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Lipid Peroxidation. An Overview

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Free Radicals: from Basic Science to Medicine

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Abstract

Some decades ago lipid peroxidation was only known in the chemistry of oil and fat rancidicity, and its interest was mainly confined to the field of food technology. The possible importance of lipid peroxidation in biology as a damaging process for cellular membranes was first suggested by the studies of Tappel (1962). However, at that time, any possible implication in biopathology appeared restricted to conditions of deficiencies of vitamin E or other antioxidants, which are mainly limited to animals maintained on particular diets. The knowledge that lipid peroxidation can be linked to the electron transport chain of drug metabolism (Hochstein and Ernster, 1963), the recognition that the metabolism of carbon tetrachloride yields aloalkane free radicals (see Slater, 1972, for a review), and the observation that CCl4 greatly stimulates the peroxidation of liver microsomal lipids (Comporti et al., 1965; Recknagel and Ghoshal, 1966), led to the assumption that lipid peroxidation could be a basic mechanism of toxicity for a wide variety of chemicals.

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Authors and Affiliations

  1. Istituto di Patologia Generale, Università di Siena, Siena, Italy

    M. Comporti

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  1. M. Comporti
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Editors and Affiliations

  1. Department of Experimental Medicine and Oncology, University of Torino, I-101 25, Torino, Italy

    G. Poli , E. Albano  & M. U. Dianzani ,  & 

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© 1993 Birkhäuser Verlag

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Comporti, M. (1993). Lipid Peroxidation. An Overview. In: Poli, G., Albano, E., Dianzani, M.U. (eds) Free Radicals: from Basic Science to Medicine. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9116-5_6

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  • DOI: https://doi.org/10.1007/978-3-0348-9116-5_6

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9914-7

  • Online ISBN: 978-3-0348-9116-5

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