Abstract
The central nervous system (CNS) may be affected by a lymphoma in many circumstances (Table 1). Lymphomas are divided into Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (NHL) with a primary extranodal presentation in 5% and 30% of the cases. Extranodal NHL may develop in the gastrointestinal tract, skin, bone, upper respiratory tract, thyroid, breast, testis or CNS. Primary central nervous system lymphoma (PCNSL) is an extranodal lymphoma accounting for 1% to 2% of extranodal NHL, occurring in the brain, leptomeninges, spinal cord, or eyes and remaining confined to the CNS. Regardless of their origin, CNS lymphomas are no longer the curiosities they were in decades past and provide multiple challenges to physicians.
Keywords
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Abrey LE, Batchelor TT, Ferreri AJ, Gospodarowicz M, Pulczynski EJ, Zucca E, Smith JR, Korfel A, Soussain C, DeAngelis LM, Neuwelt EA, O’Neill BP, Thiel E, Shenkier T, Graus F, van den Bent M, Seymour JF, Poortmans P, Armitage JO, Cavalli F (2005) Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol 23(22): 5034–5043
Bataille B, Delwail V, Menet E, Vandermarcq P, Ingrand P, Wager M, Guy G, Lapierre F (2000) Primary intracerebral malignant lymphoma: report of 248 cases. J Neurosurg 92(2): 261–266
Batchelor T, Loeffler JS (2006) Primary CNS lymphoma. J Clin Oncol 24(8): 1281–1288
Bessell EM, Hoang-Xuan K, Ferreri AJ, Reni M (2007) Primary central nervous system lymphoma: biological aspects and controversies in management. Eur J Cancer 43(7): 1141–1152
Ferreri AJ, Blay JY, Reni M, Pasini F, Spina M, Ambrosetti A, Calderoni A, Rossi A, Vavassori V, Conconi A, Devizzi L, Berger F, Ponzoni M, Borisch B, Tinguely M, Cerati M, Milani M, Orvieto E, Sanchez J, Chevreau C, Dell’Oro S, Zucca E, Cavalli F (2003) Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol 21(2): 266–272
Ferreri AJ, Reni M (2007) Primary central nervous system lymphoma. Crit Rev Oncol Hematol 63(3): 257–268
Frankfurt O, Rosen ST (2004) Mechanisms of glucocorticoid-induced apoptosis in hematologic malignancies: updates. Curr Opin Oncol 16(6): 553–563
Go JL, Lee SC, Kim PE (2006) Imaging of primary central nervous system lymphoma. Neurosurg Focus 21(5): E4
Gunduz K, Pulido JS, McCannel CA, O’Neill BP (2006) Ocular manifestations and treatment of central nervous system lymphomas. Neurosurg Focus 21(5): E9
Hoang-Xuan K, Camilleri-Broet S, Soussain C (2004) Recent advances in primary CNS lymphoma. Curr Opin Oncol 16(6): 601–606
Loiseau H, Cuny E, Vital A, Cohadon F (2000) Central nervous system lymphomas. Adv Tech Stand Neurosurg 26: 79–124
Omuro AM, Abrey LE (2006) Chemotherapy for primary central nervous system lymphoma. Neurosurg Focus 21(5): E12
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag/Wien
About this chapter
Cite this chapter
Loiseau, H. (2009). Management of Lymphomas. In: Sindou, M. (eds) Practical Handbook of Neurosurgery. Springer, Vienna. https://doi.org/10.1007/978-3-211-84820-3_35
Download citation
DOI: https://doi.org/10.1007/978-3-211-84820-3_35
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-84819-7
Online ISBN: 978-3-211-84820-3
eBook Packages: MedicineMedicine (R0)