Ischemic preconditioning: a plea for rationally targeted clinical trials. Cardiovasc Res, 55(3), 526–533.
Labarrere, A.C., Pitts, D., Halbrook, H., & Faulk, P.W. (1994). Tissue plasminogen activator, plasminogen activator inhibitor-1, and fibrin as indexes of clinical course in cardiac allograft recipients. An immunocytochemical study. Circulation, 89(4), 1599–1608.
Lima, B., Rajagopal, K., Petersen, P.R., Shah, S.A., Soule, B., Felker, M.G., et al. (2006). Marginal cardiac allografts do not have increased primary graft dysfunction in alternate list transplantation. Circulation, 114(1 suppl), I-27–32.
Menasche, P., Termignon, L.J., Pradier, F., Grousset, C., Mouas, C., Alberici, G., et al. (1994). Experimental evaluation of Celsior, a new heart preservation solution. Eur J Cardiothorac Surg, 8(4), 207–213.
Novitzky, D., Wicomb, N.W., & Cooper, K.D. C. (1984). Electrocardiographic, hemodynamic & endocrine changes occurring during experimental brain death in the Chacma baboon. J Heart Transplant, 4(1), 63–69.
Ojeda-Rivero, R., Hernandez-Fernand, A., Dominguez-Roldan, M.J., Calderon, E., Ruiz, M., Lage, E., et al. (2002). Experimental treatment with beta blockers of hemodynamic and myocardial changes in organ donors. Transplant Proc, 34(1), 185–186.
Organ Procurement and Transplantation Network, D.U.partment of Health & Human Services, 2009. Data: Deceased Donors Recovered in the U.S. by Circumstance of Death : Donors Recovered : January 1, 1988 – May 31, 2009. http://optn.transplant.hrsa.gov
Satchithanada, D., Stoica, S., White, P., Charman, S., Luckraz, H., Schofield, P., et al. (2001). Systolic right ventricular dysfunction in good donor hearts – a normal finding? . J Heart Lung Transplant, 20(2), 243.
Shivalkar, B., Van Loon, J., Wieland, W., Tjandra-Maga, B.T., Borgers, M., Plets, C., et al. (1993). Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation, 87(1), 230–239.
Stoica, C.S., Satchithananda, K.D., Dunning, J., & Large, R.S. (2001). Two-decade analysis of cardiac storage for transplantation. Eur J Cardiothorac Surg, 20(4), 792–798.
Stoica, C.S., Satchithananda, K.D., Atkinson, C., White, A.P., Redington, N.A., Goddard, M., et al. (2003). The energy metabolism in the right and left ventricles of human donor hearts across transplantation. Eur J Cardiothorac Surg, 23(4), 503–512.
Stoica, C.S., Satchithananda, K.D., White, A.P., Parameshwar, J., Redington, N.A., & Large, R.S. (2004). Noradrenaline use in the human donor and relationship with load-independent right ventricular contractility. Transplantation, 78(8), 1193–1197.
Stringham, C.J., Southard, H.J., Hegge, J., Triemstra, L., Fields, L.B., & Belzer, O.F. (1992). Limitations of heart preservation by cold storage. Transplantation, 53(2), 287–294.
Szabo, G., Hackert, T., Sebening, C., Vahl, F.C., & Hagl, S. (1999). Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. Ann Thorac Surg, 67(1), 18–25; discussion 25–26.
Szabo, G., Hackert, T., Sebening, C., Melnitchuk, S., Vahl, F.C., & Hagl, S. (2000). Role of neural and humoral factors in hyperdynamic reaction and cardiac dysfunction following brain death. J Heart Lung Transplant, 19(7), 683–693.
Taylor, O.D., Edwards, B.L., Boucek, M.M., Trulock, P.E., Aurora, P., Christie, J., et al. (2007). Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report--2007. J Heart Lung Transplant, 26(8), 769–781.
UK Transplant activity report (2008) http://www.uktransplant.org.uk/ukt/statistics/transplant_activity_report/current_activity_reports/ukt/tx_activity_report_2008_uk_pp26-32.pdf.
Wheeldon, R.D., Potter, D.C., Jonas, M., Wallwork, J., & Large, R.S. (1994). Using “unsuitable” hearts for transplantation. Eur J Cardiothorac Surg, 8(1), 7–9.
Wicomb, N.W., Cooper, K.D., Novitzky, D., & Barnard, N.C. (1984). Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system. Ann Thorac Surg, 37(3), 243–248.
Yellon, M.D., & Hausenloy, D.J. (2007). Myocardial reperfusion injury. N Engl J Med, 357(11), 1121–1135.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag/Wien
About this chapter
Cite this chapter
Barker, A., Large, S. (2011). Protection During Heart Transplantation. In: Podesser, B., Chambers, D. (eds) New Solutions for the Heart. Springer, Vienna. https://doi.org/10.1007/978-3-211-85548-5_8
Download citation
DOI: https://doi.org/10.1007/978-3-211-85548-5_8
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-85547-8
Online ISBN: 978-3-211-85548-5
eBook Packages: MedicineMedicine (R0)