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Wundheilung und Immunologie: Einfluss von immunsuppressiver Therapie

  • Chapter
Manual der Wundheilung

Zusammenfassung

Die Wundheilung ist ein komplexer Vorgang, bei welchem nicht nur verschiedenste Matrixproteine sondern auch eine Reihe von Zellen miteinander interagieren müssen. Die Wundheilung läuft in verschiedenen Phasen ab, die sich überlappen und deren Steuerung von einer Reihe von Mediatoren und Wachstumsfaktoren abhängig ist. Die Phasen der Wundheilung gliedern sich in eine Entzündungsphase, in eine Proliferationsphase und in eine Phase der Gewebsumbildung (tissue remodelling). Wundheilungsstörungen, als chronisch nicht heilende Wunden, treten bei immunsupprimierten Patienten in der Onkologie, bei Sepsis und Stoffwechselerkrankungen wie Diabetes mellitus oder nach Organtransplantationen auf. Medikamente wie Kortikosteroide, nichtsteroidale Antiphlogistika, Calzineurininhibitoren wie Tacrolimus und andere Immsunsuppressiva wie Myophenolatmofetil können in die Wundheilung eingreifen und zu Wundheilungsstörungen führen.

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Authors and Affiliations

  1. Univ.-Klinik für Dermatologie und Venerologie, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck

    Ao. Univ.-Prof. Dr. N. Sepp

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  1. Ao. Univ.-Prof. Dr. N. Sepp
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Editors and Affiliations

  1. Universitätsklinik für Chirurgie, Medizinische Universität Wien, Wien, Österreich

    Thomas Wild

  2. Abteilung für Dermatologie und Venerologie, AKH Linz, Linz, Österreich

    Josef Auböck

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Sepp, N. (2007). Wundheilung und Immunologie: Einfluss von immunsuppressiver Therapie. In: Wild, T., Auböck, J. (eds) Manual der Wundheilung. Springer, Vienna. https://doi.org/10.1007/978-3-211-69454-1_24

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  • DOI: https://doi.org/10.1007/978-3-211-69454-1_24

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-25212-3

  • Online ISBN: 978-3-211-69454-1

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