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Endocrine cells producing regulatory peptides

  • Chapter
Regulatory Peptides

Part of the book series: Experientia Supplementum ((EXS,volume 56))

Summary

Recent data on the immunolocalisation of regulatory peptides and related propeptide sequences in endocrine cells and tumours of the gastrointestinal tract, pancreas, lung,thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptides are the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, α-MSH and CLIP (corticotropinlike intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut EC (enterochromaffin) cells; NPY (neuropeptide Y)in adrenalin-type adrenal medullary cells, etc. Both tissueappropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.

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  1. E. Solcia
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  2. L. Usellini
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  3. R. Buffa
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  4. G. Rindi
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  1. Royal Postgraduate Medical School Department of Histochemistry, Hammersmith Hospital, Du Cane Road, London, W12 0HS, England

    Julia M. Polak

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Solcia, E. et al. (1989). Endocrine cells producing regulatory peptides. In: Polak, J.M. (eds) Regulatory Peptides. Experientia Supplementum, vol 56. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9136-3_13

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