Abstract
Microsystem technologies offer significant advantages in the development of neural prostheses. In the last two decades, it has become feasible to develop intelligent prostheses that are fully implantable into the human body with respect to functionality, complexity, size, weight, and compactness. Design and development enforce collaboration of various disciplines including physicians, engineers, and scientists. The retina implant system can be taken as one sophisticated example of a prosthesis which bypasses neural defects and enables direct electrical stimulation of nerve cells. This micro implantable visual prosthesis assists blind patients to return to the normal course of life. The retina implant is intended for patients suffering from retinitis pigmentosa or macular degeneration.
In this contribution, we focus on the epiretinal prosthesis and discuss topics like system design, data and power transfer, fabrication, packaging and testing. In detail, the system is based upon an implantable micro electro stimulator which is powered and controlled via a wireless inductive link. Microelectronic circuits for data encoding and stimulation are assembled on flexible substrates with an integrated electrode array. The implant system is encapsulated using parylene C and silicone rubber. Results extracted from experiments in vivo demonstrate the retinotopic activation of the visual cortex.
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Chow AY, Pardue MT, Perlman JI, Ball SL, Chow VY, Hetling JR, Peyman GA, Liang C, Stubbs EB Jr, Peachey NS (2002) Subretinal implantation of semiconductor-based photodiodes: durability of novel implant designs. J Rehabil Res Dev 39: 313–321
Eckmiller R (1997) Learning retina implants with epiretinal contacts. Ophthalmic Res 29: 281–289
Grinvald A, Shoham D, Shmuel A, Glaser DE, Vanzetta I, Shtoyerman E, Slovin H, Wijnbergen C, Hildesheim R, Sterkin A, Arieli A (1999) In-vivo optical imaging of cortical architecture and dynamics. In: Windhorst U, Johansson H (eds) Modern techniques in neuroscience research. Springer, Berlin Heidelberg, pp 893–969
Dawson WW, Radtke ND (1977) The electrical stimulation of the retina by indwelling electrodes. Invest Ophthalmol Vis Sci 16: 249–252
Hartline HK, Wagner HG, MacNichol Efjr (1952) The peripheral origin of nervous activity in the visual system. Cold Spr Harb Symp quant Biol 17: 125–141
Humayun MS, de Juan E Jr, Weiland JD, Dagnelie G, Katona S, Greenberg R, Suzuki S (1999) Pattern electrical stimulation of the human retina. Vision Res 39: 2569–2576
Hünermann R, Eckmiller R (1998) Implementation of tunable receptive field (RF) filters for learning retina implants. In: Niklasson LF, Bodén MB, Ziemke TB (eds) Proc of ICANN’98, Skövde. Springer, Berlin Heidelberg New York, pp 887–892
Krisch I, Görtz M, Trieu H-K, Mokwa W, Hosticka B-J (2003) Development and functional test of an epiretinal prosthesis. Applications — trends — visions. Proc of 2nd VDE World Microtechnologies Congress, October 13–15, 2003, International Congress Centre, Munich, Germany. VDE Verlag, Berlin, pp 233–238
Meyer JU, Stieglitz T, Scholz O, Haberer W, Beutel H (2001) High density interconnects and flexible hybrid assemblies for active biomedical implants. IEEE Trans Adv Pack 24: 366–374
Mokwa W (2004) MEMs Technologies for epiretinal stimulation of the retina. J Micromech Microeng 14: S12–S16
Schanze T, Wilms M, Eger M, Hesse L, Eckhorn R (2002) Activation zones in cat visual cortex evoked by electrical retina stimulation. Graefes Arch Clin Exp Ophthalmol 240: 947–954
Schwarz M, Hauschild R, Hosticka BJ, Huppertz J, Kneip T, Kolnsberg S, Ewe L, Trieu HK (2000) Single chip CMOS imagers and flexible microelectronic stimulators for a retina implant system. Sens Actuators 83: 40–46
Slavcheva E, Ewe L, Schnakenberg U, Mokwa W (2002) Electrochemical characterisation of different biocompatible metallic materials as planar and 3D-electrodes in neural stimulation microarrays. Proc 2nd European Medical & Biological Engineering Conference, Vienna, pp 784–785
Stieglitz T, Beutel H, Schuettler M, Meyer JU (2000) Micromachined, polyimide-based devices for flexible neural interfaces. Biomed Microdev 2: 283–294
Stieglitz T, Beutel H, Keller R, Blau C, Meyer JU (1997) Development of flexible stimulation devices for a retina implant system. Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp 2307–2310
Stieglitz T (2004) Considerations on surface and structural biocompatibility as prerequisite for long-term stability of neural prostheses. J Nanosci Nanotech 4: 496–503
Walter P, Szurman P, Vobig M, Berk H, Luedtke-Handjery HC, Richter H, Mittermayer C, Heimann K, Sellhaus B (1999) Successful long-term implantation of electrically inactive epiretinal microelectrode arrays in rabbits. Retina 19: 546–552
Walter P, Kisvárday ZF, Görtz M, Alteheld N, Rössler G, Stieglitz T, Eysel UT (2005) Cortical activation with a completely implanted wireless retinal prosthesis. Invest Ophthalmol Vis Sci 46: 1780–1785
World Health Organisation (2005) Blindness and visual disability: other leading causes worldwide. Retrieved from http://www.who.int/mediacentre/factsheets/fs282/en/index.html
Zrenner E, Gekeler F, Gabel VP, Graf HG, Graf M, Guenther E, Haemmerle H, Hoefflinger B, Kobuch K, Kohler K, Nisch W, Sachs H, Schlosshauer B, Schubert M, Schwahn H, Stelle M, Stett A, Troeger B, Weiss S (2001) Subretinal microphotodiode array as replacement for degenerated photoreceptors? Ophthalmologe 98: 357–363
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Krisch, I., Hosticka, B.J. (2007). Restoring visual perception using microsystem technologies: engineering and manufacturing perspectives. In: Sakas, D.E., Simpson, B.A. (eds) Operative Neuromodulation. Acta Neurochirurgica Supplements, vol 97/2. Springer, Vienna. https://doi.org/10.1007/978-3-211-33081-4_54
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DOI: https://doi.org/10.1007/978-3-211-33081-4_54
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