Abstract
A segmental nerve defect is still best be treated by autologous nerve graft. However, besides its donor side morbidity, extensive nerve defects of peripheral nerves or the brachial plexus often cannot be completely treated due to missing quantity of autologous nerve graft material. Thus two solution are possible: first, incomplete reconstruction — the abandoned nerve trunk is used as additional source of autologous graft material (ulnar nerve in complete brachial plexus palsy), or second, the application of new reconstruction techniques, such as nerve distraction [1], tubes [7] or nerve allografts [3, 9, 14]. Nerve distraction is still in the laboratory phase [1, 11]. Nerve tubes should not be chosen in cases of mixed nerve and=or defect larger than 10mm [2]. Thus the nerve allograft still seems to be the best substitute.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Anjou de B, Allieu Y, Cenac P, Sanz J (1989) Expansion nerveuse. Ann Chir Main 8 336–337
Chiu DTW, Strauch B (1990) A prospective clinical evaluation of autogenous vein grafts used as a nerve conduit for distal sensory nerve defects of 3 cm or less. Plast Reconstr 86: 928–934
Comtet J-J (19881) Is there a future for nerve homograft? In: Brunelli GA (ed) Textbook of microsurgery. Masson, Milano, pp 629–632
Hierner R (1999) Das allogene modifizierte Kabeltransplantat vom Neugeborenen. Medizinische Hochschule Hannover, Habilitationsschrift
Lassner F, Schaller E, Steinhoff G, Wonigeit K, Walter GF, Berger A (1989) Cellular mechanisms of rejection and regeneration in peripheral nerve allografts. Transplantation 48: 386–392
Lassner F, Becker MH-I, Führer S, Walter GF, Berger A (1996) Die zeitlich begrenzte Immunsuppression am allogenen Nerventrans-plantat der Ratte. Handchir Mikrochir Plast Chir 28: 176–180
Lundborg G (1988) Nerve injury and repair. Churchill Livingstone, Edinburgh
Mackinnon SE, Hudson AR, Falk RE, Kline D, Hunter D (1984) Peripheral nerve allograft: an assessment of regeneration across pretreated nerve allografts. Neurosurg 15: 690–693
Mackinnon SE, Hudson AR, Bain IB, Falk RE, Hunter DA (1987) The peripheral nerve allograft: an assessment of regeneration in the immunosuppressed host (invited Discussion by Yaremchuk M.J.) Plast Reconstr Surg 79: 436–445
Mahowald MB, Silver J, Ratcheson RA (1988) The ethical options in transplanting fetal tissue. Hastings Center Report 9–15
Milner RH (1989) The effect of tissue expansion on peripheral nerves. Br J Plast Surg 42: 414–421
Pollard JD, Fitzpatrick L (1973) A comparison of the effects of irradiation and immunosupressive agents on regeneration through peripheral nerve allografts: an ultrastructural study. Acta Neuropath (Berl) 23: 166–180
Ruwe PA, Trumble TE (1990) A functional evaluation of cryopreserved peripheral nerve autografts. J Reconstr Microsurg 6: 239–244
Schaller E, Lassner F, Becker M, Walter GF, Berger A (1991) Regeneration of autologous nerve grafts in a rat genetic model: preliminary report. 1 Reconstr Microsurg 7: 9–12
Singh R, Medrelse K, Stefanko S (1984) Role of tissue typing on preserved nerve allografts. Exp Neurology 83: 659–663
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag
About this paper
Cite this paper
Berger, A., Hierner, R., Walter, G.F. (2007). The allogenic nerve graft. In: Millesi, H., Schmidhammer, R. (eds) How to Improve the Results of Peripheral Nerve Surgery. Acta Neurochirurgica Supplementum, vol 100. Springer, Vienna. https://doi.org/10.1007/978-3-211-72958-8_9
Download citation
DOI: https://doi.org/10.1007/978-3-211-72958-8_9
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-72955-7
Online ISBN: 978-3-211-72958-8
eBook Packages: MedicineMedicine (R0)