Skip to main content
SpringerLink
Log in

Adrenergic receptor research: Recent developments

  • Chapter
Book cover Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 33))

  • 139 Accesses

Abstract

Adrenaline was discovered in 1895 as a component of adrenal medullary extracts possessing a vasopressor effect [1]. Soon after its discovery, it was recognized that adrenaline can produce a variety of biological effects, both stimulatory and inhibitory [2]. The discovery in 1906 by Dale of the selective antagonism of pressor responses to adrenaline by ergot alkaloids [3] led to the concept of dual, stimulatory and inhibitory, catecholamine receptors. This concept was further developed by Ahlquist [4] who was the first to classify adrenergic receptors based on pharmacological specificity rather than response type. Ahlquist’s classification of α- and β-adrenergic receptors has stood the test of time and has proved to be a remarkably fertile concept. From a practical point of view, it has laid the ground for the development of new classes of therapeutic agents: the use of β-adrenergic antagonists in hypertension, coronary disease, and many other disorders makes these compounds the most widely used therapeutic agents, as recognized by the Nobel prize awarded to Sir James Black, the discoverer of propranolol [5]. Interestingly, the discovery of β-blocking agents was also the trigger for major theoretical advances, as it rekindled interest in Ahlquist’s dormant concept.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Oliver and E. A. Schafer: J. Physiol. (London) 18, 230 (1895).

    Google Scholar 

  2. T. R. Elliott: J. Physiol. (London) 32, 401 (1905).

    Google Scholar 

  3. H. H. Dale: J. Physiol. (London) 34, 163 (1906).

    Google Scholar 

  4. R. P. Ahlquist: Am. J. Physiol. 153, 586 (1948).

    Google Scholar 

  5. J. W. Black, A. F. Crowther, R. G. Shanks, L. H. Smith and A. G. Dornhorst: Lancet I, 1080 (1964).

    Article  Google Scholar 

  6. A. M. Lands, A. Arnold, J. P. McAuliff, F. P. Luduena and T. G. Brown: Nature 214, 597 (1967).

    Article  Google Scholar 

  7. S. R. O’Donnell and J. C. Wanstall: Br. J. Pharmac. 88, 41 (1986).

    Google Scholar 

  8. M. T. Nakada, J. M. Stadel, K. S. Poksay and S. T. Crooke: J. Pharmac. exp. Ther. 31, 377 (1987).

    Google Scholar 

  9. R. A. F. Dixon, B. K. Kobilka, D. J. Strader, J. L. Benovic, H. G. Dohlman, T. Frielle, M. A. Bolanowski, C. D. Bennett, E. Rands, R. E. Diehl, R. A. Mumford, E. E. Slater, E. S. Sigal, M. G. Caron, R. J. Lefkowitz and D. Strader: Nature 321, 75 (1986).

    Article  Google Scholar 

  10. T. Frielle, S. Collins, K. W. Daniel, M. G. Caron, R. J. Lefkowitz and K. Kobilka: Proc. natl Acad. Sci. USA 84, 7920 (1988).

    Article  Google Scholar 

  11. K. P. Minneman, G. A. Weiland and P. B. Molinoff: Molec. Pharmac. 17, 1 (1980).

    Google Scholar 

  12. Y. Yarden, H. Rodriguez, S. K.-F. Wong, D. R. Brandt, D. C. May, J. Burnier, R. N. Harkins, E. Y. Chen, J. Ramachandran, A. Ullrich and E. M. Ross: Proc. nat. Acad. Sci. USA 84, 46 (1986).

    Google Scholar 

  13. B. K. Kobilka, R. A. F. Dixon, T. Frielle, H. G. Dohlman, M. A. Bolanowski, I. S. Sigal, T. L. Yang-Feng, U. Francke, M. G. Caron and R. J. Lefkowitz: Proc. natl Acad. Sci. USA 84, 46 (1987).

    Article  Google Scholar 

  14. Z. Chung, C.-D. Wang, P. C. Potter, J. C. Venter and C. M. Fraser: J. biol. Chem. 263, 4052 (1988).

    Google Scholar 

  15. K. Kobilka, T. S. Kobilka, K. Daniel, J. W. Regan, M. G. Caron and R. J. Lefkowitz: Science 240, 1310 (1988).

    Article  Google Scholar 

  16. S. Z. Langer: Biochem. Pharmac. 23, 1793 (1974).

    Article  Google Scholar 

  17. S. Berthelsen and W. A. Pettinger: Life Sci. 21, 595 (1977).

    Article  Google Scholar 

  18. J. McGrath and V. Wilson: Trends pharmac. Sci. 9, 162 (1988).

    Article  Google Scholar 

  19. D B. Bylund: Trends pharmac. Sci 9, 356 (1988).

    Article  Google Scholar 

  20. C Han, P. W. Abel and K. P. Minneman: Nature 329, 333 (1987).

    Article  Google Scholar 

  21. R. M. Burch, A. Luini and J. Axelrod: Proc. natl Acad. Sci. USA 83, 7201 (1986).

    Article  Google Scholar 

  22. B. K. Kobilka, H. Matsui, T. S. Kobilka, T. L. Yang-Feng, U. Francke, M. G. Caron, R. J. Lefkowitz and J. W. Regan: Science 238, 650 (1987).

    Article  Google Scholar 

  23. J. W. Regan, T. S. Kobilka, T. L. Yang-Feng, M. G. Caron, R. J. Lefkowitz and B. K. Kobilka: Proc. natl Acad. Sci. USA 85, 6301 (1988).

    Article  Google Scholar 

  24. R. R. Ruffolo, A. C. Sulpizio, A. J. Nichols, R. M. DeMarinis and J. P. Hieble: Naunyn Schmiedeberg’s Arch. Pharmak. 336, 415 (1987).

    Article  Google Scholar 

  25. R.J. Shebuski, E. H. Ohlstein, J. M. Smith Jr. and R. R. Ruffolo Jr.: J. Pharmac. exp. Ther. 242, 158 (1987).

    Google Scholar 

  26. J. Kapocsi, G. T. Somogyi, N. Ludvig, P. Serfozo, L. G. Harsing Jr., R. J. Woods and E. S. Vizi: Neurochem. Res. 12, 141 (1987).

    Article  Google Scholar 

  27. G. Maura, A. Geminiani and M. Raiteri: Eur. J. Pharmacol. 116, 335 (1985).

    Article  Google Scholar 

  28. A. G. Gilman: Cell 36, 577 (1984).

    Article  Google Scholar 

  29. J. H. Exton: Am. J. Physiol. 248, E633 (1985).

    Google Scholar 

  30. M. J. Berridge and R. Irvine: Nature 312, 315 (1984).

    Article  Google Scholar 

  31. A. Ashkenazi, J. W. Winslow, E. G. Peralta, G. L. Peterson, M. I. Schimerlik, D. J. Capon and J. Ramachandran: Science 238, 672 (1987).

    Article  Google Scholar 

  32. M. E. Maguire and J. J. Erdos: J. biol. Chem. 255, 1030 (1980).

    Google Scholar 

  33. H. S. Banga, E. R. Simons, L. F. Brass and S. E. Rittenhouse: Proc. natl Acad. Sci. USA 83, 9197 (1986).

    Article  Google Scholar 

  34. L. L. Isom, E. J. Cragoe Jr. and L. E. Limbird: J. biol. Chem. 262, 17504(1987).

    Google Scholar 

  35. L. L. Isom, E. J. Cragoe Jr. and L. E. Limbird: J. biol. Chem. 263, 16513(1988).

    Google Scholar 

  36. Y. Nishizuka: Nature 334, 661 (1988).

    Article  Google Scholar 

  37. J. Axelrod, R. M. Burch and C. L. Jelsema: Trends Neurosci. 11, 117 (1988).

    Article  Google Scholar 

  38. R. J. Lefkowitz and M. G. Caron: J. biol. Chem. 263, 4993 (1988).

    Google Scholar 

  39. C. D. Strader, I. S. Sigal, R. B. Register, M. R. Candelore, E. Rands and R. A. F. Dixon: Proc. natl Acad. Sci. USA 84, 4384 (1987).

    Article  Google Scholar 

  40. H. G. Dohlman, M. Bouvier, J. L. Benovic, M. G. Caron and R. J. Lefkowitz: J. biol. Chem. 262, 14282 (1987).

    Google Scholar 

  41. S. K. F. Wong, C. Slaughter, A. E. Ruoho and E. M. Ross: J. biol. Chem. 263, 7925 (1988).

    Google Scholar 

  42. C. M. Fraser, F.-Z. Chung, C.-D. Wang and J. C. Venter: Proc. natl Acad. Sci. USA 85, 5478 (1988).

    Article  Google Scholar 

  43. D. R. Sibley and R. J. Lefkowitz: Nature 317, 124 (1985).

    Article  Google Scholar 

  44. G. Kunos: A. Rev. Physiol. Pharmac. 18, 291 (1978).

    Google Scholar 

  45. G. Kunos and E. J. N. Ishac: Biochem. Pharmac. 36, 1085 (1987).

    Article  Google Scholar 

  46. G. Kunos and M. Szentivanyi: Nature 217, 1077 (1968).

    Article  Google Scholar 

  47. G. Kunos: Trends pharmac. Sci. 5, 380 (1984).

    Article  Google Scholar 

  48. F. Okajima and M. Ui: Archs biochem. Biophys. 213, 658 (1982).

    Article  Google Scholar 

  49. G. Kunos, F. Hirata, E.J. N. Ishac and L. Tchakarov: Proc. natl Acad. Sci. USA 81, 6178 (1984).

    Article  Google Scholar 

  50. E. J. N. Ishac and G. Kunos: Proc. natl Acad. Sci. USA 83, 53 (1986).

    Article  Google Scholar 

  51. A. Tsujimoto, G. Tsujimoto, S. Azhar and B. B. Hoffman: Biochem. Pharmac. 35, 1400 (1986).

    Article  Google Scholar 

  52. T. Nakamura, A. Tomomura, C. Noda, M. Shimoji and A. Ichihara: J. biol. Chem. 258, 9283 (1983).

    Google Scholar 

  53. M. Refsnes, D. Sandnes, O. Melien, T. E. Sand, S. Jacobsen and T. Christoffersen: FEBS Lett. 164, 291 (1983).

    Article  Google Scholar 

  54. K. R. Schwarz, S. M. Lanier, E. A. Carter, C. J. Homey and R. M. Graham: Molec. Pharmac. 27, 200 (1985).

    Google Scholar 

  55. T. Nakamura, A. Tomomura, S. Kato, C. Noda and A. Ichihara: J. Biochem. 96, 127 (1984).

    Google Scholar 

  56. M. Refsnes, D. Sandnes and T. Christoffersen: Eur. J. Biochem. 163, 457(1987).

    Article  Google Scholar 

  57. H. Itoh, F. Okajima and M. Ui: J. biol. Chem. 259, 15464 (1984).

    Google Scholar 

  58. C. J. Lynch, V. Prpic, P. F. Blackmore and J. H. Exton: Molec. Pharmac. 29. 196 (1986).

    Google Scholar 

  59. R. J. Uhing, V. Prpic, H. Jiang and J. H. Exton: J. biol. Chem. 261, 2140 (1986).

    Google Scholar 

  60. T. M. Chan, P. F. Blackmore, K. E. Steiner and J. H. Exton: J. biol. Chem. 254, 2428 (1978).

    Google Scholar 

  61. R.J. Flower, J. N. Wood and L. Parente: Adv. Inflammation Res. 7, 61 (1984).

    Google Scholar 

  62. J. Vanecek, D. Sugden, J. L. Weller and D. C. Klein: J. Neurochem. 47, 678 (1986).

    Article  Google Scholar 

  63. F. Hirata: J. biol. Chem. 256, 7730 (1984).

    Google Scholar 

  64. M. Boyle, G. Yamamoto, M. Chen, J. Rivier and W. Vale: Proc. natl Acad. Sci. USA 85, 5556 (1988).

    Article  Google Scholar 

  65. L. Stern and G. Kunos: J. biol. Chem. 263, 15876 (1988).

    Google Scholar 

  66. T. Akahoshi, J. J. Oppenheim and K. Matsushima: J. exp. Med. 167, 924(1988).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 20892, Bethesda, MD, USA

    George Kunos

Authors
  1. George Kunos
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Basel, Switzerland

    Ernst Jucker

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Birkhäuser Verlag Basel

About this chapter

Cite this chapter

Kunos, G. (1989). Adrenergic receptor research: Recent developments. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 33. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9146-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-0348-9146-2_7

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9925-3

  • Online ISBN: 978-3-0348-9146-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation