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Cavernous sinus meningiomas

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Cavernous Sinus
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Abstract

Meningiomas look simple. Neurosurgeons have enjoyed great success in treating them, because the majority of meningiomas are readily accessible benign tumors and complete resection usually proves curative. Their simplicity evaporates when they recur, when they are attached to major draining sinuses, or when they are insinuated among critical neural structures. Such is the case with meningiomas involving the cavernous sinus (CSM). Within this compact space run the carotid artery and the ocular motor nerves, and nearby lie the optic nerve and pituitary body. As neurosurgeons pursue the goal of total resection, the risks to vision, ocular function, appearance, and stroke are ever-present.

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References

  1. Bozzetti C, Camisa R, Nizzoli R, Manotti L, Guazzi A, Naldi N, Mazza S, Nizzoli V, Cocconi G (1995) Estrogen and progesterone receptors in human meningiomas: biochemical and immunocytochemical evaluation. Surg Neurol 43: 230–233; discussion 234

    Article  PubMed  CAS  Google Scholar 

  2. Cusimano MD, Sekhar LN, Sen CN, Pomonis S, Wright DC, Biglan AW, Jannetta PJ (1995) The results of surgery for benign tumors of the cavernous sinus. Neurosurgery 37: 1–9; discussion 9–10

    Article  PubMed  CAS  Google Scholar 

  3. Custer BS, Koepsell TD, Mueller BA (2002) The association between breast carcinoma and meningioma in women. Cancer 94: 1626–1635

    Article  PubMed  CAS  Google Scholar 

  4. De Jesus O, Sekhar LN, Parikh HK, Wright DC, Wagner DP (1996) Long-term follow-up of patients with meningiomas involving the cavernous sinus: recurrence, progression, and quality of life. Neurosurgery 39: 915–919; discussion 919–920

    Article  PubMed  Google Scholar 

  5. DeMonte F, Smith HK, Al-Mefty O (1994) Outcome of aggressive removal of cavernous sinus meningiomas. J Neurosurg 81: 245–251

    Article  PubMed  CAS  Google Scholar 

  6. Dolenc VV (2003) Microsurgical anatomy and surgery of the central skull base. Springer, Wien New York, pp 162–177

    Google Scholar 

  7. Goodwin JW, Crowley J, Eyre HJ, Stafford B, Jaeckle KA, Townsend JJ (1993) A phase II evaluation of tamoxifen in unresectable or refractory meningiomas: a Southwest Oncology Group study. J Neurooncol 15: 75–77

    Article  PubMed  CAS  Google Scholar 

  8. Grunberg SM, Weiss MH, Spitz IM, Ahmadi J, Sadun A, Russell CA, Lucci L, Stevenson LL (1991) Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. J Neurosurg 74: 861–866

    Article  PubMed  CAS  Google Scholar 

  9. Harris FS, Rhoton AL (1976) Anatomy of the cavernous sinus. A microsurgical study. J Neurosurg 45: 169–180

    Article  PubMed  CAS  Google Scholar 

  10. Harrison MJ, Wolfe DE, Lau TS, Mitnick RJ, Sachdev VP (1991) Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature. J Neurosurg 75: 564–574

    Article  PubMed  CAS  Google Scholar 

  11. Jacobs DH, Holmes FF, McFarlane MJ (1992) Meningiomas are not significantly associated with breast cancer. Arch Neurol 49: 753–756

    PubMed  CAS  Google Scholar 

  12. Johnson MD, Powell SZ, Boyer PJ, Weil RJ, Moots PL (2002) Dural lesions mimicking meningiomas. Hum Pathol 33: 1211–1226

    Article  PubMed  Google Scholar 

  13. Kaba SE, DeMonte F, Bruner JM, Kyritsis AP, Jaeckle KA, Levin V, Yung WK (1997) The treatment of recurrent unresectable and malignant meningiomas with interferon alpha-2b. Neurosurgery 40: 271–275

    Article  PubMed  CAS  Google Scholar 

  14. Knosp E, Perneczky A, Koos WT, Fries G, Matula C (1996) Meningiomas of the space of the cavernous sinus. Neurosurgery 38: 434–442; discussion 442–444

    Article  PubMed  CAS  Google Scholar 

  15. Kuratsu J, Kochi M, Ushio Y (2000) Incidence and clinical features of asymptomatic meningiomas. J Neurosurg 92: 766–770

    Article  PubMed  CAS  Google Scholar 

  16. Lamberts SW, Tanghe HL, Avezaat CJ, Braakman R, Wijngaarde R, Koper JW, de Jong H (1992) Mifepristone (ru 486) treatment of meningiomas. J Neurol Neurosurg Psychiatry 55: 486–490

    Article  PubMed  CAS  Google Scholar 

  17. Leber KA, Bergloff J, Pendl G (1998) Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery. J Neurosurg 88: 43–50

    Article  PubMed  CAS  Google Scholar 

  18. Lee JY, Niranjan A, McInerney J, Kondziolka D, Flickinger JC, Lunsford LD (2002) Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas. J Neurosurg 97: 65–72

    Article  PubMed  Google Scholar 

  19. Mason WP, Gentili F, Macdonald DR, Hariharan S, Cruz CR, Abrey LE (2002) Stabilization of disease progression by hydroxyurea in patients with recurrent or unresectable meningioma. J Neurosurg 97: 341–346

    Article  PubMed  CAS  Google Scholar 

  20. Nathan H, Ouaknine G, Kosary IZ (1974) The abducens nerve. Anatomical variations in its course. J Neurosurg 41: 561–566

    Article  PubMed  CAS  Google Scholar 

  21. Newton HB, Slivka MA, Stevens C (2000) Hydroxyurea chemotherapy for unresectable or residual meningioma. J Neurooncol 49: 165–170

    Article  PubMed  CAS  Google Scholar 

  22. Nicolato A, Foroni R, Alessandrini F, Bricolo A, Gerosa M (2002) Radiosurgical treatment of cavernous sinus meningiomas: experience with 122 treated patients. Neurosurgery 51: 1153–1159; discussion 1159–1161

    Article  PubMed  Google Scholar 

  23. O’Sullivan MG, van Loveren HR, Tew JM Jr (1997) The surgical resectability of meningiomas of the cavernous sinus. Neurosurgery 40: 238–244; discussion 245–247

    Article  PubMed  Google Scholar 

  24. Olivero WC, Lister JR, Elwood PW (1995) The natural history and growth rate of asymptomatic meningiomas: a review of 60 patients. J Neurosurg 83: 222–224

    Article  PubMed  CAS  Google Scholar 

  25. Pamir MN, Kilic T, Bayrakli F, Peker S (2005) Changing treatment strategy of cavernous sinus meningiomas: experience of a single institution. Surg Neurol 64[Suppl 2]: S58–S66

    Article  PubMed  Google Scholar 

  26. Parkinson D, West M (1990) Lesions of the cavernous plexus region. In: Youmans JR (ed) Neurological surgery. W.B. Saunders, Philadelphia, pp 3351–3370

    Google Scholar 

  27. Pendl G, Schrottner O, Eustacchio S, Ganz JC, Feichtinger K (1998) Cavernous sinus meningiomas–what is the strategy: upfront or adjuvant gamma knife surgery? Stereotact Funct Neurosurg 70[Suppl 1]: 33–40

    Article  PubMed  Google Scholar 

  28. Piper JG, Follett KA, Fantin A (1994) Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant. Neurosurgery 34: 723–725; discussion 725

    Article  PubMed  CAS  Google Scholar 

  29. Pollock BE, Stafford SL (2005) Results of stereotactic radiosurgery for patients with imaging defined cavernous sinus meningiomas. Int J Radiat Oncol Biol Phys 62: 1427–1431

    PubMed  Google Scholar 

  30. Ron E, Modan B, Boice JD Jr, Alfandary E, Stovall M, Chetrit A, Katz L (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319: 1033–1039

    PubMed  CAS  Google Scholar 

  31. Schlehofer B, Blettner M, Wahrendorf J (1992) Association between brain tumors and menopausal status. J Nat Cancer Inst 84: 1346–1349

    Article  PubMed  CAS  Google Scholar 

  32. Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies of other sites. The unique association between meningiomas and breast cancer. Neurology 25: 705–712

    PubMed  CAS  Google Scholar 

  33. Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neuro-Oncol 1: 14–25

    PubMed  CAS  Google Scholar 

  34. Tagle P, Villanueva P, Torrealba G, Huete I (2002) Intracranial metastasis or meningioma? An uncommon clinical diagnostic dilemma. Surg Neurol 58: 241–245

    Article  PubMed  Google Scholar 

  35. Van Havenbergh T, Carvalho G, Tatagiba M, Plets C, Samii M (2003) Natural history of petroclival meningiomas. Neurosurgery 52: 55–62; discussion 62–54

    Article  PubMed  Google Scholar 

  36. Wascher TM, Spetzler RF, Zabramski JM (1993) Improved transdural exposure and temporary occlusion of the petrous internal carotid artery for cavernous sinus surgery. Technical note. J Neurosurg 78: 834–837

    Article  PubMed  CAS  Google Scholar 

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Al-Mefty, O., Heth, J.A. (2009). Cavernous sinus meningiomas. In: Dolenc, V.V., Rogers, L. (eds) Cavernous Sinus. Springer, Vienna. https://doi.org/10.1007/978-3-211-72138-4_11

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  • DOI: https://doi.org/10.1007/978-3-211-72138-4_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-72137-7

  • Online ISBN: 978-3-211-72138-4

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