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DNA Methylation pp 469–486Cite as

DNA methylation and genomic imprinting in mammals

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Part of the book series: EXS ((EXS,volume 64))

Abstract

In mammalian sexual reproduction, each parent contributes a haploid set of chromosomes to the offspring. It is usually believed that these two haploid sets are on the whole equivalent in their function: reciprocal crosses show identical phenotypic effects at many genetic loci. Only two clear exceptions to this rule have been recognized: sex-linked inheritance and cytoplasmic inheritance (the latter is actually not linked to the nucleus). Therefore, it seems reasonable to assume that autosomal genes behave in the same manner no matter which parent they are contributed by. However, recent studies have revealed that parental origin does affect gene expression at certain autosomal loci. In other words, these autosomal regions somehow remember their parental origin and regulate gene activity according to that memory. These genes constitute the third category of exceptions to the principle of reciprocity.

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Authors and Affiliations

  1. Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, CB2 4AT, England

    Hiroyuki Sasaki, Nicholas D. Allen & M. Azim Surani

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  1. Hiroyuki Sasaki
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  2. Nicholas D. Allen
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  3. M. Azim Surani
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  1. Friedrich Miescher-Institut, P.O. Box 2543, CH-4002, Basel, Switzerland

    Jean-Pierre Jost

  2. IRBM, Via Pontina Km 30,600, I-00040, Pomenzia (Roma), Italy

    Hans-Peter Saluz

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Sasaki, H., Allen, N.D., Azim Surani, M. (1993). DNA methylation and genomic imprinting in mammals. In: Jost, JP., Saluz, HP. (eds) DNA Methylation. EXS, vol 64. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9118-9_21

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  • DOI: https://doi.org/10.1007/978-3-0348-9118-9_21

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  • Print ISBN: 978-3-0348-9915-4

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