Skip to main content
SpringerLink
Log in

Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man

  • Chapter
Development of Hormone Receptors

Part of the book series: EXS 53: Experientia Supplementum ((EXS,volume 53))

Abstract

Our focus is on the evolutionary origins of receptors for vertebrate hormones, neuroactive peptides, and related messengers. The first part will survey the possible evolutionary origins and phylogenetic distribution of the vertebrate-type messenger peptides providing a possible clue or guide to the same speculation for the receptor. Also, we will explain current data which suggest why receptors might need to be at least as old or as widely distributed as the messengers. In the latter part we will survey examples of materials in microbes that resemble vertebrate-type receptors and also highlight some possible applications to an understanding of human disease problems.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Acevedo, M. F., Slifkin, M., Pouchet, G. R., and Pardo, M., Immunocytochemical localization of a choriogonadotropin like protein in bacteria isolated from cancer patients. Cancer 41 (1978) 1217–1219.

    Article  Google Scholar 

  2. Berelowitz, M., LeRoith, D., Von Schenk, H., Newgard, C., Szabo, M., Frohman, L. A., Shiloach, J., and Roth, J., Somatostatin-like immunoactivity and biological activity is present in T. pyriformis, a ciliated Protozoan. Endocrinology 110 (1982) 1939–1944.

    Article  Google Scholar 

  3. Bhatnagar, Y. M., and Carraway, R., Bacterial peptides with C-terminal similarities to bovine neurotensin. Peptides 2 (1981) 51–59.

    Article  Google Scholar 

  4. Burshell, A., Stathis, P. A., Do, Y., Miller, S.C., and Feldman, D., Characterization of an estrogen-binding protein in the yeast Saccharomyces cerevisiae. J. biol. Chem. 259 (1984) 3450–3456.

    Google Scholar 

  5. Csaba, G., The present state in the phylogeny and ontogeny of hormone receptors. Horm. Metab. Res. 16 (1984). 329–335.

    Article  Google Scholar 

  6. Deftos, L., LeRoith, D., Shiloach, J., and Roth, J., Salmon calcitoninlike immunoactivity in extracts of Tetrahymena pyriformis. Horm. Metab. Res. 17 (1985) 82–85.

    Article  Google Scholar 

  7. Duve, H., and Thorpe, A., Immunofluorescent localization of insulin-like material in the median neurosecretory cells of the blowfly Calliphora vomitoria (Diptera). Cell Tissue Res. 200 (1979) 187–191.

    Article  Google Scholar 

  8. Duve, H., Thorpe, A., and Lazarus, N. R., Isolation of material displaying insulin-like immunological and biological activity from the brain of the blowfly, Calliphora vomitoria. Biochem. J. 184 (1979) 221–227.

    Google Scholar 

  9. Ebina, Y., Ellis, L., Jarnagin, K., Edery, M., Graf, L., Clauser, E., Ou, J.-H., Maslarz, F., Kan, Y.W., Goldfine, I.D., Roth, R. A., and Rutter, W.J., The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling. Cell 40 (1985) 747–758.

    Article  Google Scholar 

  10. Fukushima, J., Wanatabe, S., and Kaushima, K., Extraction and purification of substance with luteinizing hormone releasing activity from the leaves of avenasativa. Tohuku J. expl Med. 119 (1976) 115–122.

    Article  Google Scholar 

  11. Hargrave, P., Progress in Retinal Research, vol. 1, pp. 1–40, 1982.

    Article  Google Scholar 

  12. Heyma, P., Harrison, L., and Robins-Browne, R., submitted (1986).

    Google Scholar 

  13. Horgen, P. A., The role of the steroid sex pheromone antheridiol in controlling the development of male sex organs in the water mold, Achlya, in: Sexual Interactions in Eukaryotic Microbes, pp. 155–178. Eds D.H. O’Day and P. A. Horgen. Academic Press, New York 1981.

    Google Scholar 

  14. Hunt, L. T., and Dayoff, M. D., Structural and functional similarities among hormones and active peptides from distantly related eukaryotes, in: Peptides: Structure and Biological Function. Proceedings of the Sixth American Peptide Symposium, pp. 757–760. Eds E. Gross and J. Meienhofer. Pierce Chemical Co. Rockford, Illinois 1979.

    Google Scholar 

  15. Jackson, I. M. D., Abundance of immunoreactive thyrotropin-releasing hormone-like material in the alfalfa plant. Endocrinology 108 (1981) 344–346.

    Article  Google Scholar 

  16. Jenness, D.D., Burkholder, A.C., and Hartwell, L. H., Binding of a-factor pheromone to yeast cells: Chemical and genetic evidence for an α-factor receptor. Cell 35 (1983) 521–529.

    Article  Google Scholar 

  17. Josefsson, J.O., and Johansson, P., Naloxone-reversible effects of opioids on pinocytosis in amoebe proteus. Nature 282 (1979) 78–80.

    Article  Google Scholar 

  18. Josefsson, J.O., and Johansson, P., Naloxone-reversible effects of opioids on pinocytosis in amoebe proteus. Nature 282 (1979) 78–80.

    Article  Google Scholar 

  19. Krisher, K., and Cunningham, M.W., Myosin: A link between Streptococci and heart. Science 227 (1985) 413–415.

    Article  Google Scholar 

  20. LeRoith, D., Berelowitz, M., Pickens, W., Crosby, L. K., and Shiloach, J., Somatostatin-releated material in E.coli: Evidence for two molecular forms. Biochim. biophys. Acta 838 (1985) 355–340.

    Google Scholar 

  21. LeRoith, D., Lesniak, M.A., and Roth, J., Insulin in insects and annelids. Diabetes 30 (1981) 70–76.

    Article  Google Scholar 

  22. LeRoith, D., Liotta, A.S., Roth, J., Shiloach, J., Lewis, M.E., Pert, C.B., and Krieger, D.T., Corticotropin and β endorphin-like materials are native to unicellular organisms. Proc. natn. Acad. Sci. USA 79 (1982) 2086–2090.

    Article  Google Scholar 

  23. LeRoith, D., Pickens, W., Wilson, G. L., Miller, B., Berelowitz, M., Vinik, A. I., Collier, E., and Cleland, C. F., Somatostatin-like material is native to flowering plants. Endocrinology 117 (1985) 2093–2097.

    Article  Google Scholar 

  24. LeRoith, D., Shiloach, J., Roth, J., and Lesniak, M.A., Evolutionary origins of vertebrate hormones: Substances similar to mammalian insulins are native to unicellular organisms. Proc. natn. Acad. Sci. USA 77 (1980) 6184–6188.

    Article  Google Scholar 

  25. LeRoith, D., Shiloach, J., Roth, J., and Lesniak, M. A., Insulin or a closely related molecule is native to Escherichia coli. J. biol. Chem. 256 (1981) 6533–6536.

    Google Scholar 

  26. Loose, D.S., and Feldman, D., Characterization of a unique corticosterone-binding protein in Candida albicans. J. biol. Chem. 257 (1982) 4925–930.

    Google Scholar 

  27. Loose, D.S., Stover, E.P., Restrepo, A., Stevens, D.A., and Feldman, D., Estradiol binds to a receptor-like cytosol binding protein and initiates a biological response in Paracoccidioides brasiliensis. Proc. natn. Acad. Sci. USA 80: (1983) 7659–7663.

    Article  Google Scholar 

  28. Loumaye, E., Thorner, J., and Catt, K. J., Yeast mating pheromone activates mammalian gonadotrophs: Evolutionary conservation of a reproductive hormone. Science 218 (1982) 1324–1325.

    Article  Google Scholar 

  29. Macchia, V., Bates, R.W., and Pastan, I., Purification and properties of thyroid stimulating factor isolated from Clostridium perfringens. J. biol. Chem. 242 (1967) 3726–3730.

    Google Scholar 

  30. Maruo, T., Cohen, H., Segal, S. J., and Koide, S. S., Production of choriogonadotropin-like factor by a microorganism. Proc. natn. Acad. Sci. USA 76 (1979) 6622–6626.

    Article  Google Scholar 

  31. Morley, J.E., Meyer, N., Pekary, A.E., Melmed, S., Carso, H.E., Briggs, J.E., and Hershman, J.M., A prolactin inhibitory factor with immunocharacteristics similar to thyrotropin releasing factor (TRH) is present in rat pituitary tumors (GH3andW5) testicular tissue and a plant material, Alfalfa. Bioch. biophys Res. Comm. 96 (1980) 47–53.

    Article  Google Scholar 

  32. O’Day, D. H., Modes of cellular communication and sexual interactions in eukaryotic microbes, in: Sexual Interactions in Eukaryotic Microbes, pp.3–17. Eds D.H. O’Day and P.A. Horgen. Academic Press, New York 1981.

    Google Scholar 

  33. Perez-Cano, R., Murphy, P.K., Girgis, S.I., Arnett, T.R., Blankharn, I., and Maclntyre, I., Unicellular organisms contain a molecule resembling human calcitonin. Endocrinology 110 (1982) 673 (Abstract).

    Google Scholar 

  34. Petruzzelli, L., Herrera, R., Garcia, R., and Rosen, O. M., The insulin receptor of Drosophila melanogaster. Cold Spr. Harb. Symp. 3 (1985) 115–121.

    Google Scholar 

  35. Plisetskaya, E., Kazakov, V. K., Solititskaya, L., and Leibson, L. G., Insulin producing cells in the gut of freshwater bivalve molluscs Anodonta cygnea and Unio pictorum and the role of insulin in the regulation of their carbohydrate metabolism. Gen. comp. Endoer. 35 (1978) 133–145.

    Google Scholar 

  36. Powers, S., Katauka, T., Fasano, I., Goldfarb, M., Strathern, J., Broach, J., and Wigler, M., Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell 36 (1984) 607–612.

    Article  Google Scholar 

  37. Richert, N. D., and Ryan, R. J., Specific gonadotropin binding to Pseudomonas maltophilia Proc. natn. Acad. Sci. USA 73 (1977) 878–882.

    Article  Google Scholar 

  38. Riehl, R.M., and Toft, D.O., Analysis of the steroid receptor of Achlya ambisexualis. J. biol. Chem. 259 (1984) 15324–15330.

    Google Scholar 

  39. Riehl, R.M., Toft, D.O., Meyer, M.D., Carlson, G.L., and McMorris, T.C., Detection of a Pheromone-binding protein in the aquatic fungus Achlya ambisexualis. Expl Cell Res. 153 (1984) 544–549.

    Article  Google Scholar 

  40. Roth, J., LeRoith, D., Shiloach, J. Rosenzweig, H. L., Lesniak, M. A., and Havrankova, J., The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers. New Engl. J. Med. 306 (1982) 523–527.

    Article  Google Scholar 

  41. Roth, J., LeRoith, D., Shiloach, J., and Rubinovitz, C., Intercellular communication: An attempt at a unifying hypothesis. Clin. Res. 31 (1983) 354–363.

    Google Scholar 

  42. Roth, J., LeRoith, D., Shiloach, J., and Rubinovitz, C., Intercellular communication: An attempt at a unifying hypothesis. Clin. Res. 31 (1983) 354–363.

    Google Scholar 

  43. Schwabe, C., LeRoith, D., Thompson, R.P., Shiloach, J., and Roth, J., Relaxin extracted from protozoa (Tetrahymena pyriformis). J. biol. Chem. 258 (1983) 2778–2782.

    Google Scholar 

  44. Sela, I., Plant-virus interaction related to resistance and localisation of viral infections. Adv. Virus Res. 26 (1981) 201–237.

    Article  Google Scholar 

  45. Stefansson, K., Dieperink, M.E., Richman, D.P., Gomez, C.M., and Marton, L.S., Sharing of antigenic determinants between the nicotinic acetylcholine receptor and proteins in Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae: Possible role in the pathogenesis of Myasthenia gravis. New Engl. J. Med. 312 (1985) 221–225.

    Google Scholar 

  46. Stotzler, D., and Duntze, W., Isolation and characterization of four related peptides exhibiting a factor activity from Saccharomyces cerevisiae. Eur. J. Biochem. 65 (1976) 257–262.

    Article  Google Scholar 

  47. Temeles, G., Gibbs, J., D’Alonzo, J.S., Sigal, J.S., and Scolnick, E., Yeast and mammalian ras proteins have conserved biochemical propterties. Nature 313 (1985) 700–703.

    Article  Google Scholar 

  48. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., and Wigler, M., In yeast, RAS proteins are controlling elements of the cyclic AMP effector pathway. Cell 40 (1985) 27–36.

    Article  Google Scholar 

  49. Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L. M., Dull, T. J., Gray, A., Coussens, L., Liao, Y.-C., Tsubokawa, M., Mason, A., Seeberg, P.H., Grunfeld, C., Rosen, O.M., and Ramachandran, J., Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313 (1985) 756–761.

    Article  Google Scholar 

  50. Ullrich, A., Coussens, L., Hayflick, J. A., Dull, T.J., Gray, A., Tarn, A. W., Lee, J., Yarden, Y., Liberman, T.A., Schlessiner, J., Downward, J., Mayes, E.L.V., Whittle, N., Waterfield, M.D., and Seeburg, P.H., Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309 (1984) 418–425.

    Article  Google Scholar 

  51. Weiss, M., Ingbar, S.H., Winblad, S., and Kasper, D. L., Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science 219 (1983) 1331–1333.

    Article  Google Scholar 

  52. Weiss, M., Ingbar, S.H., Winblad, S., and Kasper, D. L., Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica. Science 219 (1983) 1331–1333.

    Article  Google Scholar 

  53. Zioudrov, C., Streaty, R. A., and Klee, W. A., Opioid peptides derived from food proteins: The exorphins. J. biol. Chem. 254 (1979) 2446–2450.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diabetes Branch, National Institute of Diabetes, and Digestive and Kidney Diseases, Bldg 10, Rm 8S-243, 9000 Rockville Pike, Bethesda, Maryland, 20892, USA

    D. LeRoith, C. Roberts Jr, M. A. Lesniak & J. Roth

Authors
  1. D. LeRoith
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Roberts Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Lesniak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Roth
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Semmelweis University of Medicine, Budapest, Hungary

    György Csaba

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Birkhäuser Verlag

About this chapter

Cite this chapter

LeRoith, D., Roberts, C., Lesniak, M.A., Roth, J. (1987). Receptors for intercellular messenger molecules in microbes: Similarities to vertebrate receptors and possible implications for diseases in man. In: Csaba, G. (eds) Development of Hormone Receptors. EXS 53: Experientia Supplementum, vol 53. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9291-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-9291-9_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9982-6

  • Online ISBN: 978-3-0348-9291-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation