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Leptin plays a role in ruptured human brain arteriovenous malformations

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Cerebral Hemorrhage

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 105))

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References

  1. Choi JH, Mohr JP (2005) Brain arteriovenous malformations in adults. Lancet Neurol 4: 299–308

    Article  PubMed  Google Scholar 

  2. Fruhbeck G (2006) Intracellular signaling pathways activated by leptin. Biochem J 393: 7–20

    Article  PubMed  CAS  Google Scholar 

  3. Gault J, Sarin H, Awadallah NA, Shenkar R, Awad IA (2004) Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance. Neurosurgery 55: 1–17

    Article  PubMed  Google Scholar 

  4. Mütze J, Roth J, Gerstberger R, Matsumura K, Hübschle T (2006) Immunohistochemical evidence of functional leptin receptor expression in neuronal and endothelial cells of the rat brain. Neurosci Lett 394: 105–110

    Article  PubMed  CAS  Google Scholar 

  5. Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33: 95–102

    PubMed  CAS  Google Scholar 

  6. Sato S, Kodama N, Sasaki T, Matsumoto M, Ishikawa T (2004) Perinidal dilated capillary networks in cerebral arteriovenous malformations. Neurosurgery 54: 163–170

    Article  PubMed  Google Scholar 

  7. Schäfer K, Halle M, Goeschen C, Dellas C, Pynn M, Loskutoff DJ, Konstantinides S (2004) Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc Biol 24: 112–117

    Article  PubMed  CAS  Google Scholar 

  8. Söderberg S, Ahrén B, Stegmayr B, Johnson O, Wiklund PG, Weinehall L, Hallmans G, Olsson T (1999) Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke 30: 328–337

    PubMed  Google Scholar 

  9. Spetzler RF, Martin NA (1986) A proposed grading system for arteriovenous malformations. J Neurosurg 65: 476–483

    Article  PubMed  CAS  Google Scholar 

  10. Werner N, Nickenig G (2004) From fat fighter to risk factor: the zigzag trek of leptin. Arterioscler Thromb Vasc Biol 24: 7–9

    Article  PubMed  CAS  Google Scholar 

  11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China

    Q. Xie, X. C. Chen, Y. Gong & Y. X. Gu

Authors
  1. Q. Xie
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  2. X. C. Chen
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  3. Y. Gong
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  4. Y. X. Gu
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Huashan Hospital, Fudan University, Shanghai, China

    Liang-Fu Zhou , Xian-Cheng Chen  & Feng-Ping Huang ,  & 

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Guohua Xi , Richard F. Keep , Ya Hua  & Karin Muraszko , ,  & 

  3. Department of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China

    Yi-Cheng Lu

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© 2008 Springer-Verlag

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Xie, Q., Chen, X.C., Gong, Y., Gu, Y.X. (2008). Leptin plays a role in ruptured human brain arteriovenous malformations. In: Zhou, LF., et al. Cerebral Hemorrhage. Acta Neurochirurgica Supplementum, vol 105. Springer, Vienna. https://doi.org/10.1007/978-3-211-09469-3_42

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  • DOI: https://doi.org/10.1007/978-3-211-09469-3_42

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-09468-6

  • Online ISBN: 978-3-211-09469-3

  • eBook Packages: MedicineMedicine (R0)

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