Summary
Inspection of the structural models of five refined crystal structures of different unliganded and liganded forms of mitochondrial aspartate aminotransferase (McPhalen et al.P this Volume) has led to a number of observations about ligand binding and conformational changes involving both the “small domain” and the coenzyme that are relevant to the catalytic mechanism of this enzyme.
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Jansonius, J.N., Vincent, M.G., McPhalen, C.A., Picot, D. (1987). Spatial Aspects of Catalysis by Mitochondrial Aspartate Aminotransferase. In: Korpela, T.K., Christen, P. (eds) Biochemistry of Vitamin B6 . Birkhäuser Congress Reports. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-9308-4_16
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DOI: https://doi.org/10.1007/978-3-0348-9308-4_16
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