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The nature and development of steroid hormone receptors

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Development of Hormone Receptors

Part of the book series: EXS 53: Experientia Supplementum ((EXS,volume 53))

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Abstract

Our current conceptualization of the primary steps in steroid hormone (estrogens, androgens, progestins and corticoids) action is shown in figure l10. We now believe that the steroids, which are generally hydrophobic molecules, diffuse through the outer cell membrane and cytoplasm to the nucleus47. In the nucleus the steroids bind to their respective receptors which are assumed to be bound with low affinity to some nuclear component35. This nuclear component could be DNA, nuclear matrix or some chromatin protein (acceptor) but this has not been proven conclusively. As a result of the steroid-receptor interaction, the receptor’s conformation changes dramatically and its affinity for nuclear components becomes much higher1113,51. This change in the association of receptor with nuclear components is correlated with, and may lead to the rapid (within minutes) changes in gene expression observed in the target tissues1,25,29. This general model may apply to all the steroid hormones, vitamin D metabolites and thyroxine, but has not been clearly demonstrated for all such hormones.

Supported in part by the College of Agricultural and Life Sciences, University of Wisconsin, Madison; NIH Grants HD 08192, CA18110, 5T32HD07259 and National Foundation for Cancer Research.

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Authors and Affiliations

  1. Departments of Biochemistry and Animal Sciences, University of Wisconsin, 53706, Madison, Wisconsin, USA

    J. Gorski

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  1. Semmelweis University of Medicine, Budapest, Hungary

    György Csaba

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© 1987 Birkhäuser Verlag

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Gorski, J. (1987). The nature and development of steroid hormone receptors. In: Csaba, G. (eds) Development of Hormone Receptors. EXS 53: Experientia Supplementum, vol 53. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9291-9_5

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  • DOI: https://doi.org/10.1007/978-3-0348-9291-9_5

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9982-6

  • Online ISBN: 978-3-0348-9291-9

  • eBook Packages: Springer Book Archive

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