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Internalization of polypeptide hormones and receptor recycling

  • Chapter
Development of Hormone Receptors

Part of the book series: EXS 53: Experientia Supplementum ((EXS,volume 53))

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Abstract

The insulin receptor is an integral plasma membrane glycoprotein of most cells. It consists of 2 subunits linked by disulfide bonds; the alpha and beta subunits of the receptor are synthesized by way of a single chain proreceptor which is cleaved and further processed, by the addition of complex carbohydrates, prior to insertion into the plasma membrane49. Recently a cDNA encoding the proreceptor has been cloned and the protein sequence of the receptor elucidated29,85. The alpha subunit of the receptor is the major binding component and the beta subunit is a tyrosine specific protein kinase which itself can be autophosphorylated.

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Authors and Affiliations

  1. Institute of Histology and Embryology, University of Geneva Medical Center, CH-1211, Geneva 4, Switzerland

    J.-L Carpentier, A. Robert & L. Orci

  2. Diabetes Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA

    P. Gorden

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  1. J.-L Carpentier
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  2. P. Gorden
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  3. A. Robert
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  1. Semmelweis University of Medicine, Budapest, Hungary

    György Csaba

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Carpentier, JL., Gorden, P., Robert, A., Orci, L. (1987). Internalization of polypeptide hormones and receptor recycling. In: Csaba, G. (eds) Development of Hormone Receptors. EXS 53: Experientia Supplementum, vol 53. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9291-9_4

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