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Tumor hypoxia and therapeutic resistance

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Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

Abstract

For many years, the identification of tumor hypoxia, its systematic characterization and the assessment of its clinical relevance were not possible due to the lack of methods suitable for the routine measurement of intratumoral oxygen tensions in patients. In the late 1980s, a novel and clinically applicable standardized procedure was established enabling the determination of tumor oxygenation in accessible primary tumors, local recurrences, and metastatic lesions in patients using a computerized polarographic needle electrode system (Höckel et al. 1991; Vaupel et al. 1991).Within a relatively short period of time, the significance of tumor oxygenation for therapy outcome became evident in numerous experimental and clinical studies (for a review see Vaupel and Kelleher 1999).

Supported by a grant from the Deutsche Krebshilfe (106758).

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099, Mainz, Germany

    Prof. Dr. Peter Vaupel

  2. Department of Obstetrics and Gynecology, University of Leipzig, Philipp-Rosenthal-Strasse 55, 04103, Leipzig, Germany

    Prof. Dr. Michael Höckel

Authors
  1. Prof. Dr. Peter Vaupel
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  2. Prof. Dr. Michael Höckel
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Correspondence to Peter Vaupel or Michael Höckel .

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Editors and Affiliations

  1. Department of Internal Medicine (Cancer Research), West German Cancer Center, University Hospital of Essen, Essen, Germany

    Mohammad Resa Nowrousian

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Vaupel, P., Höckel, M. (2008). Tumor hypoxia and therapeutic resistance. In: Nowrousian, M.R. (eds) Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology. Springer, Vienna. https://doi.org/10.1007/978-3-211-69459-6_11

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  • DOI: https://doi.org/10.1007/978-3-211-69459-6_11

  • Publisher Name: Springer, Vienna

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