Skip to main content

Antidepressiva

  • Chapter

Zusammenfassung

Unter dem Begriff „Antidepressiva“ (der ältere Begriff „Thymoleptika“ wird heute nicht mehr verwendet) wird eine chemisch und pharmakologisch heterogene Klasse von Neuro-Psychopharmaka zusammengefasst, die ursprünglich vorwiegend bei Patienten mit depressiven Symptomen eingesetzt wurde, heute aber eine weit über die depressive Störung hinausgehende therapeutische Anwendung findet. So werden diese Wirkstoffe auch bei Zwangs-, generalisierten Angst-, Panik-, phobischen und Ess-Störungen, mutistischen Verhaltensweisen und ADHS mit gutem klinischen Erfolg eingesetzt. Aufgrund der Na+-Kanal-blockierenden Wirkung der trizyklischen Antidepressiva eignen sich diese auch zur Behandlung neuropathischer Schmerzen. Der Oberbegriff Antidepressiva ist deshalb heute formal gesehen nicht mehr ganz korrekt.

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literaturverzeichnis B.1.6.1 Weiterführende Literatur

  • Bandelow B, Heise CA, Banaschewski T, Rothenberger A (2006) Handbuch Psychopharmaka für das Kindes-und Jugendalter. Deutsche Überarbeitung von Bezchlibnyk-Butler KZ, Virani AS (Eds) Clinical Handbook of Psychotropic Drugs for Children and Adolescents. Hogrefe Verlag, Göttingen Bonn Bern Wien

    Google Scholar 

  • Bazire S (ed) (2007) Psychotropic drug directory. Bath Press, Quay Books Division, Bath

    Google Scholar 

  • Benkert O, Hippius H (Hrsg) (2007) Kompendium der Psychiatrischen Pharmakotherapie, 6. Aufl. Springer, Berlin

    Google Scholar 

  • Bezchlibnyk-Butler KZ, Jeffries JJ, Virani AS (eds) (2007) Clinical handbook of psychotropic drugs, 17. Aufl. Hogrefe & Huber Publishers, Seattle Toronto Göttingen Bern

    Google Scholar 

  • Bezchlibnyk-Butler KZ, Virani AS (eds) (2007) Clinical handbook of psychotropic drugs for children and adolescents, 2. Aufl. Hogrefe & Huber Publishers, Seattle Toronto Göttingen Bern

    Google Scholar 

  • Holsboer DF, Gründer G, Benkert O (2008) Handbuch der Psychopharmakotherapie. Springer Medizin Verlag, Heidelberg

    Book  Google Scholar 

  • Nissen G, Fritze J, Trott GE (Hrsg) (2004) Psychopharmaka im Kindes-und Jugendalter, 2. Aufl. Urban & Fischer, München

    Google Scholar 

  • Riederer P, Laux G, Pöldinger W (Hrsg) (2002) Neuro-Psychopharmaka. Ein Therapie-Handbuch, Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer. Springer, Wien New York

    Google Scholar 

Ausgewählte Literatur

  • Alderman J, Wolkow R, Fogel IM (2006) Drug concentration monitoring with tolerability and efficacy assessments during open-label, long-term sertraline treatment of children and adolescents. J Child Adolesc Psychopharmacol 16: 117–129

    Article  PubMed  Google Scholar 

  • Ambrosini PJ (2000) A review of pharmacotherapy of major depression in children and adolescents. Psychiat Serv 51: 627–633

    Article  CAS  Google Scholar 

  • Apter A, Lipschitz A, Fong R, Carpenter DJ, Krulewicz S, Davies JT, Wilkinson C, Perera P, Metz A (2006) Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine. J Child Adolesc Psychopharmacol 16: 77–90

    Article  PubMed  Google Scholar 

  • Asbahr FR, Castillo AR, Ito LM, Latorre MR, Moreira MN, Lotufo-Neto F (2005) Group cognitive-behavioral therapy versus sertraline for the treatment of children and adolescents with obsessive-compulsive disorder J Am Acad Child Adolesc Psychiatry 44: 1128–1136

    Article  PubMed  Google Scholar 

  • Avci A, Diler RS, Kibar M, Sezgin F (1999) Comparison of moclobemide and placebo in young adolescents with major depressive disorder. Ann Med Sci 8: 31–40

    Google Scholar 

  • Baumann P, Hiemke C, Ulrich S, Eckermann G, Gaertner I, Gerlach M, Kuss H-J, Laux G, Müller-Oerlinghausen B, Rao ML, Riederer P, Zernig G (2004) The AGNP-TDM expert group consensus guidelines: Therapeutic drug monitoring in Psychiatry. Pharmacopsychiatry 37: 243–265

    Article  PubMed  CAS  Google Scholar 

  • Bech (2001) Meta-analysis of placebo-controlled trials with mirtazapine using the core items of the Hamilton Depression Scale as evidence of a pure antidepressive effect in the short-term treatment of major depression. Int J Neuropsychopharamcol 4: 337–345

    CAS  Google Scholar 

  • Birmaher B, Waterman GS, Ryan N, Cully M, Balach L, Ingram J, Brodsky M (1994) Fluoxetine for childhood anxiety disorders. J Am Acad Child Adolesc Psychiatry 33: 993–999

    PubMed  CAS  Google Scholar 

  • Birmaher B, Waterman GS, Ryan ND, Perel J, McNabb J, Balach L, Beaudry MB, Nasr FN, Karambelkar J, Elterich G, Quintana H, Williamson DE, Rao U (1998) Randomized, controlled trial of amitriptyline versus placebo for adolescents with „treatment-resistant“ major depression. J Am Acad Child Adolesc Psychiatry 37: 527–535

    Article  PubMed  CAS  Google Scholar 

  • Boulos C, Kutcher S, Marton P, Simeon J, Ferguson B, Roberts N (1991) Response to desipramine treatment in adolescent major depression. Psychopharmacol Bull 27: 59–65

    PubMed  CAS  Google Scholar 

  • Braconnier A, Coent RL, Cohen D (2003) Paroxetine versus clomopramine in adolescents with severe major depression: a double-blind randomized, multicenter trial. J Child Am Child Adolesc Psychiatry 42: 22–29

    Article  Google Scholar 

  • Brent D, Emslie G, Clarke G, Wagner KD, Asarnow JR, Keller M, Vitiello B, Ritz L, Iyengar S, Abebe K, Birmaher B, Ryan N, Kennard B, Hughes C, DeBar L, McCracken J, Strober M, Suddath R, Spirito A, Leonard H, Melhem N, Porta G, Onorato M, Zelazny J (2008) Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. JAMA 299: 901–913

    Article  PubMed  CAS  Google Scholar 

  • Bridge JA, Jyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, Ren L, Brent DA (2007) Clinical response and risk for suicidal ideation and suicide attempts in pediatric antidepressant treatment. JAMA 297: 1683–1696

    Article  PubMed  CAS  Google Scholar 

  • Carlson JS, Kratochwill TR, Johnston HF (1999) Sertraline treatment of 5 children diagnosed with selective mutism: a single-case research trial. J Child Adolesc Psychopharmacology 9: 293–306

    Article  CAS  Google Scholar 

  • Cohen D, Gerardin P, Mazet P, Purper-Ouakil D, Flament MF (2004) Pharmacological treatment of adolescent major depression. J Child Adolesc Psychopharmacol 14: 19–31

    Article  PubMed  Google Scholar 

  • Cohen JA, Mannarino AP, Perel JM, Staron V (2007) A pilot randomized controlled trial of combined trauma-focused CBT and sertraline for childhood PTSD symptoms. J Am Acad Child Adolesc Psychiatry 46: 811–819

    Article  PubMed  Google Scholar 

  • Cook EH, Wagner KD, March JS, Biedermann J, Landau P, Wolkow R, Messig M (2001) Longterm sertraline treatment of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adol Psychiatry 40: 1174–1181

    Article  Google Scholar 

  • De Jonghe F, Ravelli DP, Tuynman-Qua H (1991) A randomized, double-blind study of fluoxetine and maprotiline in the treatment of major depression. Pharmacopsychiatry 24: 62–67

    Article  PubMed  Google Scholar 

  • DeVeaugh-Geiss J, Moroz G, Biederman J, Cantwell D, Fontaine R, Greist JH, Reichler R, Katz R, Landau P (1992) Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder — a multicenter trial. J Am Acad Child Adolesc Psychiatry 31: 45–49

    Article  PubMed  CAS  Google Scholar 

  • Donnelly CL, Wagner KD, Rynn M, Ambrosini P, Landau P, Yang R, Wohlberg CJ (2006) Sertraline in children and adolescents with major depressive disorder. J Am Acad Child Adolesc Psychiatry 45: 1162–1170

    Article  PubMed  Google Scholar 

  • Dugas M, Mouren MC, Halfon O, Moron P (1985) Treatment of childhood and adolescent depression with mianserin. Acta Psychiatr Scand 320: 48–53

    Article  CAS  Google Scholar 

  • Edwarts JG, Anderson I (1999) Systematic review and guide to selection of selektive serotonin reuptake inhibitors. Drugs 57: 507–533

    Article  Google Scholar 

  • Emslie GJ, Rush AJ, Weinberg WA, Kowatch RA, Hughes CW, Carmody T, Rintelmann J (1997) A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Ach Gen Psychiatry 54: 1031–1037

    CAS  Google Scholar 

  • Emslie GJ, Heiligenstein JH, Wagner KD, Hoog SL, Ernest DE, Brown E, Nilsson M, Jacobson JG (2002) Fluoxetine for acute treatment of depression in children and adolescents a placebo-controlled, randomized clinical trial. J Am Acad Child Adolesc Psychiatry 41: 1205–1215

    Article  PubMed  Google Scholar 

  • Emslie GJ, Wagner KD, Kutcher S, Krulewicz S, Fong R, Carpenter DJ, Lipschitz A, Machin A, Wilkinson C (2006) Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, doubleblind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 45: 709–719

    Article  PubMed  Google Scholar 

  • Emslie GJ, Findling RL, Yeung PP, Kunz NR, Li Y (2007) Venlafaxine ER for the treatment of pediatric subjects with depression: results of two placebo-controlled trials. J Am Acad Child Adolesc Psychiatry 46: 479–488

    Article  PubMed  Google Scholar 

  • Emslie GJ, Kennard BD, Mayes TL, Nightingale-Teresi J, Carmody T, Hughes CW, Rush AJ, Tao R, Rintelmann JW (2008) Fluoxetine versus placebo in preventing relapse of major depression in children and adolescents. Am J Psychiatry 165: 459–467

    Article  PubMed  Google Scholar 

  • Entsuah AR, Huang H, Thase ME (2001) Response and remission rates in different subpopulations with major depressive disorder administered venlafaxine, selective serotonin reuptake inhibitors, or placebo. J Clin Psychiatry 62: 869–877

    PubMed  CAS  Google Scholar 

  • Fegert JM, Herpertz-Dahlmann B (2005) Serotoninwiederaufnahmehemmer im Kindes-und Jugendalter. Warnhinweise der Behörden, Analyseergebnisse und Empfehlungen. Nervenarzt 76: 1330–1339

    Article  PubMed  CAS  Google Scholar 

  • Findling RL, McNamara NK, O’Riordan MA, Reed MD, Demeter CA, Branicky LA, Blumer JL (2003) An open-label pilot study of St. John’s wort in juvenile depression. J Am Acad Child Adolesc Psychiatry 42: 908–914

    Article  PubMed  Google Scholar 

  • Flament MF, Rapoport JL, Berg CJ, Sceery W, Kilts C, Mellström B, Linnoila M (1985) Clomipramine treatment of childhood obsessive-compulsive disorder. A double-blind controlled study. Arch Gen Psychiatry 42: 977–983

    PubMed  CAS  Google Scholar 

  • Frey R, Schreinzer D, Stimpfl T, Vycudilik W, Berzlanovich A, Kasper S (2002) Letale Intoxikationen mit Antidepressiva und Neuroleptika. Analyse im Zusammenhang mit den Verordnungen in Wien von 1991 bis 1997. Nervenarzt 73: 629–636

    Article  PubMed  CAS  Google Scholar 

  • Geller B, Cooper TB, McCombs HG, Graham D, Wells J (1989) Double-blind, placebo-controlled study of nortriptyline in depressed children using a „fixed plasma level“ design. Psychopharmacol Bull 25: 101–108

    PubMed  CAS  Google Scholar 

  • Geller B, Cooper TB, Graham DL, Marsteller FA, Bryant DM (1990) Double-blind placebo-controlled study of nortriptyline in depressed adolescents using a „fixed plasma level“ design. Psychopharmacol Bull 26: 85–90

    PubMed  CAS  Google Scholar 

  • Geller B, Cooper TB, Graham DL, Fetner HH, Marsteller FA, Wells JM (1992) Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6-to 12-year-olds with major depressive disorder. J Am Acad Child Adolesc Psychiatry 31: 34–44

    PubMed  CAS  Google Scholar 

  • Geller DA, Hoog SL, Heiligenstein JH, Ricardi RK, Tamura R, Kluszynski S, Jacobson JG; Fluoxetine Pediatric OCD Study Team (2001) Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: a placebo-controlled clinical trial. J Am Acad Child Adolesc Psychiatry 40: 733–779

    Google Scholar 

  • Geller DA, Biedermann J, Stewart SE, Mullin B, Martin A, Spencer T, Faraone SV (2003) A metaanalysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder. Am J Psychiatry 160: 1919–1928

    Article  PubMed  Google Scholar 

  • Geller DA, Wagner KD, Emslie G, Murphy T, Carpenter DJ, Wetherhold E, Perera P, Machin A, Gardiner C (2004) Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 43: 1387–1396

    Article  PubMed  Google Scholar 

  • Gibbons RD, Hur K, Bhaumik DK, Mann JJ (2006) The relationship between antidepressant prescription rates and rate of early adolescent suicide. Am J Psychiatry 163: 1898–1904

    Article  PubMed  Google Scholar 

  • Glazener CM, Evans JH, Peto RE (2003) Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 3: CD002117

    Google Scholar 

  • Goodyer IM, Dubicka B, Wilkinson P, Kelvin R, Roberts C, Byford S, Breen S, Breen S, Ford C, Barrett B, Leech A, Rothwell J, White L, Harrington R (2008) A randomised controlled trial of cognitive behaviour therapy in adolescents with major depression treated by selective serotonin reuptake inhibitors. The ADAPT trial. Health Technol Assess 12: 1–80

    Google Scholar 

  • Haapasalo-Pesu KM, Vuola T, Lahelma L, Marttunen M (2004) Mirtazapine in the treatment of adolescents with major depression: an open-label, multicenter pilot study. J Child Adolesc Psychopharmacol 14: 175–184

    Article  PubMed  Google Scholar 

  • Hammad TA, Laughren T, Racoosin J (2006) Suicidality in pediatric patients treated with antidepressant drugs. Arch Gen Psychiatry 63: 332–339

    Article  PubMed  CAS  Google Scholar 

  • Hazell P, O’Connell D, Heathcote D, Robertson J, Henry D (1995) Efficacy of tricyclic drugs in treating child and adolescent depression: a metaanalysis. BMJ 310: 897–901

    PubMed  CAS  Google Scholar 

  • Hazell P, O’Connell D, Heathcote D, Henry D (2002) Tricyclic drugs for depression in children and adolescents. Cochrane Database Syst Rev 2: CD002317

    Google Scholar 

  • Heiser P, Remschmidt H (2002) Die selektiven Serotonin-Wiederaufnahmehemmer und die neueren Antidepressiva in der Kinder-und Jugendpsychiatrie. Z Kinder-Jugendpsychiatr 30: 173–183

    Article  CAS  Google Scholar 

  • Henry JA, Alexander CA, Sener EK (1995) Relative mortality from overdose of antidepressants. Br Med J 310: 221–224

    CAS  Google Scholar 

  • Hetrick S, Merry S, McKenzie J, Sindahl P, Proctor M (2007) Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents. Cochrane Database Syst Rev 3: CD004851

    Google Scholar 

  • Holtkamp K, Konrad K, Kaiser N, Ploenes Y, Heussen N, Grzella I, Herpertz-Dahlmann B (2005) A retrospective study of SSRI treatment in adolescent anorexia nervosa: insufficient evidence for efficacy. J Psychiatr Res 39: 303–310

    Article  PubMed  CAS  Google Scholar 

  • Holtmann M, Bölte S, Poustka F (2006) Suizidalität bei depressiven Kindern und Jugendlichen unter Behandlung mit selektiven Serotoninwiederaufnahmehemmern. Review und Metaanalyse verfügbarer plazebokontrollierter Doppelblindstudien. Nervenarzt 77: 1332–1337

    Article  PubMed  CAS  Google Scholar 

  • Isacsson G, Holmgren P, Ahlner J (2005) Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr Scand 111: 286–290

    Article  PubMed  CAS  Google Scholar 

  • Kaakeh Y, Stumpf JL (2008) Treatment of selective mutism: focus on selective serotonin reuptake inhibitors. Pharmacotherapy 28: 214–224

    Article  PubMed  CAS  Google Scholar 

  • Kashani JH, Shekim WO, Reid JC (1984) Amitriptyline in children with major depressive disorder: a double-blind crossover pilot study. J Am Acad Child Psychiatry 23: 348–351

    PubMed  CAS  Google Scholar 

  • Keller MB, Ryan ND, Strober M, Klein RG, Kutcher SP, McCafferty JP (2001) Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial. J Child Am Child Adolesc Psychiatry 40: 762–772

    Article  CAS  Google Scholar 

  • Klein RG, Mannuzza S, Koplewicz HS, Tancer NK, Shah M, Liang V, Davies M (1998) Adolescent depression: controlled desipramine treatment and atypical features. Depress Anxiety 7: 15–31

    Article  PubMed  CAS  Google Scholar 

  • Kolevzon A, Mathewson KA, Hollander E (2006) Selective serotonin reuptake inhibitors in autism: a review of efficacy and tolerability. J Clin Psychiatry 67: 407–414

    PubMed  CAS  Google Scholar 

  • Kutcher S, Boulos C, Ward B, Marton P, Simeon J, Ferguson HB, Szalai J, Katic M, Roberts N, Dubois C (1994) Response to desipramine treatment in adolescent depression: a fixed-dose, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 33: 686–694

    Article  PubMed  CAS  Google Scholar 

  • Kye CH, Waterman GS, Ryan ND, Birmaker B, Williamson DE, Iyengar S, Dachille S (1996) A randomized, controlled trial of amitriptyline in the acute treatment of of adolescent major depression. J Am Acad Child Adolesc Psychiatry 35: 1139–1144

    Article  PubMed  CAS  Google Scholar 

  • Leonard HL, Swedo SE, Rapoport JL, Koby EV, Lenane MC, Cheslow DL, Hamburger SD (1989) Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. Arch Gen Psychiatry 46: 1088–1092

    PubMed  CAS  Google Scholar 

  • Lesch K-P (2002) Exkurs: Wirkmechanismus antidepressiver Behandlung: Genexpression und synaptische Plastizität. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 31–55

    Google Scholar 

  • Liebowitz MR, Turner SM, Piacentini J, Beidel DC, Clarvit SR, Davies SO, Graae F, Jaffer M, Lin SH, Sallee FR, Schmidt AB, Simpson HB (2002) Fluoxentine in children and adolescents with OCD: a placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 41: 1431–1438

    Article  PubMed  Google Scholar 

  • Mandoki MW, Tapia MR, Tapia MA, Sumner GS, Parker JL (1997) Venflafaxine in the treatment of children and adolescents with major depression. Psychopharmacol Bull 33: 149–154

    PubMed  CAS  Google Scholar 

  • Maneeton N, Srisurapanont M (2000) Tricyclic antidepressants for depressive disorders in children and adolescents: a meta-analysis of randomized-controlled trials. J Med Assoc Thai 83: 1367–1374

    PubMed  CAS  Google Scholar 

  • March JS, Biederman J, Wolkow R, Safferman A, Mardekian J, Cook EH, Cutler NR, Dominguez R, Sallee FR, Wagner KD, Steiner H (1998) Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. JAMA 280: 1752–1756

    Article  PubMed  CAS  Google Scholar 

  • March J, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, Domino M, McNulty S, Vitiello B, Severe J; Treatment for Adolescents With Depression Study (TADS) Team (2004) Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial. JAMA 292: 807–820

    Article  PubMed  CAS  Google Scholar 

  • March JS, Klee BJ, Kremer CM (2006) Treatment benefit and the risk of suicidality in multicenter, randomized, controlled trials of sertraline in children and adolescents. J Child Adolesc Psychopharmacol 16: 91–102

    Article  PubMed  Google Scholar 

  • March JS, Silva S, Petrycki S, Curry J, Wells K, Fairbank J, Burns B, Domino M, McNulty S, Vitiello B, Severe J (2007a) The Treatment for Adolescents with Depression Study (TADS): long-term effectiveness and safety outcomes. Arch Gen Psychiatry 64: 1132–1143

    Article  PubMed  CAS  Google Scholar 

  • March JS, Entusah AR, Rynn M, Albano AM, Tourian KA (2007b) A randomized controlled trial of venlafaxine ER versus placebo in pediatric social anxiety disorder. Biol Psychiatry 62: 1149–1154

    Article  PubMed  CAS  Google Scholar 

  • Masi G, Mucci M, Millepiedi S (2001) Separation anxiety disorder in children and adolescents: epidemiology, diagnosis and management. CNS Drugs 15: 93–104

    Article  PubMed  CAS  Google Scholar 

  • McGrath PJ, Rabkin JG, Stewart JW, Harrison W, Quitkin FM, Markowitz J (1985) Placebo-controlled study of mianserin in depressed outpatients. Neuropsychobiology 14: 128–132

    Article  PubMed  CAS  Google Scholar 

  • Moreno C, Arango C, Parellada M, Shaffer D, Bird H (2007) Antidepressants in child and adolescent depression: where are the bugs? Acta Psychiatr Scand 115: 184–195

    Article  PubMed  CAS  Google Scholar 

  • Mozes T, Meiri G, Ben-Amity G, Sabbagh M, Weizman A (2005) Reboxetine as an optional treatment for hyperkinetic conduct disorder: a prospective open-label trial. J Child Adolesc Psychopharmacol 15: 259–269

    Article  PubMed  Google Scholar 

  • Mrakotsky C, Masek B, Biederman J, Raches D, Hsin O, Forbes P, de Moor C, DeMaso DR, Gonzalez-Heydrich J (2008) Prospective open-labeled pilot trial of mirtazapine in children and adolescents with social phobia. J Anxiety Disord 22: 88–97

    Article  PubMed  Google Scholar 

  • Müller WE, Möller HJ (2002a) Einteilung von Antidepressiva. In: Riederer P, Laux G, Pödinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 82–83

    Google Scholar 

  • Müller WE, Möller HJ (2002b) Die einzelnen Antidepressivaklassen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 87–93

    Google Scholar 

  • Müller WE, Möller HJ (2002c) Einteiung nach klinisch-therapeutischen Wirkprofilen, sedierende vs. eher nicht sedierende Antidepressiva. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 94–96

    Google Scholar 

  • Müller WE, Möller HJ (2002d) Antidepressiva. Biochemisch-pharmakologische Wirkungsmechanismen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 84–87

    Google Scholar 

  • Mula M, Trimble MR (2003) Pharmacokinetic interactions between antiepileptics and antidepressant drugs. World J Biol Psychiatry 4: 21–24

    Article  PubMed  Google Scholar 

  • Nevéus T (2006) Reboxetine in therapy-resistant enuresis: results and pathogenetic implications. Scand J Urol Nephrol 40: 31–34

    Article  PubMed  CAS  Google Scholar 

  • Papanikolaou K, Richardson C, Pehlivanidis A, Papadopoulou-Daifoti Z (2006) Efficacy of antidepressants in child and adolescent depression: a metaanalytic study. J Neural Transm 113: 399–415

    Article  PubMed  CAS  Google Scholar 

  • Pathak S, Kratochvil CJ, Rogers GM, Silva S, Vitiello B, Weller EB, March JS (2005) Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study. Curr Psychiatry Rep 7: 429–434

    Article  PubMed  Google Scholar 

  • Pediatric OCD Treatment Study (POTS) Team (2004) Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA 292: 1969–1976

    Article  Google Scholar 

  • Petti TA, Law W 3rd (1982) Imipramine treatment of depressed children: a double-blind pilot study. J Clin Psychopharmacol 2: 107–110

    PubMed  CAS  Google Scholar 

  • Pössel P, Hautzinger M (2006) Effekte pharmakologischer und psychotherapeutischer Interventionen auf Depressionen bei Kindern und Jugendlichen. Z Kinder Jugendpsychiatr Psychother 34: 243–255

    Article  PubMed  Google Scholar 

  • Posey DJ, Guenin KD, Kohn AE, Swiezy NB, Mc-Dougle CJ (2001) A naturalistic open-label study of mirtazapine in autistic and other pervasive development disorders. J Child Adolesc Psychopharmacol 11: 267–277

    Article  PubMed  CAS  Google Scholar 

  • Preskorn SH, Weller EB, Hughes CW, Weller RA, Bolte K (1987) Depression in prepubertal children: dexamethasone nonsuppression predicts differential response to imipramine vs. placebo. Psychopharmacol Bull 23: 128–133

    PubMed  CAS  Google Scholar 

  • Prince JB, Wilens TE, Biederman J, Spencer TJ, Millstein R, Polisner DA, Bostic JQ (2000) A controlled study of nortriptyline in children and adolescents with attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 10: 193–204

    Article  PubMed  CAS  Google Scholar 

  • Puig-Antich J, Perel JM, Lupatkin W, Chambers WJ, Tabrizi MA, King J, Goetz R, Davies M, Stiller RL (1987) Imipramine in prepubertal major depressive disorders. Arch Gen Psychiatry 44: 81–89

    PubMed  CAS  Google Scholar 

  • Ratner S, Laor N, Bronstein Y, Weizman A, Toren P (2005) Six-week open-label reboxetine treatment ment in children and adolescents with attentiondeficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 44:428–433

    Article  PubMed  Google Scholar 

  • Riddle MA, Scahill L, King RA, Hardin MT, Anderson GM, Ort SI, Smith JC, Leckman JF, Cohen DJ (1992) Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 31: 1062–1069

    Article  PubMed  CAS  Google Scholar 

  • Riddle MA, Reeve EA, Yaryura-Tobias JA, Yang HM, Claghorn JL, Gaffney G, Greist JH, Holland, D, McConville BJ, Pigott T, Walkup JT (2001) Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J Am Acad Child Adolesc Psychiatry 40: 222–229

    Article  PubMed  CAS  Google Scholar 

  • Riggs PD, Mikulich-Gilbertson SK, Davies RD, Lohman M, Klein C, Stover SK (2007) A randomized controlled trial of fluoxetine and cognitive behavioral therapy in adolescents with major depression, behavior problems, and substance use disorders. Arch Pediatr Adolesc Med 161: 1026–1034

    Article  PubMed  Google Scholar 

  • Rynn MA, Siqueland L, Rickels K (2001) Placebocontrolled trial of sertraline in the treatment of children with generalized anxiety disorder. Am J Psychiatry 158: 2008–2014

    Article  PubMed  CAS  Google Scholar 

  • Rynn M, Wagner KD, Donnelly C, Ambrosini P, Wohlberg CJ, Landau P, Yang R (2006) Long-term sertraline treatment of children and adolescents with major depressive disorder. J Child Adolesc Psychopharmacol 16: 103–116

    Article  PubMed  Google Scholar 

  • Rynn MA, Riddle MA, Yeung PP, Kunz NR (2007) Efficacy and safety of extended-release venlafaxine in the treatment of generalized anxiety disorder in children and adolescents: two placebo-controlled trials. Am J Psychiatry 164: 290–300

    Article  PubMed  Google Scholar 

  • Sallee FR, Vrindavanam NS, Deas-Nesmith D, Carson SW, Sethuraman G (1997) Pulse intravenous clomipramine for depressed adolescents: double-blind, controlled trial. Am J Psychiatry 155: 995

    Google Scholar 

  • Schlamp D (1999) Remergil in der Kinder-und Jugendpsychiatrie. Psychiatrie und Dialog 3: 8–9

    Google Scholar 

  • Segool NK, Carlson JS (2007) Efficacy of cognitive-behavioral and pharmacological treatments for children with social anxiety. Depress Anxiety 25: 620–631

    Article  Google Scholar 

  • Shah R, Uren Z, Baker A, Majeed A (2001) Deaths from antidepressants in England and Wales 1993–1997: Analysis of a new national database. Psychol Med 31: 1203–1210

    Article  PubMed  CAS  Google Scholar 

  • Simeon JG, Dinicola VF, Ferguson HB, Copping W (1990) Adolescent depression: a placebo-controlled fluoxetine treatment study and followup. Prog Neuropsychopharmacol Biol Psychiatry 14: 791–795

    Article  PubMed  CAS  Google Scholar 

  • Simeon J, Nixon MK, Milin R, Jovanovic R, Walker S (2005) Open-label pilot study of St. John’s wort in adolescent depression. J Child Adolesc Psychopharmacol 15: 293–301

    Article  PubMed  Google Scholar 

  • Smith D, Dempster C, Glanville J, Freemantle N, Anderson I (2002) Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: a meta-analysis. Br J Psychiatry 180: 396–404

    Article  PubMed  Google Scholar 

  • Spencer T, Biederman J, Coffey B, Geller D, Crawford M, Bearman SK, Tarazi R, Faraone SV (2002) A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 59:649–656

    Article  PubMed  CAS  Google Scholar 

  • Steingard RJ, Zimnitzky B, DeMaso DR, Bauman ML, Bucci JP (1997) Sertraline treatment of transition-associated anxiety and agitation in children with autistic disorder. J Child Adolesc Psychopharmacol 7: 9–15

    Article  PubMed  CAS  Google Scholar 

  • Storosum JG, Elferink AJ, van Zwieten BJ, van den Brink W, Gersons BP, van Strik R, Broekmans AW (2001) Short-term efficacy of tricyclic antidepressants revisited: a meta-analytic study. Eur Neuropsychopharmacol 11: 173–180

    Article  PubMed  CAS  Google Scholar 

  • Szegedi A, Wetzel H, Angersbach D, Philipp M, Benkert O (1997) Response to treatment in minor and major depression: results of a doubleblind comparative study with paroxetine and maprotiline. J Affect Disord 45: 167–178

    Article  PubMed  CAS  Google Scholar 

  • TDM-Gruppe der AGNP (2008) Wie wirksam sind Antidepressiva? Zur Bedeutung von Plasma-konzentrations-Wirksamkeitsstudien. Psychopharmako therapie 15: 162–163

    Google Scholar 

  • Tehrani-Doost M, Moallemi S, Shahrivar Z (2008) An open-label trial of reboxetine in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 18: 179–184

    Article  PubMed  Google Scholar 

  • Thomé-Souza MS, Kuczynski E, Valente KD (2007) Sertraline and fluoxetine: safe treatments for children and adolescents with epilepsy and depression. Epilepsy Behav 10: 417–425

    Article  PubMed  Google Scholar 

  • Toren P, Ratner S, Laor N, Lerer-Amisar D, Weizman A (2005) A possible antienuretic effect of reboxetine in children and adolescents with attention deficit/hyperactivity disorder: case series. Neuropsychobiology 51: 239–242

    Article  PubMed  Google Scholar 

  • Toren P, Ratner S, Weizman A, Lask M, Ben-Amitay G, Laor N (2007) Reboxetine maintenance treatment in children with attention-deficit/hyperactivity disorder: a long-term follow-up study. J Child Adolesc Psychopharmacol 17: 803–812

    Article  PubMed  Google Scholar 

  • Trott GE, Friese HJ, Menzel M, Nissen G (1992) Use of moclobemide in children with attention deficit hyperactivity disorder. Psychopharmacology 106 [Suppl 1]: 134–136

    Article  Google Scholar 

  • Ulloa RE, Nicolini H, Avila M, Fernández-Guasti A (2007) Age onset subtypes of obsessive compulsive disorder: differences in clinical response to treatment with clomipramine. J Child Adolesc Psychopharmacol 17: 85–96

    PubMed  Google Scholar 

  • Ulrich S, Baumann P, Havemann-Reinecke U, Hiemke C, Laux G, Müller-Oerlinghausen B, Riederer P, Zernig G und die Arbeitsgruppe TDM der Arbeitsgemeinschaft Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) (2007). Psychopharmakotherapie 15: 67–74

    Google Scholar 

  • Usala T, Clavenna A, Zuddas A, Bonati M (2008) Randomised controlled trials of selective serotonin reuptake inhibitors in treating depression in children and adolescents: a systematic review and meta-analysis. Eur Neuropsychopharmacol 18: 62–73

    Article  PubMed  CAS  Google Scholar 

  • Versiani M, Amrein R, Stabl M (1997) Moclobemide and imipramine in chronic depression (dysthymia): an international double-blind, placebocontrolled trial. International Collaborative Study Group. Int Clin Psychopharmacol 12: 183–193

    PubMed  CAS  Google Scholar 

  • Vollmayr B, Gass P, Henn FA (2002) Modellvorstellungen zur Ätiopathogenese affektiver Störungen. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapie-Handbuch. Band 3: Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer, zweite, neubearb. Aufl. Springer, Wien New York, 1–11

    Google Scholar 

  • Von Knorring AL, Olsson GI, Thomsen PH, Lemming OM, Hultén A (2006) A randomized, double-blind, placebo-controlled study of citalopram in adolescents with major depressive disorder. J Clin Psychopharmacol 26: 311–315

    Article  CAS  Google Scholar 

  • Wagner KD, Ambrosini P, Rynn M, Wohlberg C, Yang R, Greenbaum MS, Childress A, Donnelly C, Deas D; Sertraline Pediatric Depression Study Group (2003) Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials. JAMA 290: 1033–1041

    Article  PubMed  CAS  Google Scholar 

  • Wagner KD, Robb AS, Findling RL, Jin J, Gutierrez MM, Heydorn WE (2004a) A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents. Am J Psychiatry 161: 1079–1083

    Article  PubMed  Google Scholar 

  • Wagner KD, Berard R, Stein MB, Wetherhold E, Carpenter DJ, Perera P, Gee M, Davy K, Machin A (2004b) A multicenter, randomized, doubleblind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Arch Gen Psychiatry 61: 1153–1162

    Article  PubMed  CAS  Google Scholar 

  • Walsh BT, Seidman SN, Sysko R, Gould M (2002) Placebo response in studies of major depression: Variable, substantial, and growing. J Am Med Ass 287: 1840–1847

    Article  Google Scholar 

  • Weber W, Vander Stoep A, McCarty RL, Weiss NS, Biederman J, McClellan J (2008) Hypericum perforatum (St John’s wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial. JAMA 299: 2633–2641

    Article  PubMed  CAS  Google Scholar 

  • Weller TE, Weller RA, Davis GP (2000) Use of venlafaxine in children and adolescents: a review of current literature. Depression and Anxiety [Suppl 12]: 1: 85–99

    Article  Google Scholar 

  • Werneke U, Horn O, Taylor DM (2004) How effective is St John’s wort? The evidence revisited. J Clin Psychiatry 65: 611–617

    Article  PubMed  Google Scholar 

  • Whittington C, Kendall T, Fonagy P, Cottrell D, Cotgrove A, Boddington E (2004) Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet 363: 1341–1345

    Article  PubMed  CAS  Google Scholar 

  • Wilcox CS, Cohn JB, Katz BB, Mijares CP, Guarino JJ, Panagides J, DeFrancisco DF (1994) A double-blind, placebo-controlled study comparing mianserin and amitriptyline in moderately depressed outpatients. Int Clin Psychopharmacol 9: 271–279

    Article  PubMed  CAS  Google Scholar 

  • Williams JW Jr, Mulrow CD, Chiquette E, Noël PH, Aguilar C, Cornell J (2000) A systematic review of newer pharmacotherapies for depression in adults: evidence report summary. Ann Intern Med 132: 743–756

    PubMed  CAS  Google Scholar 

  • Woggon B (1993) The role of moclobemide in endogenous depression: a survey of recent data. Int Clin Psychopharmacology 7: 137–139

    Article  CAS  Google Scholar 

  • Wong IC, Besag FM, Santosh PJ, Murray ML (2004) Use of selective serotonin reuptake inhibitors in children and adolescents. Drug Saf 27: 991–1000

    Article  PubMed  CAS  Google Scholar 

  • Wood JG, Crager JL, Delap CM, Heiskell KD (2007) Beyond methylphenidate: Nonstimulant medications for youth with ADHD. J Attent Disord 11: 341–350

    Article  Google Scholar 

  • Zuckerman ML, Vaughan BL, Whitney J, Dodds A, Yakhkind A, MacMillan C, Raches D, Pravdova I, DeMaso DR, Beardslee WR, Gonzalez-Heydrich J (2007) Tolerability of selective serotonin reuptake inhibitors in thirty-nine children under age seven: a retrospective chart review. J Child Adolesc Psychopharmacol 17: 165–174

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag/Wien

About this chapter

Cite this chapter

Taurines, R., Wewetzer, C., Warnke, A., Gerlach, M. (2009). Antidepressiva. In: Gerlach, M., Warnke, A., Mehler-Wex, C., Walitza, S., Wewetzer, C. (eds) Neuro-Psychopharmaka im Kindes- und Jugendalter. Springer, Vienna. https://doi.org/10.1007/978-3-211-79275-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-79275-9_6

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-79274-2

  • Online ISBN: 978-3-211-79275-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics