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Regulatory peptides in the respiratory system

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Regulatory Peptides

Part of the book series: Experientia Supplementum ((EXS,volume 56))

Summary

Many regulatory peptides have been described in the respiratory tract of animals and humans. Some peptides (bombesin, calcitonin, calcitonin gene-related peptide) are localised to neuroendocrine cells and may have a trophic or transmitter rôle. Others are localised to motor nerves. Vasoactive intestinal peptide and peptide histidine isoleucine are candidates for neurotransmitters of non-adrenergic inhibitory fibres and may be co-transmitters in cholinergic nerves. These peptides may regulate airway smooth muscle tone, bronchial blood flow and airway secretions. Sensory neuropeptides (substance P, neurokinin A and B, calcitonin gene-related peptide) may contract airway smooth muscle, stimulate mucus secretion and regulate bronchial blood flow and microvascular permeability. If released by an axon reflex mechanism these peptides may be involved in the pathogenesis of asthma. Other peptides, such as galanin and neuropeptide Y, are also present but their function is not yet known.

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  1. Royal Postgraduate Medical School Department of Histochemistry, Hammersmith Hospital, Du Cane Road, London, W12 0HS, England

    Julia M. Polak

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Barnes, P.J. (1989). Regulatory peptides in the respiratory system. In: Polak, J.M. (eds) Regulatory Peptides. Experientia Supplementum, vol 56. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9136-3_17

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  • DOI: https://doi.org/10.1007/978-3-0348-9136-3_17

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