Skip to main content
SpringerLink
Log in

Cardiovascular aspects of Parkinson disease

  • Conference paper
Parkinson’s Disease and Related Disorders

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURALTRANS,volume 70))

Summary

This chapter provides an update about cardiovascular aspects of Parkinson disease (PD), with the following topics: (1) Orthostatic hypotension (OH) as an early finding in PD; (2) neurocirculatory abnormalities in PD+OH independent of levodopa treatment; (3) cardiac and extracardiac noradrenergic denervation in PD+OH; (4) progressive loss of cardiac sympathetic innervation in PD without OH.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allcock LM, Ullyart K, Kenny RA, Burn DJ (2004) Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry 75:1470–1471

    Article  PubMed  CAS  Google Scholar 

  • Amino T, Orimo S, Takahashi A, Uchihara T, Mizusawa H (2005) Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Path 15: 29–34

    Article  Google Scholar 

  • Briebach T, Baas H, Fischer PA (1990) Orthostatic dysregulation in Parkinson syndrome. Results of a study of 250 patients. Nervenarzt 61: 491–494

    PubMed  CAS  Google Scholar 

  • Goldstein DS (2005) Orthostatic hypotension as an early finding in Parkinson disease. Clin Auton Res (in press)

    Google Scholar 

  • Goldstein DS, Holmes C, Dendi R, Bruce S, Li S-T (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58:1247–1255

    PubMed  CAS  Google Scholar 

  • Goldstein DS, Holmes C, Li ST, Bruce S, Metman LV, Cannon RO (2000) Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 133:338–347

    PubMed  CAS  Google Scholar 

  • Goldstein DS, Eldadah BA, Holmes C, Pechnik S, Moak J, Saleem A, Sharabi Y (2005) Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension. Independence from levodopa treatment. Hypertension 46: 1–7

    Article  CAS  Google Scholar 

  • Kaufmann H, Nahm K, Purohit D, Wolfe D (2004) Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 63: 1093–1095

    PubMed  Google Scholar 

  • Korchounov A, Kessler KR, Schipper HI (2004) Differential effects of various treatment combinations on cardiovascular dysfunction in patients with Parkinson’s disease. Acta Neurol Scand 109: 45–51

    Article  PubMed  CAS  Google Scholar 

  • Li ST, Dendi R, Holmes C, Goldstein DS (2002) Progressive loss of cardiac sympathetic innervation in Parkinson’s disease. Ann Neurol 52: 220–223

    Article  PubMed  Google Scholar 

  • Magalhaes M, Wenning GK, Daniel SE, Quinn NP (1995) Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson’s disease — a retrospective comparison. Acta Neurol Scand 91: 98–102

    Article  PubMed  CAS  Google Scholar 

  • Nylin G, Levander M (1948) Studies on the circulation with the aid of tagged erythrocytes in a case of orthostatic hypotension (asympathicotonic hypotension). Ann Intern Med 28: 723–746

    PubMed  CAS  Google Scholar 

  • Orimo S, Ozawa E, Oka T, Nakade S, Tsuchiya K, Yoshimoto M, Wakabayashi K, Takahashi H (2001) Different histopathology accounting for a decrease in myocardial MIBG uptake in PD and MSA. Neurology 57: 1140–1141

    PubMed  CAS  Google Scholar 

  • Orimo S, Oka T, Miura H, Tsuchiya K, Mori F, Wakabayashi K, Nagao T, Yokochi M (2002) Sympathetic cardiac denervation in Parkinson’s disease and pure autonomic failure but not in multiple system atrophy. J Neurol Neurosurg Psychiatry 73: 776–777

    Article  PubMed  CAS  Google Scholar 

  • Schober R, Langston JW, Forno LS (1975) Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases. Eur Neurol 13: 177–188

    PubMed  CAS  Google Scholar 

  • Senard JM, Rai S, Lapeyre-Mestre M, Brefel C, Rascol O, Rascol A, Montastruc JL (1997) Prevalence of orthostatic hypotension in Parkinson’s disease. J Neurol Neurosurg Psychiatry 63: 584–589

    Article  PubMed  CAS  Google Scholar 

  • Tipre DN, Goldstein DS (2005) Cardiac and extracardiac sympathetic denervation in Parkinson disease with orthostatic hypotension and in pure autonomic failure. J Nucl Med 46: 1775–1781

    PubMed  CAS  Google Scholar 

  • Vanderhaeghen JJ, Perier O, Sternon JE (1970) Pathological findings in idiopathic orthostatic hypotension. Its relationship with Parkinson’s disease. Arch Neurol 22: 207–214

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, Bethesda, MD, 20892-1620, USA

    D. S. Goldstein MD, PhD

Authors
  1. D. S. Goldstein MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik fĂĽr Psychiatrie und Psychotherapie, WĂĽrzburg, Germany

    P. Riederer  & M. Gerlach  & 

  2. Universitätsklinikum der TU Dresden, Dresden, Germany

    H. Reichmann

  3. Israel Institute of Technology, Haifa, Israel

    M. B. H. Youdim

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag

About this paper

Cite this paper

Goldstein, D.S. (2006). Cardiovascular aspects of Parkinson disease. In: Riederer, P., Reichmann, H., Youdim, M.B.H., Gerlach, M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna . https://doi.org/10.1007/978-3-211-45295-0_51

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-45295-0_51

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-28927-3

  • Online ISBN: 978-3-211-45295-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation