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Cerebral Hemorrhage pp 99–100Cite as

Long-term effects of melatonin after intracerebral hemorrhage in rats

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Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 105))

Abstract

Free radical scavengers have been shown to improve short-term outcome after intracerebral hemorrhage (ICH). The purpose of this study was to evaluate whether melatonin (a potent free radical scavenger and an indirect antioxidant) can improve short- and=or long-term neurological function after ICH, which was induced by collagenase injection into the striatum of adult rats. Melatonin (15mg/kg) was administered by intra-peritoneal injection at 1, 24, 48, and 72h. Neurological and behavioral testing was performed at several time points from 1 day to 8 weeks post-ICH. Neurological and behavioral deficits were observed in ICH rats at all time points, but the melatonin treatment regimen did not improve performance or level of brain injury.

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Author information

Authors and Affiliations

  1. Department of Psychology, Loma Linda University, 11130 Anderson St. 119, Loma Linda, CA, 92354, USA

    R. E. Hartman Ph.D

  2. Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA

    H. A. Rojas, T. Lekic, R. Ayer, S. Lee, V. Jadhav, E. Titova & J. Tang

  3. Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA

    J. H. Zhang

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  1. R. E. Hartman Ph.D
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  2. H. A. Rojas
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  3. T. Lekic
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  4. R. Ayer
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  5. S. Lee
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  6. V. Jadhav
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  7. E. Titova
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  8. J. Tang
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  9. J. H. Zhang
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Huashan Hospital, Fudan University, Shanghai, China

    Liang-Fu Zhou , Xian-Cheng Chen  & Feng-Ping Huang ,  & 

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Guohua Xi , Richard F. Keep , Ya Hua  & Karin Muraszko , ,  & 

  3. Department of Neurosurgery, Shanghai Changzheng Hospital, Shanghai, China

    Yi-Cheng Lu

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© 2008 Springer-Verlag

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Cite this paper

Hartman, R.E. et al. (2008). Long-term effects of melatonin after intracerebral hemorrhage in rats. In: Zhou, LF., et al. Cerebral Hemorrhage. Acta Neurochirurgica Supplementum, vol 105. Springer, Vienna. https://doi.org/10.1007/978-3-211-09469-3_20

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  • DOI: https://doi.org/10.1007/978-3-211-09469-3_20

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-09468-6

  • Online ISBN: 978-3-211-09469-3

  • eBook Packages: MedicineMedicine (R0)

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