Summary
Zebrafish have become an important model organism to study the genetic control of vertebrate nervous system development. Here, we present an overview on the formation of dopaminergic neuronal groups in zebrafish and compare the positions of DA neurons in fish and mammals using the neuromere model of the vertebrate brain. Based on mutant analysis, we evaluate the role of several signaling pathways in catecholaminergic neuron specification. We further discuss the prospect of identifying novel genes involved in dopaminergic development through forward genetics mutagenesis screens.
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References
Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A (1999) Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol 208: 473–487
Holzschuh J, Barrallo-Gimeno A, Ettl AK, Durr K, Knapik EW, Driever W (2003a) Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Development 130: 5741–5754
Holzschuh J, Hauptmann G, Driever W (2003b) Genetic analysis of the roles of Hh, FGF8, and nodal signaling during catecholaminergic system development in the zebrafish brain. J Neurosci 23: 5507–5519
Holzschuh J, Ryu S, Aberger F, Driever W (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mech Dev 101: 237–243
Kaslin J, Panula P (2001) Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio). J Comp Neurol 440: 342–377
Puelles L, Verney C (1998) Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos. J Comp Neurol 394: 283–308
Rink E, Wullimann MF (2000) The teleostean (zebra-fish) dopamine system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Research Interactive Year 2000: 1–15
Rink E, Wullimann MF (2002) Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study. Brain Res Dev Brain Res 137: 89–100
Smeets WJ, Gonzalez A (2000) Catecholamine systems in the brain of vertebrates: new perspectives through a comparative approach. Brain Res Brain Res Rev 33: 308–379
Smeets WJ, Marin O, Gonzalez A (2000) Evolution of the basal ganglia: new perspectives through a comparative approach. J Anat 196 (Pt 4): 501–517
Ye W, Shimamura K, Rubenstein JLR, Hynes MA, Rosenthal A (1998) FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93: 755–766
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© 2006 Springer-Verlag
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Ryu, S., Holzschuh, J., Mahler, J., Driever, W. (2006). Genetic analysis of dopaminergic system development in zebrafish. In: Riederer, P., Reichmann, H., Youdim, M.B.H., Gerlach, M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna . https://doi.org/10.1007/978-3-211-45295-0_11
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DOI: https://doi.org/10.1007/978-3-211-45295-0_11
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-28927-3
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