Summary
Two classical and two nonclassical muscarinic agents were tested for their effects on neostriatal acetylcholine (ACh) release. The classical muscarinic antagonist, atropine (0.1-2 µM), increased ACh release in a dose-dependent fashion, whereas the ‘nonclassical’ antagonist, pirenzepine (2-200 µM), had no effect on ACh release. The muscarinic agonist, oxotremorine (1-100 µM), and its analog, oxotremorine-M (0.1–50 µM), both decreased ACh release in a dose-dependent fashion. The inhibitory potency of oxotremorine-M was approximately 20 times that of oxotremorine, and the inhibitory effects of both agonists were blocked by atropine. The results obtained with the muscarinic antagonists indicate that ‘M-2 type’ muscarinic receptors mediate ACh release in the neostriatum, but further pharmacological analyses are required to assign with certainty the receptor subtype involved in neostriatal ACh release.
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Weiler, M.H. (1989). Characterization of muscarinic receptors modulating acetylcholine release in the rat neostriatum. In: Frotscher, M., Misgeld, U. (eds) Central Cholinergic Synaptic Transmission. Experientia Supplementum, vol 57. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9138-7_21
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DOI: https://doi.org/10.1007/978-3-0348-9138-7_21
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