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Effect of hyperbaric oxygen on patients with traumatic brain injury

  • Conference paper
Book cover Reconstructive Neurosurgery

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 101))

Abstract

Hyperbaric oxygen therapy (HBOT) is the medical therapeutic use of oxygen at a higher atmospheric pressure. The United States Food and Drug Administration have approved several clinical applications for HBOT, but HBOT in traumatic brain injury (TBI) patients has still remained in controversial. The purpose of our study is to evaluate the benefit of HBOT on the prognosis of subacute TBI patients. We prospectively enrolled 44 patients with TBI from November 1, 2004 to October 31, 2005. The study group randomly included 22 patients who received HBOT after the patients’ condition stabilization, and the other 22 corresponding condition patients were assigned into the matched control group who were not treated with HBOT. The clinical conditions of the patients were evaluated with the Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) before and 3 to 6 months after HBOT. The GCS of the HBOT group was improved from 11.1 to 13.5 in average, and from 10.4 to 11.5 (p<0.05) for control group. Among those patients with GOS = 4 before the HBOT, significant GOS improvement was observed in the HBOT group 6 months after HBOT. Based on this study, HBOT can provide some benefits for the subacute TBI patients with minimal adverse side effects.

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Authors and Affiliations

  1. Department of Neurosurgery, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan

    J. W. Lin, C. M. Lin, K. S. Hung, W. Y. Chen, L. Wei, C. P. Ko & Y. K. Su

  2. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    J. W. Lin, C. M. Lin & Wen-Ta Chiu M.D., Ph.D.

  3. Institute of Biomédical Engineering, National Yang-Ming University, Taipei, Taiwan

    J. T. Tsai

  4. Department of Radiation-oncology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan

    J. T. Tsai

  5. Department of Urology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan

    L. M. Lee

  6. Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan

    L. M. Lee & Wen-Ta Chiu M.D., Ph.D.

  7. Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan

    C. C. Hung

Authors
  1. J. W. Lin
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  2. J. T. Tsai
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  3. L. M. Lee
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  4. C. M. Lin
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  5. C. C. Hung
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  6. K. S. Hung
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  7. W. Y. Chen
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  8. L. Wei
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  9. C. P. Ko
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  10. Y. K. Su
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  11. Wen-Ta Chiu M.D., Ph.D.
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.

    Wen-Ta Chiu

  2. Department of Neurosurgery, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.

    Yung-Hsiao Chiang

  3. Department of Neurosurgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan, R.O.C.

    Ming-Chien Kao  & Ching-Chang Hung  & 

  4. Center for Neuropsychiatry, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.

    Shinn-Zong Lin

  5. Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, R.O.C.

    Han-Jung Chen

  6. Department of Rehabilitation Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan, R.O.C.

    Simon F. T. Tang

  7. National Institute on Drug Abuse, National Institute of Health, Baltimore, USA

    Barry J. Hoffer

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© 2008 Springer-Verlag

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Lin, J.W. et al. (2008). Effect of hyperbaric oxygen on patients with traumatic brain injury. In: Chiu, WT., et al. Reconstructive Neurosurgery. Acta Neurochirurgica Supplementum, vol 101. Springer, Vienna. https://doi.org/10.1007/978-3-211-78205-7_25

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  • DOI: https://doi.org/10.1007/978-3-211-78205-7_25

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-78204-0

  • Online ISBN: 978-3-211-78205-7

  • eBook Packages: MedicineMedicine (R0)

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