Abstract
Endothelin converting enzyme (ECE) inhibitor CGS26303 has been shown to be effective on SAH-induced cerebral vasospasm. However, there is no data related to CGS 26303 having a blocking effect of adhesion molecules. Therefore, the aim of this study was to investigate the effect of CGS 26303 on SAH-induced vasospasm and the plasma levels of ICAM, VCAM, and E-selectin. Male rabbits (n=36) were allocated into four groups (9 in each group): 1) control group (group C), no SAH; 2) group of SAH (group Sa), SAH only; 3) group of SAH plus vehicle (group Sv) and; 4) group of SAH plus CGS 26303 (group Sc). Administration of CGS 26303 30 mg/kg i.v. was initiated 1 h after SAH, and subsequently effected at 12, 24, and 36 h post SAH. All animals were sacrificed 48 h post SAH, and plasma levels of intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), and E-selectin levels were examined. ICAM-1 level in group 4 (SAH with CGS 26303 treatment) was significantly lower than those in groups 2 (SAH only) and 3 (SAH plus vehicle) (p<0.001). ICAM-1 level in the SAH with CGS 26303 treatment group (group 4) did not differ significantly from that of the control group. However, VCAM-1 levels showed no significant difference between the groups and CGS26303 administration did not decrease the E-selectin level following SAH. We concluded that the anti-spastic effect of CGS 26303 may partially be mediated by reversing increased ICAM-1 levels after SAH.
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© 2008 Springer-Verlag
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Lin, C.L. et al. (2008). Attenuation of intercellular adhesion molecule-1 and cerebral vasospasm in rabbits subjected to experimental subarachnoid haemorrhage by CGS 26303. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_26
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DOI: https://doi.org/10.1007/978-3-211-75718-5_26
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