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Arfs and Arls: models for Arf family members in membrane traffic at the Golgi

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The Golgi Apparatus

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Abstract

The ADP-ribosylation factor (Arf) family GTPases are highly conserved ~20 kDa GTP-binding proteins that play a number of roles in the regulation of cellular physiology, most relevant here is that they act to recruit soluble proteins to a membrane surface and coordinate the assembly of multi-protein complexes that are required for the biogenesis of nascent carriers of mem- brane traffic. The Arfs can also recruit and directly activate lipid-modifying enzymes, providing important functional links between localized changes in lipid composition and protein assemblies. The Arf family GTPases and their interactions have been the subject of a recent book (Kahn 2004) and reviews (Gillingham and Munro 2007; Inoue and Randazzo 2007). Molecular aspects of Arf family members acting at the Golgi and models for their actions are summarized in this chapter.

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Authors and Affiliations

  1. Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd., Atlanta, GA, 30322, USA

    Richard A. Kahn

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  1. Richard A. Kahn
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  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud Laboratory of Intracellular Traffic, S. Maria Imbaro (Chieti), Italy

    Alexander A. Mironov

  2. Department of Cell Biology and Ultrastructure Research Institute of Histology and Embryology Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

    Margit Pavelka

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© 2008 Springer-Verlag/Wien

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Kahn, R.A. (2008). Arfs and Arls: models for Arf family members in membrane traffic at the Golgi. In: Mironov, A.A., Pavelka, M. (eds) The Golgi Apparatus. Springer, Vienna. https://doi.org/10.1007/978-3-211-76310-0_8

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