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Direct protein transduction method to cerebral arteries by using 11R: new strategy for the treatment of cerebral vasospasm after subarachnoid haemorrhage

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 104))

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References

  1. Asoh S, Ohsawa I, Mori T, Katsura K, Hiraide T, Katayama Y, Kimura M, Ozaki D, Yamagata K, Ohta S (2002) Protection against ischemic brain injury by protein therapeutics. PNAS 99(26): 17107–17112

    Article  CAS  Google Scholar 

  2. Chen AFY, Jiang S-W, Crotty TB, Tsutsui M, Smith LA, O’Brien T, Katusic ZS (1997) Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci USA 94: 12568–12573

    Article  CAS  Google Scholar 

  3. Dorsch NW (2002) Therapeutic approaches to vasospasm in subarachnoid hemorrhage. Curr Opin Crit Care 8: 128–133

    Article  Google Scholar 

  4. Frankel A, Pabo C (1988) Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55(6): 1189–1193

    Article  CAS  Google Scholar 

  5. Green M, Loewenstein PM (1988) Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 55(6): 1179–1188

    Article  CAS  Google Scholar 

  6. Heistad DD, Faraci FM (1996) Gene therapy for cerebral vascular disease. Stroke 27: 1688–1693

    Article  CAS  Google Scholar 

  7. Inoue M, Tomizawa K, Matsushita M, Lu Y-F, Yokoyama T, Yanai H, Takashima A, Kumon H, Matsui H (2006) p53 Protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells. Eur Urol 49: 161–168

    Article  CAS  Google Scholar 

  8. Matsui H, Tomizawa K, Lu YF, Matsushita M (2003) Protein therapy: in vivo protein transduction by polyarginine (11R) PTD and subcellular targeting delivery. Curr Protein Pept Sci 4(2): 151–157

    Article  CAS  Google Scholar 

  9. Matsushita M, Tomizawa K, Moriwaki A, Li ST, Terada H, Matsui H (2001) A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation. J Neurosci 21(16): 6000–6007

    Article  CAS  Google Scholar 

  10. Muhonen MG, Ooboshi H, Welsh MJ, Davidson BL, Heistad DD (1997) Gene transfer to cerebral blood vessels after subarachnoid hemorrhage. Stroke 28(4): 822–828

    Article  CAS  Google Scholar 

  11. Michiue H, Tomizawa K, Wei F-Y, Matsushita M, Lu YF, Ichikawa T, Tamiya T, Date I, Matsui H (2005) The NH2 terminus of influenza virus hemagglutinin-2 subunit peptides enhances the antitumor potency of polyarginine-mediated p53 protein transduction. J Biol Chem 280(9): 8285–8289

    Article  CAS  Google Scholar 

  12. Ono S, Date I, Onoda K, Shiota T, Ohmoto T, Ninomiya Y, Asari S, Morishita R (1998) Decoy administration of NF-kappaB into the subarachnoid space for cerebral angiopathy. Hum Gene Ther 9(7): 1003–1011

    Article  CAS  Google Scholar 

  13. Ono S, Komuro T, Macdonald RL (2002) Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J Neurosurg 96(6): 1094–1102

    Article  CAS  Google Scholar 

  14. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285(5433): 1569–1572

    Article  CAS  Google Scholar 

  15. Schwarze SR, Hruska KA, Dowdy SF (2000) Protein transduction: unrestricted delivery into all cells? Trends Cell Biol 10: 290–295

    Article  CAS  Google Scholar 

  16. Takenobu T, Tomizawa K, Matsushita M, Li ST, Moriwaki A, Lu YF, Matsui H (2002) Development of p53 protein transduction therapy using membrane-permeable peptides and the application to oral cancer cells. Mol Cancer Ther 1: 1043–1049

    CAS  PubMed  Google Scholar 

  17. Templeton NS, Lasic DD (1999) New directions in liposome gene delivery. Mol Biotechnol 11: 175–180

    Article  CAS  Google Scholar 

  18. Verma IM, Somia N (1997) Gene therapy-promises, problems and prospects. Nature (Lond) 389: 239–242

    Article  CAS  Google Scholar 

  19. Khurana VG, Meyer FB (2003) Translational paradigms in cerebrovascular gene transfer. J Cereb Blood Flow Metab 23: 1251–1262

    Article  CAS  Google Scholar 

  20. Wadia JS, Stan RV, Dowdy SF (2004) Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 10: 310–315

    Article  CAS  Google Scholar 

  21. Wu HY, Tomizawa K, Matsushita M, Lu YF, Li ST, Matsui H (2003) Poly-arginine-fused calpastatin peptide, a living cell membrane-permeable and specific inhibitor for calpain. Neurosci Res 47(1):131–135

    Article  CAS  Google Scholar 

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Correspondence to Tomoyuki Ogawa .

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© 2008 Springer-Verlag

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Ogawa, T. et al. (2008). Direct protein transduction method to cerebral arteries by using 11R: new strategy for the treatment of cerebral vasospasm after subarachnoid haemorrhage. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_31

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  • DOI: https://doi.org/10.1007/978-3-211-75718-5_31

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75717-8

  • Online ISBN: 978-3-211-75718-5

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