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Ribonucleotide reductase inhibitors as anticancer and antiviral agents

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Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques

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Abstract

In all procaryotic and eucaryotic cells the synthesis of DNA requires a continuous supply of doexyribonucleoside triphosphates (dNTPs). The formation of dNTPs can be either through the ‘de novo’ pathway utilizing ribonucleotides as precursors, or using preformed deoxyribonucleotides via the ‘salvage’ pathway [1,2] (see fig. 1). However, due to the limited pool size of the deoxyribonucleotides in mammalian cells, rapid synthesis is necessary for proper cell replication. In the early 1950’s, in vivo experiments with C14-labelled nucleosides in rats revealed that deoxyribonucleotides were formed by a direct reduction of ribonucleotides [3]. De novo synthesis of dNTPs requires the action of the redox enzyme ribonucleotides reductase (RR) (EC 1.17.4.1).

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  1. Section of Biomedicinal Chemistry, School of Pharmacy, University of Southern California, Los Angeles, Calif., 90033, USA

    Eric J. Lien

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  1. Basel, Switzerland

    Ernst Jucker  & Urs Meyer  & 

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Lien, E.J. (1987). Ribonucleotide reductase inhibitors as anticancer and antiviral agents. In: Jucker, E., Meyer, U. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques, vol 31. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9289-6_2

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  • DOI: https://doi.org/10.1007/978-3-0348-9289-6_2

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