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Development of a cerebral microvascular dysplasia model in rodents

  • Conference paper
Cerebral Hemorrhage

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 105))

Abstract

Normal vasculature development of the central nervous system is extremely important because patients with vascular malformations are at life-threatening risk for intracranial hemorrhage or cerebral ischemia. The etiology and pathogenesis of abnormal vasculature development in the central nervous system are unknown, and progress is hampered by the lack of animal models for human cerebrovascular diseases. Here, we report our current study on cerebral microvascular dysplasia (CMVD) development. Using vascular endothelial growth factor hyper-stimulation, we demonstrated that aberrant microvessels could be developed in the rodent brain under certain conditions (such as genetic deficient background, local cytokine and chemokine release, or exogenous vessel dilating stimulation) that may speed up focal angiogenesis and lead to cerebral vascular dysplasia.

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Author information

Authors and Affiliations

  1. Center for Cerebrovascular Research, UCSF Department of Anesthesia and Perioperative Care, University of California, 1001 Potrero Avenue, Rm. 3C-38, San Francisco, CA, 94110, USA

    H. Su, Q. Hao, F. Shen, Y. Zhu, C. Z. Lee, W. L. Young & G. Y. Yang MD, PhD

  2. Department of Neurological Surgery, University of California, San Francisco, CA, USA

    W. L. Young & G. Y. Yang MD, PhD

  3. Department of Neurology, University of California, San Francisco, CA, USA

    W. L. Young

Authors
  1. H. Su
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  2. Q. Hao
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  3. F. Shen
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  4. Y. Zhu
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  5. C. Z. Lee
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  6. W. L. Young
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  7. G. Y. Yang MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Huashan Hospital, Fudan University, Shanghai, China

    Liang-Fu Zhou , Xian-Cheng Chen  & Feng-Ping Huang ,  & 

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Guohua Xi , Richard F. Keep , Ya Hua  & Karin Muraszko , ,  & 

  3. Department of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China

    Yi-Cheng Lu

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© 2008 Springer-Verlag

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Su, H. et al. (2008). Development of a cerebral microvascular dysplasia model in rodents. In: Zhou, LF., et al. Cerebral Hemorrhage. Acta Neurochirurgica Supplementum, vol 105. Springer, Vienna. https://doi.org/10.1007/978-3-211-09469-3_36

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  • DOI: https://doi.org/10.1007/978-3-211-09469-3_36

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-09468-6

  • Online ISBN: 978-3-211-09469-3

  • eBook Packages: MedicineMedicine (R0)

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