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Regulatory Peptides pp 292–316Cite as

Peptides in the mammalian cardiovascular system

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Part of the book series: Experientia Supplementum ((EXS,volume 56))

Summary

Ample immunocytochemical evidence is now available demonstrating that several peptides are present in the mammalian cardiovascular system where they are localised to nerve fibres and myocardial cells. The neuropeptides (neuropeptide Y, calcitonin gene-related peptide, tachykinins and vasoactive intestinal polypeptide) are localised to large secretory vesicles in subpopulations of afferent or efferent nerves supplying the heart and vasculature of several mammals, including man. Although they often exert potent pharmacological effect on the tissues in which they occur their physiological significance has still to be established. They may act directly via specific receptors and/or indirectly by influencing the release and action of other cardiovascular transmitters. In marked contrast, atrial natriuretic peptide is produced by cardiac myocytes and considered to act as a circulating hormone.

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Authors
  1. J. Wharton
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  2. S. Gulbenkian
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Editors and Affiliations

  1. Royal Postgraduate Medical School Department of Histochemistry, Hammersmith Hospital, Du Cane Road, London, W12 0HS, England

    Julia M. Polak

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© 1989 Birkhäuser Verlag

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Wharton, J., Gulbenkian, S. (1989). Peptides in the mammalian cardiovascular system. In: Polak, J.M. (eds) Regulatory Peptides. Experientia Supplementum, vol 56. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9136-3_16

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  • DOI: https://doi.org/10.1007/978-3-0348-9136-3_16

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-1976-2

  • Online ISBN: 978-3-0348-9136-3

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